Manning, Tyler S Naecker, Benjamin N McLean, Iona R Rokers, Bas Pillow, Jonathan W Cooper, Emily A
Published in
eNeuro
A central question in neuroscience is how sensory inputs are transformed into percepts. At this point, it is clear that this process is strongly influenced by prior knowledge of the sensory environment. Bayesian ideal observer models provide a key link between data and theory that can help researchers evaluate how prior knowledge is represented and...
Van Berkel, A A Koopmans, F Gonzalez-Lozano, M A Lammertse, H C A Feringa, F Bryois, J Sullivan, P F Smit, A B Toonen, R F Verhage, M
...
Published in
eNeuro
Absence of presynaptic protein MUNC18-1 (gene: Stxbp1) leads to neuronal cell death at an immature stage before synapse formation. Here, we performed transcriptomic and proteomic profiling of immature Stxbp1 knockout (KO) cells to discover which cellular processes depend on MUNC18-1. Hippocampi of Stxbp1 KO mice showed cell-type specific dysregulat...
Ossandón, José P Zerr, Paul Shareef, Idris Kekunnaya, Ramesh Röder, Brigitte
Published in
eNeuro
What we see is intimately linked to how we actively and systematically explore the world through eye movements. However, it is unknown to what degree visual experience during early development is necessary for such systematic visual exploration to emerge. The present study investigated visual exploration behavior in ten human participants whose sig...
Suryadi, Cheng, Ruey-Kuang Birkett, Elliot Jesuthasan, Suresh Chew, Lock Yue
Published in
eNeuro
The habenula is an evolutionarily conserved structure of the vertebrate brain that is essential for behavioural flexibility and mood control. It is spontaneously active and is able to access diverse states when the animal is exposed to sensory stimuli. Here we investigate the dynamics of habenula spontaneous activity, to gain insight into how sensi...
Gannon, Mary Wang, Bing Stringfellow, Sara Anne Quintin, Stephan Mendoza, Itzel Srikantha, Thanushri Roberts, A. Claire Saito, Takashi Saido, Takaomi C. Roberson, Erik D.
...
Published in
eNeuro
Alzheimer’s disease (AD) is characterized by progressive cognitive impairment associated with synaptic dysfunction and dendritic spine loss and the pathologic hallmarks of β-amyloid (Aβ) plaques and hyperphosphorylated tau tangles. 14-3-3 proteins are a highly conserved family of proteins whose functions include regulation of protein folding, neuro...
Godenzini, Luca Shai, Adam S. Palmer, Lucy M.
Published in
eNeuro
The dendrites of cortical pyramidal neurons receive synaptic inputs from different pathways that are organized according to their laminar target. This architectural scheme provides cortical neurons with a spatial mechanism to separate information, which may support neural flexibility required during learning. Here, we investigated layer-specific pl...
Acquafredda, Miriam Binda, Paola Lunghi, Claudia
Published in
eNeuro
We used pupillometry to evaluate the effects of attention cueing on perceptual bi-stability, as reported by adult human observers. Perceptual alternations and pupil diameter were measured during two forms of rivalry, generated by presenting a white and a black disk to the two eyes (binocular rivalry) or splitting the disks between eyes (interocular...
Echeverry, Fabio A Ijaz, Sundas Pereda, Alberto E
Published in
eNeuro
The Mauthner cells are a pair of large reticulospinal neurons that organize sensory-evoked tail flip responses in fishes. An identifiable group of auditory "mixed" (electrical and chemical) synaptic contacts known as "Large Myelinated Club endings" on these cells have provided a valuable model for the study of synaptic transmission in the vertebrat...
Holley, S. M. Oikonomou, K. D. Swift, C. M. Mohan, L. Matthews, B. Vega, O. Mkrtchyan, G. Cepeda, C. Levine, M. S.
Published in
eNeuro
As Huntington’s disease (HD) progresses, there is a significant loss of neurons in the striatum in addition to a distinct thinning of the cerebral cortex. Despite an early presence of sensorimotor deficits in patients with HD, electrophysiological studies designed to assess the integrity of thalamocortical circuits are sparse. Using the R6/2 mouse ...
Lopes, Marinho A Bhatia, Sanchita Brimble, Glen Zhang, Jiaxiang Hamandi, Khalid
Published in
eNeuro
People with photosensitive epilepsy (PSE) are prone to seizures elicited by visual stimuli. The possibility of inducing epileptiform activity in a reliable way makes PSE a useful model to understand epilepsy, with potential applications for the development of new diagnostic methods and new treatments for epilepsy. A relationship has been demonstrat...