Published in iScience
This work experimentally studies a silicon-cored tungsten nanowire selective metamaterial absorber to enhance solar-thermal energy harvesting. After conformally coating a thin tungsten layer about 40 nm thick, the metamaterial absorber exhibits almost the same total solar absorptance of 0.85 as the bare silicon nanowire stamp but with greatly reduc...
Published in iScience
Reports indicate an association between COVID-19 and anosmia, as well as the presence of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium may represent a target of the virus, we generated RNA-seq libraries from human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the...
Published in iScience
Severe trauma predisposes patients to multiple independent infection episodes (MIIEs), leading to augmented morbidity and mortality. We developed a method to identify increased MIIE risk before clinical signs appear, which is fundamentally different from existing approaches entailing infections' detection after their establishment. Applying machine...
Published in iScience
Transcriptional fidelity depends on accurate promoter selection and initiation from the correct sites. In yeast, H3K36me3-mediated recruitment of the Rpd3S HDAC complex to gene bodies suppresses spurious transcription initiation. Here we describe an equivalent pathway in metazoans. PWWP2A/B is an H3K36me3 reader that forms a stable complex with HDA...
Published in iScience
● A novel method of protein-proofed single-cell RNA (pscRNA) profiling was developed. ● A rank list of ten potential SARS-CoV-2 target cells were proposed. ● The intestinal enterocytes are less likely to be the primary SARS-CoV-2 targets.
Published in iScience
Human Metabolism; Microbiome
Published in iScience
• All milk from recovered donors contained significant SARS-CoV-2-specific IgA • Most IgA could bind the Receptor Binding Domain (important neutralization epitope) • Most Receptor Binding Domain-specific IgA was in secretory (s) form • sIgA is durable in the mucosa, and thus potentially as a respiratory therapeutic
Published in iScience
Control of temperature variation is of primordial importance in particular areas of biomedicine. In this context, medical treatments such as hyperthermia and cryotherapy, and also the development and use of hydrogel-based biomaterials, are of particular concern. To enable accurate temperature measurement without perturbing or even destroying the bi...
Published in iScience
The molecular mechanisms of cytokine storm in patients with severe COVID-19 infections are poorly understood. To uncover these events, we performed transcriptome analyses of lung biopsies from patients with COVID-19, revealing a gene enrichment pattern similar to that of PPARγ-knockout macrophages. Single-cell gene expression analysis of bronchoalv...
Published in iScience
The pathophysiology, immune reaction, and differential vulnerability of different population groups and viral host immune system evasion strategies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not yet well understood. Here, we reviewed the multitude of known strategies of coronaviruses and other viruses to usurp mit...
