Khalid, Kasifa Frei, Julia Aboouf, Mostafa A. Koester-Hegmann, Christina Gassmann, Max Fritschy, Jean-Marc Schneider Gasser, Edith M.
Published in
eNeuro
Several neurodevelopmental disabilities are strongly associated with alterations in GABAergic transmission, and therapies to stimulate its normal development are lacking. Erythropoietin (EPO) is clinically used in neonatology to mitigate acute brain injury, and to stimulate neuronal maturation. Yet it remains unclear whether EPO can stimulate matur...
Chang, Kun-Che Bian, Minjuan Xia, Xin Madaan, Ankush Sun, Catalina Wang, Qizhao Li, Liang Nahmou, Michael Noro, Takahiko Yokota, Satoshi
...
Published in
eNeuro
The failure of adult CNS neurons to survive and regenerate their axons after injury or in neurodegenerative disease remains a major target for basic and clinical neuroscience. Recent data demonstrated in the adult mouse that exogenous expression of Sry-related high-mobility-box 11 (Sox11) promotes optic nerve regeneration after optic nerve injury b...
Urai, Anne E. Aguillon-Rodriguez, Valeria Laranjeira, Inês C. Cazettes, Fanny Mainen, Zachary F. Churchland, Anne K.
Published in
eNeuro
Powerful neural measurement and perturbation tools have positioned mice as an ideal species for probing the neural circuit mechanisms of cognition. Crucial to this success is the ability to motivate animals to perform specific behaviors. One successful strategy is to restrict their water intake, rewarding them with water during a behavioral task. H...
Leyrer-Jackson, Jonna M. Holter, Michael Overby, Paula F. Newbern, Jason M. Scofield, Michael D. Olive, M. Foster Gipson, Cassandra D.
Published in
eNeuro
Nicotine, the primary addictive substance in tobacco, is widely abused. Relapse to cues associated with nicotine results in increased glutamate release within nucleus accumbens core (NAcore), modifying synaptic plasticity of medium spiny neurons (MSNs), which contributes to reinstatement of nicotine seeking. However, the role of cholinergic interne...
Alam, Mahabub Maraj Zhao, Xiao-Feng Liao, Yuan Mathur, Ramkumar McCallum, Sarah E. Mazurkiewicz, Joseph E. Adamo, Matthew A. Feustel, Paul Belin, Sophie Poitelon, Yannick
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Published in
eNeuro
Excessive activation of mTOR in microglia impairs CNS homeostasis and causes severe epilepsy. Autophagy constitutes an important part of mTOR signaling. The contribution of microglial autophagy to CNS homeostasis and epilepsy remains to be determined. Here, we report that ATG7KO mice deficient for autophagy in microglia display a marked increase of...
Manuel, Marin
Published in
eNeuro
Intracellular recordings using sharp microelectrodes often rely on a technique called discontinuous current-clamp (DCC) to accurately record the membrane potential while injecting current through the same microelectrode. It is well known that a poor choice of DCC switching rate can lead to underestimation or overestimation of the cell potential; ho...
Wu, Xingqi Wang, Lu Geng, Zhi Wei, Ling Yan, Yibing Xie, Chengjuan Chen, Xingui Ji, Gong-Jun Tian, Yanghua Wang, Kai
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Published in
eNeuro
Noninvasive brain stimulation to enhance cognition is an area of increasing research interest. Theta burst stimulation (TBS) is a novel accelerated form of stimulation, which more closely mimics the brain's natural firing patterns and may have greater effects on cognitive performance. We report here the comparative assessment of the effect of conve...
Zareian, Behzad Zhang, Zhaoran Zagha, Edward
Published in
eNeuro
Responding to a stimulus requires transforming an internal sensory representation into an internal motor representation. Where and how this sensory-motor transformation occurs is a matter of vigorous debate. Here, we trained male and female mice in a whisker detection go/no-go task in which they learned to respond (lick) following a transient whisk...
Ash, Ryan Thomas Park, Jiyoung Suter, Bernhard Zoghbi, Huda Yaya Smirnakis, Stelios Manolis
Published in
eNeuro
Autism-associated genetic mutations may perturb the balance between stability and plasticity of synaptic connections in the brain. Here we report an increase in the formation and stabilization of dendritic spines in the cerebral cortex of the mouse model of MECP2-duplication syndrome, a high-penetrance form of syndromic autism. Increased stabilizat...
Lee, Christopher M. Sadowski, Renee N. Schantz, Susan L. Llano, Daniel A.
Published in
eNeuro
Polychlorinated biphenyls (PCBs) are enduring environmental toxicants and exposure is associated with neurodevelopmental deficits. The auditory system appears particularly sensitive, as previous work has shown that developmental PCB exposure causes both hearing loss and gross disruptions in the organization of the rat auditory cortex. However, the ...