Lee, Hyun-Su Kim, Eun-Nam Jeong, Gil-Saeng
Published in
Biomolecules
While liquiritigenin, isolated from Spatholobus suberectus Dunn, is known to possess anti-inflammatory activities, it still remains to be known whether liquiritigenin has a suppressive effect on T cell activation and T cell-mediated disease. Here, we used Jurkat T cells to explore an underlying mechanism of pre-treatment with liquiritigenin in acti...
Romanova, Elena A Sharapova, Tatiana N Telegin, Georgii B Minakov, Alexei N Chernov, Alexander S Ivanova, Olga K Bychkov, Maxim L Sashchenko, Lidia P Yashin, Denis V
Published in
Cells
Investigation of interactions between a pro-inflammatory cytokine tumor necrosis factor (TNFα) and its receptor is required for the development of new treatments for autoimmune diseases associated with the adverse effects of TNFα. Earlier, we demonstrated that the innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, T...
Giavitto, Jean-Louis
National audience
Castellan, Gwenaëlle Cousien, Anthony Tran, Viet Chi
The global sensitivity analysis is a set of methods aiming at quantifying the contribution of an uncertain input parameter of the model (or combination of parameters) on the variability of the response. We consider here the estimation of the Sobol indices of order 1 which are commonly-used indicators based on a decomposition of the output's varianc...
Gao, H Liu, R Sun, X
Published in
European review for medical and pharmacological sciences
Long noncoding RNAs (lncRNAs) have drawn increasing attention due to their critical roles in various diseases, including melanoma. In this study, we aimed to explore the potential roles and underlying mechanisms of Small nucleolar RNA host gene 17 (SNHG17) in the modulation of melanoma progression. The levels of SNHG17 in melanoma tissues and cells...
Lion, Alexis Vuillemin, Anne Thornton, Jane S Theisen, Daniel Stranges, Saverio Ward, Malcolm
Published in
Health promotion international
The health benefits of physical activity (PA) are acknowledged and promoted by the scientific community, especially within primary care. However, there is little evidence that such promotion is provided in any consistent or comprehensive format. Brief interventions (i.e. discussion, negotiation or encouragement) and exercise referral schemes (i.e. ...
LOUM, Mor Absa Poursat, Marie-Anne Sow, Abdourahmane Sall, Amadou Loucoubar, Cheikh Gassiat, Elisabeth
In tropical regions, populations continue to suffer morbidity and mortality from malaria and arboviral diseases. In Kedougou (Senegal), these illnesses are all endemic due to the climate and its geographical position. The co-circulation of malaria parasites and arboviruses can explain the observation of coinfected cases. Indeed there is strong rese...
Roux, Jonathan Grimaud, Olivier Leray, Emmanuelle
Published in
Statistical methods in medical research
The concept of care pathways is increasingly being used to enhance the quality of care and to optimize the use of resources for health care. We here propose an innovative method in epidemiology that is derived from social sciences: state sequence analysis (SSA). This method takes into account the chronology of care consumption and allows for identi...
Legoupil, Caroline Enderle, Isabelle Le Baccon, Flore-Anne Bendavid, Claude Peltier, Lucas Bauville, Estelle Leveque, Jean Lavoue, Vincent Le Lous, Maela
Published in
European journal of emergency medicine : official journal of the European Society for Emergency Medicine
To assess the diagnostic performance of the NG-Test human chorionic gonadotropin (hCG) WB, which is a new point-of-care (POC) hCG whole-blood test. This prospective study included women consulted in early pregnancy units for vaginal bleeding and/or pelvic pain with unknown pregnancy status after medical consultation including a pelvic ultrasound sc...
Leneuve-Dorilas, Malika Favre, Anne Carles, Gabriel Louis, Alphonse Nacher, Mathieu
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
French Guiana has the highest birth rate in South America. This French territory also has the highest premature birth rate and perinatal mortality rate of all French territories. The objective was to determine the premature birth rate and to identify the prevalence of risk factors of premature birth in French Guiana. A retrospective study of all bi...
