Feng, Xu-Dong Zhou, Jia-Hang Chen, Jun-Yao Feng, Bing Hu, Rui-Tian Wu, Jian Pan, Qiao-Ling Yang, Jin-Feng Yu, Jiong Cao, Hong-Cui
...
Published in
World Journal of Stem Cells
BACKGROUND The effect of hypoxia on mesenchymal stem cells (MSCs) is an emerging topic in MSC biology. Although long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) are reported to play a critical role in regulating the biological characteristics of MSCs, their specific expression and co-expression profiles in human placenta-derived MSCs (hP-M...
Shi, Meng-Yue Liu, Lian Yang, Fu-Yuan
Published in
World Journal of Stem Cells
Inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis and is an idiopathic, chronic inflammatory disease of the colonic mucosa. The occurrence of IBD, causes irreversible damage to the colon and increases the risk of carcinoma. The routine clinical treatment of IBD includes drug treatment, endoscopic treatment and surgery...
Tang, Li-Xia Wei, Bing Jiang, Lu-Yao Ying, You-You Li, Ke Chen, Tian-Xi Huang, Ruo-Fei Shi, Miao-Jun Xu, Hang
Published in
World Journal of Stem Cells
BACKGROUND Recent studies have demonstrated that mesenchymal stem cells (MSCs) can rescue injured target cells via mitochondrial transfer. However, it has not been fully understood how bone marrow-derived MSCs repair glomeruli in diabetic kidney disease (DKD). AIM To explore the mitochondrial transfer involved in the rescue of injured glomerular en...
Razzaq, Syeda Saima Khan, Irfan Naeem, Nadia Salim, Asmat Begum, Sumreen Haneef, Kanwal
Published in
World Journal of Stem Cells
BACKGROUND Heart diseases are the primary cause of death all over the world. Following myocardial infarction, billions of cells die, resulting in a huge loss of cardiac function. Stem cell-based therapies have appeared as a new area to support heart regeneration. The transcription factors GATA binding protein 4 (GATA-4) and myocyte enhancer factor ...
Wong, Chui-Wei Han, Hao-Wei Hsu, Shan-hui
Published in
World Journal of Stem Cells
BACKGROUND The therapeutic potential of mesenchymal stem cells (MSCs) in the form of three-dimensional spheroids has been extensively demonstrated. The underlying mechanisms for the altered cellular behavior of spheroids have also been investigated. Cell membrane fluidity is a critically important physical property for the regulation of cell behavi...
Garrigós, Murilo Montenegro de Oliveira, Fernando Anselmo Nucci, Mariana Penteado Nucci, Leopoldo Penteado Alves, Arielly da Hora Dias, Olivia Furiama Metropolo Gamarra, Lionel Fernel
Published in
World Journal of Stem Cells
BACKGROUND Bone marrow transplantation (BMT) can be applied to both hematopoietic and nonhematopoietic diseases; nonetheless, it still comes with a number of challenges and limitations that contribute to treatment failure. Bearing this in mind, a possible way to increase the success rate of BMT would be cotransplantation of mesenchymal stem cells (...
Sheykhhasan, Mohsen Poondla, Naresh
Published in
World Journal of Stem Cells
Early intervention with bone marrow mesenchymal stem cells to change the form and function of the gut microbiota may help rats regain neurological function after a stroke.
Padovano, Martina Scopetti, Matteo Manetti, Federico Morena, Donato Radaelli, Davide D’Errico, Stefano Di Fazio, Nicola Frati, Paola Fineschi, Vittorio
Published in
World Journal of Stem Cells
The latest achievements in the field of pancreas transplantation and stem cell therapy require an effort by the scientific community to clarify the ethical implications of pioneering treatments, often characterized by high complexity from a surgical point of view, due to transplantation of multiple organs at the same time or at different times, and...
Huang, Xiao-Yan Jin, Zhan-Kui Dou, Meng Zheng, Bing-Xuan Zhao, Xiang-Rong Feng, Qing Feng, Yang-Meng Duan, Xiang-Long Tian, Pu-Xun Xu, Cui-Xiang
...
Published in
World Journal of Stem Cells
BACKGROUND Immature dendritic cells (imDCs) play an important role in the induction of donor-specific transplant immunotolerance. However, these cells have limitations, such as rapid maturation and a short lifespan in vivo . In previous studies, induced pluripotent stem cells (iPSCs) differentiated into imDCs, and sinomenine (SN) was used to inhibi...
Qazi, Rida-e-Maria Khan, Irfan Haneef, Kanwal Malick, Tuba Shakil Naeem, Nadia Ahmad, Waqas Salim, Asmat Mohsin, Sadia
Published in
World Journal of Stem Cells
BACKGROUND Cardiovascular diseases are the major cause of mortality worldwide. Regeneration of the damaged myocardium remains a challenge due to mechanical constraints and limited healing ability of the adult heart tissue. Cardiac tissue engineering using biomaterial scaffolds combined with stem cells and bioactive molecules could be a highly promi...
