Dhiantravan, Nattakorn Emmett, Louise Joshua, Anthony M Pattison, David A Francis, Roslyn J Williams, Scott Sandhu, Shahneen Davis, Ian D Vela, Ian Neha, Nitika
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Published in
BJU international
To assess the activity and safety of sequential lutetium-177 (177 Lu)-PSMA-617 and docetaxel vs docetaxel on a background of androgen deprivation therapy (ADT) in men with de novo metastatic hormone-naïve prostate cancer (mHNPC). UpFrontPSMA (NCT04343885) is an open-label, randomized, multicentre, phase 2 trial, recruiting 140 patients at 12 Austra...
Lopez, J Francisco Campbell, Angus Omer, Altan Stroman, Luke Bondad, Jasper Austin, Tom Reeves, Thomas Phelan, Curtis Leiblich, Aaron Philippou, Yiannis
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Published in
BJU international
To assess the feasibility of local anaesthetic transperineal (LATP) technique using a single-freehand transperineal (TP) access device, and report initial prostate cancer (PCa) detection, infection rates, and tolerability. Observational study of a multicentre prospective cohort, including all consecutive cases. LATP was performed in three settings:...
Wessels, Frederik Schmitt, Max Krieghoff-Henning, Eva Jutzi, Tanja Worst, Thomas S Waldbillig, Frank Neuberger, Manuel Maron, Roman C Steeg, Matthias Gaiser, Timo
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Published in
BJU international
To develop a new digital biomarker based on the analysis of primary tumour tissue by a convolutional neural network (CNN) to predict lymph node metastasis (LNM) in a cohort matched for already established risk factors. Haematoxylin and eosin (H&E) stained primary tumour slides from 218 patients (102 N+; 116 N0), matched for Gleason score, tumour si...
Marshall, Catherine H Tunacao, Jessa Danda, Varun Tsai, Hua-Ling Barber, John Gawande, Rakhee Weiss, Clifford R Denmeade, Samuel R Joshu, Corinne
Published in
BJU international
To investigate whether bipolar androgen therapy (BAT), involving rapid cyclic administration of high-dose testosterone, as a novel treatment for metastatic castration-resistant prostate cancer (mCRPC) promotes improvements in body composition and associated improvements in lipid profiles and quality of life. Men from two completed trials with compu...
Goldberg, Hanan Glicksman, Rachel Woon, Dixon Hoffman, Ally Shaikh, Hina Chandrasekar, Thenappan Klaassen, Zachary Wallis, Christopher J D Ahmad, Ardalan E Sanmamed-Salgado, Noelia
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Published in
BJU international
To assess whether free PSA ratio (FPSAR) at biochemical recurrence (BCR) can predict metastasis, castrate-resistant prostate cancer (CRPC), and cancer-specific survival (CSS), following therapy for localised disease. A single-centre retrospective cohort study (NCT03927287) including a discovery cohort composed of patients with an FPSAR after radica...
Tandogdu, Zafer Collins, Justin Shaw, Greg Rohn, Jennifer Koves, Bela Sachdeva, Ashwin Ghazi, Ahmed Haese, Alexander Mottrie, Alex Kumar, Anup
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Published in
BJU international
Coronavirus disease-19 (COVID-19) pandemic caused delays in definitive treatment of patients with prostate cancer. Beyond the immediate delay a backlog for future patients is expected. The objective of this work is to develop guidance on criteria for prioritisation of surgery and reconfiguring management pathways for patients with non-metastatic pr...
Dinneen, Eoin Haider, Aiman Grierson, Jack Freeman, Alex Oxley, Jon Briggs, Tim Nathan, Senthil Williams, Norman R Brew-Graves, Chris Persad, Raj
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Published in
BJU international
To report on the methods, peri-operative outcomes and histopathological concordance between frozen and final section from the NeuroSAFE PROOF feasibility study (NCT03317990). Between May 2018 and March 2019, 49 patients at two UK centres underwent robot-assisted radical prostatectomy (RARP). Twenty-five patient were randomized to NeuroSAFE RARP (in...
Poulson, Michael R Helrich, Samuel A Kenzik, Kelly M Dechert, Tracey A Sachs, Teviah E Katz, Mark H
Published in
BJU international
To examine the effects of racial residential segregation and structural racism on the diagnosis, treatment, and outcomes of patients with prostate cancer. This retrospective cohort study examined men diagnosed with prostate cancer between 2005 and 2015. We collected data from Black and White men, aged ≥30 years, living within the 100 most populous ...
Montorsi, Francesco Gandaglia, Giorgio Fossati, Nicola Dehò, Federico Briganti, Alberto
Published in
BJU international
Nair, Shiva M Hatiboglu, Gencay Relle, James Hetou, Khalil Hafron, Jason Harle, Christopher Kassam, Zahra Staruch, Robert Burtnyk, Mathieu Bonekamp, David
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Published in
BJU international
To report the 3-year follow-up of a Phase I study of magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) in 30 men with localised prostate cancer. Favourable 12-month safety and ablation precision were previously described. As a mandated safety criterion, TULSA was delivered as near whole-gland ablation, applying 3-mm ...
