Hudeček, Jan Voorwerk, Leonie van Seijen, Maartje Nederlof, Iris de Maaker, Michiel van den Berg, Jose van de Vijver, Koen K. Sikorska, Karolina Adams, Sylvia Demaria, Sandra
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Published in
npj Breast Cancer
Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management frame...
Amgad, Mohamed Stovgaard, Elisabeth Specht Balslev, Eva Thagaard, Jeppe Chen, Weijie Dudgeon, Sarah Sharma, Ashish Kerner, Jennifer K. Denkert, Carsten Yuan, Yinyin
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Published in
npj Breast Cancer
Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variabili...
Kos, Zuzana Roblin, Elvire Kim, Rim S. Michiels, Stefan Gallas, Brandon D. Chen, Weijie van de Vijver, Koen K. Goel, Shom Adams, Sylvia Demaria, Sandra
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Published in
npj Breast Cancer
Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research comm...
Muranen, Taru A. Khan, Sofia Fagerholm, Rainer Aittomäki, Kristiina Cunningham, Julie M. Dennis, Joe Leslie, Goska McGuffog, Lesley Parsons, Michael T. Simard, Jacques
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Published in
npj Breast Cancer
Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology. We have studied survival associations of genetic variants in two etiologically unique groups of breast cancer patients, the carriers of germline pathogenic variants in BRCA1 or BRCA2 genes. We found that rs57025206 was...
He, Zhen-Yu Lian, Chen-Lu Wang, Jun Lei, Jian Hua, Li Zhou, Juan Wu, San-Gang
Published in
npj Breast Cancer
This study aimed to investigate the prognostic value of biological factors, including histological grade, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status in de novo stage IV breast cancer. Based on eligibility, patient data deposited between 2010 and 2014 were collected from the surveil...
Guerrero Llobet, Sergi van der Vegt, Bert Jongeneel, Evelien Bense, Rico D. Zwager, Mieke C. Schröder, Carolien P. Everts, Marieke Fehrmann, Rudolf S. N. de Bock, Geertruida H. van Vugt, Marcel A. T. M.
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Published in
npj Breast Cancer
Replication stress entails the improper progression of DNA replication. In cancer cells, including breast cancer cells, an important cause of replication stress is oncogene activation. Importantly, tumors with high levels of replication stress may have different clinical behavior, and high levels of replication stress appear to be a vulnerability o...
Bodelon, Clara Oh, Hannah Derkach, Andriy Sampson, Joshua N. Sprague, Brian L. Vacek, Pamela Weaver, Donald L. Fan, Shaoqi Palakal, Maya Papathomas, Daphne
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Published in
npj Breast Cancer
Terminal duct lobular units (TDLUs) are the predominant anatomical structures where breast cancers originate. Having lesser degrees of age-related TDLU involution, measured as higher TDLUs counts or more epithelial TDLU substructures (acini), is related to increased breast cancer risk among women with benign breast disease (BBD). We evaluated wheth...
Muscarella, Aaron M. Dai, Wei Mitchell, Patrick G. Zhang, Weijie Wang, Hai Jia, Luyu Stossi, Fabio Mancini, Michael A. Chiu, Wah Zhang, Xiang H.-F.
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Published in
npj Breast Cancer
Migration and invasion are key properties of metastatic cancer cells. These properties can be acquired through intrinsic reprogramming processes such as epithelial-mesenchymal transition. In this study, we discovered an alternative “migration-by-tethering” mechanism through which cancer cells gain the momentum to migrate by adhering to mesenchymal ...
Xie, Yanping Davis Lynn, Brittny C. Moir, Nicholas Cameron, David A. Figueroa, Jonine D. Sims, Andrew H.
Published in
npj Breast Cancer
Publicly available tumor gene expression datasets are widely reanalyzed, but it is unclear how representative they are of clinical populations. Estimations of molecular subtype classification and prognostic gene signatures were calculated for 16,130 patients from 70 breast cancer datasets. Collated patient demographics and clinical characteristics ...
Gadaleta, Emanuela Fourgoux, Pauline Pirró, Stefano Thorn, Graeme J. Nelan, Rachel Ironside, Alastair Rajeeve, Vinothini Cutillas, Pedro R. Lobley, Anna E. Wang, Jun
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Published in
npj Breast Cancer
Widespread mammographic screening programs and improved self-monitoring allow for breast cancer to be detected earlier than ever before. Breast-conserving surgery is a successful treatment for select women. However, up to 40% of women develop local recurrence after surgery despite apparently tumor-free margins. This suggests that morphologically no...
