Gil, José Rosin, Leah F Navarrete, Emily Chowdhury, Neil Abraham, Sameer Cornilleau, Gaétan Lei, Elissa P Mozziconacci, Julien Mirny, Leonid A Muller, Héloïse
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bioRxiv : the preprint server for biology
The hallmarks of chromosome organization in multicellular eukaryotes are chromosome territories (CT), chromatin compartments, and insulated domains, including topologically associated domains (TADs). Yet, most of these elements of chromosome organization are derived from analyses of a limited set of model organisms, while large eukaryotic groups, i...
DiPeso, Lucian Pendyala, Sriram Huang, Heather Z Fowler, Douglas M Hatch, Emily M
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bioRxiv : the preprint server for biology
Recent advances in isolating cells based on visual phenotypes have transformed our ability to identify the mechanisms and consequences of complex traits. Micronucleus (MN) formation is a frequent outcome of genome instability, triggers extensive disease-associated changes in genome structure and signaling coincident with MN rupture, and is almost e...
Chakraborty, Anirban Sreenivasmurthy, Sravan Gopalkrishnashet... Miller, Wyatt Huai, Weihan Biswas, Tapan Mandal, Santi Mohan Boscá, Lisardo Krishnan, Balaji Ghosh, Gourisankar Hazra, Tapas
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bioRxiv : the preprint server for biology
Huntington's disease (HD) and spinocerebellar ataxia type 3 (SCA3) are the two most prevalent polyglutamine (polyQ) neurodegenerative diseases, caused by CAG (encoding glutamine) repeat expansion in the coding region of the huntingtin (HTT) and ataxin-3 (ATXN3) proteins, respectively. We have earlier reported that the activity, but not the protein ...
Gatti, Priya Schiavon, Cara R Manor, Uri Germain, Marc Cicero, Julien
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bioRxiv : the preprint server for biology
Mitochondria play a crucial role in the regulation of cellular metabolism and signalling. Mitochondrial activity is modulated by the processes of mitochondrial fission and fusion, which are required to properly balance respiratory and metabolic functions, transfer material between mitochondria, and remove defective mitochondria. Mitochondrial fissi...
Tobin, Melanie Sheth, Janaki Neimark Wood, Katherine C Michel, Erin K Geffen, Maria Neimark
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bioRxiv : the preprint server for biology
Cortical circuits contain multiple types of inhibitory neurons which shape how information is processed within neuronal networks. Here, we asked whether somatostatin-expressing (SST) and vasoactive intestinal peptide-expressing (VIP) inhibitory neurons have distinct effects on population neuronal responses to noise bursts of varying intensities. We...
Rahmani, Shahrokh Jafree, Daniyal J Lee, Peter D Tafforeau, Paul Brunet, Joseph Nandawar, Sonal Jacob, Joseph Bellier, Alexandre Ackermann, Maximilian Jonigk, Danny D
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bioRxiv : the preprint server for biology
The architecture of the kidney vasculature is essential for its function. Although structural profiling of the intact rodent kidney vasculature has been performed, it is challenging to map vascular architecture of larger human organs. We hypothesised that hierarchical phase-contrast tomography (HiP-CT) would enable quantitative analysis of the enti...
Bomba-Warczak, Ewa K Velez, Karen M Zhou, Luhan T Guillermier, Christelle Edassery, Seby Steinhauser, Matthew L Savas, Jeffrey N Elizabeth Duncan, Francesca
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bioRxiv : the preprint server for biology
The mechanisms contributing to age-related deterioration of the female reproductive system are complex, but aberrant protein homeostasis is a major contributor. We elucidated the exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized str...
Giese, Arnaud P J Weng, Wei-Hsiang Kindt, Katie S Chang, Vanessa H H Montgomery, Jonathan S Ratzan, Evan M Beirl, Alisha J Aponte Rivera, Roberto Lotthammer, Jeffrey M Walujkar, Sanket
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bioRxiv : the preprint server for biology
Calcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like 1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical transduction (MET) apparatus. These interactions have been proposed to be functionally relevant across mechanosensory organs and vertebrate species. Here we show that both CIB2 an...
Reyes, Rochelle-Jan Pham, Olivia Fergusson, Ryan Ceberio, Niquo Clark, Candace Cohen, C Sarah Fuse, Megumi Pennings, Pleuni
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bioRxiv : the preprint server for biology
In 2020, many students lost summer opportunities due to the COVID-19 pandemic. We wanted to offer students an opportunity to learn computational skills and be part of a community while they were stuck at home. Because the pandemic was very isolating, it was important to support students to learn and build community online. We used lessons learned f...
Occean, James R Yang, Na Sun, Yan Dawkins, Marshall S Munk, Rachel Belair, Cedric Dar, Showkat Anerillas, Carlos Wang, Lin Shi, Changyou
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bioRxiv : the preprint server for biology
DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of DNA methylation, is typically enriched at enhancers and gene bodies of transcriptionally active and tissue-specific genes. Although aberrant genomic 5hmC has been implicated in age-related diseases, its functional role in aging remains unknown. Here, using mouse liver and cere...
