Fang, Si Holmes, Michael V Gaunt, Tom R Davey Smith, George Richardson, Tom G
Published in
eLife
Polygenic scores (PGS) are becoming an increasingly popular approach to predict complex disease risk, although they also hold the potential to develop insight into the molecular profiles of patients with an elevated genetic predisposition to disease. We sought to construct an atlas of associations between 125 different PGS derived using results fro...
Kurvers, Ralf H J M Snijders, Lysanne
Published in
eLife
A large-scale experiment demonstrates sex differences in cooperation and competition that can explain group size variation in ostriches. © 2022, Kurvers and Snijders.
Vollmuth, Nadine Schlicker, Lisa Guo, Yongxia Hovhannisyan, Pargev Janaki-Raman, Sudha Kurmasheva, Naziia Schmitz, Werner Schulze, Almut Stelzner, Kathrin Rajeeve, Karthika
...
Published in
eLife
Chlamydia trachomatis (Ctr) can persist over extended times within their host cell and thereby establish chronic infections. One of the major inducers of chlamydial persistence is interferon-gamma (IFN-γ) released by immune cells as a mechanism of immune defence. IFN-γ activates the catabolic depletion of L-tryptophan (Trp) via indoleamine-2,3-diox...
Sefton, Elizabeth M Gallardo, Mirialys Tobin, Claire E Collins, Brittany C Colasanto, Mary P Merrell, Allyson J Kardon, Gabrielle
Published in
eLife
The diaphragm is a domed muscle between the thorax and abdomen essential for breathing in mammals. Diaphragm development requires the coordinated development of muscle, connective tissue, and nerve, which are derived from different embryonic sources. Defects in diaphragm development cause the common and often lethal birth defect, congenital diaphra...
Hayward, Laura Katharine Sella, Guy
Published in
eLife
Polygenic adaptation is thought to be ubiquitous, yet remains poorly understood. Here, we model this process analytically, in the plausible setting of a highly polygenic, quantitative trait that experiences a sudden shift in the fitness optimum. We show how the mean phenotype changes over time, depending on the effect sizes of loci that contribute ...
Cohen, Hadar Baram, Noam Fridman, Chaya Mushka Edry-Botzer, Liat Salomon, Dor Gerlic, Motti
Published in
eLife
The type VI secretion system (T6SS) is used by bacteria to deliver toxic effectors directly into target cells. Most T6SSs mediate antibacterial activities, whereas the potential anti-eukaryotic role of T6SS remains understudied. Here, we found a Vibrio T6SS that delivers two novel effectors into mammalian host immune cells. We showed that these eff...
Klingelhöfer-Jens, Maren Ehlers, Mana R Kuhn, Manuel Keyaniyan, Vincent Lonsdorf, Tina B
Published in
eLife
Here, we follow the call to target measurement reliability as a key prerequisite for individual-level predictions in translational neuroscience by investigating (1) longitudinal reliability at the individual and (2) group level, (3) internal consistency and (4) response predictability across experimental phases. One hundred and twenty individuals p...
Mikesell, Alexander R Isaeva, Olena Moehring, Francie Sadler, Katelyn E Menzel, Anthony D Stucky, Cheryl L
Published in
eLife
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte exp...
Truelove, Shaun Smith, Claire P Qin, Michelle Mullany, Luke C Borchering, Rebecca K Lessler, Justin Shea, Katriona Howerton, Emily Contamin, Lucie Levander, John
...
Published in
eLife
In Spring 2021, the highly transmissible SARS-CoV-2 Delta variant began to cause increases in cases, hospitalizations, and deaths in parts of the United States. At the time, with slowed vaccination uptake, this novel variant was expected to increase the risk of pandemic resurgence in the US in summer and fall 2021. As part of the COVID-19 Scenario ...
Walker, Tom WN Gavazov, Konstantin Guillaume, Thomas Lambert, Thibault Mariotte, Pierre Routh, Devin Signarbieux, Constant Block, Sebastián Münkemüller, Tamara Nomoto, Hanna
...
Published in
eLife
In a terrestrial ecosystem, the carbon cycle primarily represents the balance between plants consuming carbon dioxide from the atmosphere and soil microbes releasing carbon stored in the soil into the atmosphere (mostly as carbon dioxide). Given that carbon dioxide traps heat in the atmosphere, the balance of carbon inputs and outputs from an ecosy...
