Grinda, Thomas Joyon, Natacha Lusque, Amélie Lefèvre, Sarah Arnould, Laurent Penault-Llorca, Frédérique Macgrogan, Gaëtan Treilleux, Isabelle Vincent-Salomon, Anne Haudebourg, Juliette
...
Published in
npj Breast Cancer
Expression of hormone receptor (HR) for estrogens (ER) and progesterone (PR) and HER2 remains the cornerstone to define the therapeutic strategy for breast cancer patients. We aimed to compare phenotypic profiles between matched primary and metastatic breast cancer (MBC) in the ESME database, a National real-life multicenter cohort of MBC patients....
Goodwin, Pamela J. Dowling, Ryan J. O. Ennis, Marguerite Chen, Bingshu E. Parulekar, Wendy R. Shepherd, Lois E. Burnell, Margot J. Vander Meer, Rachel Molckovsky, Andrea Gurjal, Anagha
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Published in
npj Breast Cancer
Metformin may exert anticancer effects through indirect (mediated by metabolic changes) or direct mechanisms. The goal was to examine metformin impact on metabolic factors in non-diabetic subjects and determine whether this impact varies by baseline BMI, insulin, and rs11212617 SNP in CCTG MA.32, a double-blind placebo-controlled randomized adjuvan...
De Mattos-Arruda, Leticia Cortes, Javier Blanco-Heredia, Juan Tiezzi, Daniel G. Villacampa, Guillermo Gonçalves-Ribeiro, Samuel Paré, Laia Souza, Carla Anjos Ortega, Vanesa Sammut, Stephen-John
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Published in
npj Breast Cancer
The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore the genomic and microenvironment modulation of tumours exposed to therapy. Here, we characterised the mutational, gene expression, pathway enrichment and tumour-infiltrating lymphocytes (TILs) dynamics a...
Jørgensen, Mads G. Toyserkani, Navid M. Hansen, Frederik G. Bygum, Anette Sørensen, Jens A.
Published in
npj Breast Cancer
The impact of breast cancer-related lymphedema (BCRL) on long-term quality of life is unknown. The aim of this study was to investigate the impact of BCRL on health-related quality of life (HRQoL) up to 10 years after breast cancer treatment. This regional population-based study enrolled patients treated for breast cancer with axillary lymph node d...
Luo, Rui Chong, Weelic Wei, Qiang Zhang, Zhenchao Wang, Chun Ye, Zhong Abu-Khalaf, Maysa M. Silver, Daniel P. Stapp, Robert T. Jiang, Wei
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Published in
npj Breast Cancer
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. Although it is a rare subtype, IBC is responsible for roughly 10% of breast cancer deaths. In order to obtain a better understanding of the genomic landscape and intratumor heterogeneity (ITH) in IBC, we conducted whole-exome sequencing of 16 tissue samples (12 tumor and...
Wennstig, Anna-Karin Wadsten, Charlotta Garmo, Hans Johansson, Mikael Fredriksson, Irma Blomqvist, Carl Holmberg, Lars Nilsson, Greger Sund, Malin
Published in
npj Breast Cancer
Adjuvant radiotherapy (RT) for breast cancer (BC) has been associated with an increased risk of later radiation-induced lung cancer (LC). We examined the risk of primary LC in a population-based cohort of 52300 women treated for BC during 1992 to 2012, and 253796 age-matched women without BC. Cumulative incidence of LC was calculated by the Kaplan–...
Warner, Erica T. Rice, Megan S. Zeleznik, Oana A. Fowler, Erin E. Murthy, Divya Vachon, Celine M. Bertrand, Kimberly A. Rosner, Bernard A. Heine, John Tamimi, Rulla M.
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Published in
npj Breast Cancer
Percent mammographic density (PMD) is a strong breast cancer risk factor, however, other mammographic features, such as V, the standard deviation (SD) of pixel intensity, may be associated with risk. We assessed whether PMD, automated PMD (APD), and V, yielded independent associations with breast cancer risk. We included 1900 breast cancer cases an...
Tu, Zhenbo Schmoellerl, Johannes Mariani, Odette Zheng, Yurong Hu, Yi Vincent-Salomon, Anne Karnoub, Antoine E.
Published in
npj Breast Cancer
The development of triple-negative breast cancer (TNBC) is critically regulated by certain tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs), which we and others have shown promote TNBC progression by activating pro-malignant signaling in neighboring cancer cells. Characterization of these cascades would better ou...
Bushnell, Grace G. Deshmukh, Abhijeet P. den Hollander, Petra Luo, Ming Soundararajan, Rama Jia, Dongya Levine, Herbert Mani, Sendurai A. Wicha, Max S.
Published in
npj Breast Cancer
Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in treatment over the past several decades have significantly improved the outlook for this disease, most women who are diagnosed with estrogen receptor positive disease remain at risk of metastatic relapse for the remainder of their life. The cellular source of late ...
Timbrell, Simon Aglan, Hosam Cramer, Angela Foden, Phil Weaver, David Pachter, Jonathan Kilgallon, Aoife Clarke, Robert B. Farnie, Gillian Bundred, Nigel J.
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Published in
npj Breast Cancer
Cancer stem-like cells (CSC) contribute to therapy resistance and recurrence. Focal adhesion kinase (FAK) has a role in CSC regulation. We determined the effect of FAK inhibition on breast CSC activity alone and in combination with adjuvant therapies. FAK inhibition reduced CSC activity and self-renewal across all molecular subtypes in primary huma...
