Neininger-Castro, Abigail C Hayes, James B Sanchez, Zachary C Taneja, Nilay Fenix, Aidan M Moparthi, Satish Vassilopoulos, Stéphane Burnette, Dylan Tyler
Published in
eLife
Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat. The alignment of the individual sarcomeres is important for proper force generation, and misaligned sarcomeres are associated with diseases, including cardiomyopathies an...
Kandola, Tej Venkatesan, Shriram Zhang, Jiahui Lerbakken, Brooklyn T Von Schulze, Alex Blanck, Jillian F Wu, Jianzheng Unruh, Jay R Berry, Paula Lange, Jeffrey J
...
Published in
eLife
Diseases that typically occur later in life, such as Alzheimer’s, are often caused by specific proteins clumping together into structures known as amyloids. Once the process starts, amyloids will continue to form, leading to worse symptoms that cannot be cured. The best way to treat these diseases is therefore to stop amyloids from arising in the f...
Boissonnet, Tom Tripodi, Matteo Asari, Hiroki
Published in
eLife
When light enters the eyes, it is focused onto the retina, a thin layer of brain tissue at the back of the eye. The retina converts light information into electrical signals that are transmitted to the rest of the brain to perceive vision. Unlike the rest of the brain, this light-processing tissue can continue working even when removed from an anim...
Verharen, Jeroen P H
Published in
eLife
Peer review is a vital step in ensuring the quality and accuracy of scientific research before publication. Experts assess research manuscripts, advise journal editors on publishing them, and provide authors with recommendations for improvement. But some scientists have raised concerns about potential biases and subjectivity in the peer review proc...
Marmor, Odeya Pollak, Yael Doron, Chen Helmchen, Fritjof Gilad, Ariel
Published in
eLife
We learn from our experience but the underlying neuronal mechanisms incorporating past information to facilitate learning is relatively unknown. Specifically, which cortical areas encode history-related information and how is this information modulated across learning? To study the relationship between history and learning, we continuously imaged c...
Koh, Jaemoon Woo, Yeon Duk Yoo, Hyun Jung Choi, Jun-Pyo Kim, Sae Hoon Chang, Yoon-Seok Jung, Kyeong Cheon Kim, Ji Hyung Jeon, Yoon Kyung Kim, Hye Young
...
Published in
eLife
Invariant natural-killer T (iNKT) cells play pathogenic roles in allergic asthma in murine models and possibly also humans. While many studies show that the development and functions of innate and adaptive immune cells depend on their metabolic state, the evidence for this in iNKT cells is very limited. It is also not clear whether such metabolic r...
Ruan, Xiaohao Huang, Da Zhan, Yongle Huang, Jingyi Huang, Jinlun Ng, Ada Tsui-Lin Tsu, James Hok-Leung Na, Rong
Published in
eLife
Better cancer treatment and early detection have increased survival rates among patients with cancer. But some cancer survivors can develop a second cancer called a second primary cancer. Second primary cancers may occur months or years after successful treatment of the primary cancer. They are not caused by the spread of the original tumor like a ...
Rich-Edwards, Janet W Maney, Donna L
Published in
eLife
To enhance inclusivity and rigor, many funding agencies and journals now mandate the inclusion of females as well as males in biomedical studies. These mandates have enhanced generalizability and created unprecedented opportunities to discover sex differences. However, education in sound methods to consider sex as a subgroup category has lagged beh...
Llaurens, Violaine
Published in
eLife
A genetic duplication event during evolution allowed male wood tiger moths to have either yellow or white patterns on their wings. © 2023, Llaurens.
Bouhamida, Esmaa Chaudhry, Hina W
Published in
eLife
It may be possible to treat cardiac hypertrophy and injury by using drugs that inhibit a protein called SIRT2. © 2023, Bouhamida and Chaudhry.
