Cheng, Yu-Xi Peng, Dong Tao, Wei Zhang, Wei
Published in
World Journal of Gastrointestinal Oncology
This review summarizes the definition and surgical methods of oncometabolic surgery according to previous studies. Then, the authors discuss the beneficial effects observed after gastrectomy in gastric cancer (GC) patients with concurrent hypertension or type 2 diabetes mellitus (T2DM). The authors summarize the current studies analyzing the remiss...
Wu, Jing Xue, Ran Jiang, Rong-Tao Meng, Qing-Hua
Published in
World Journal of Gastrointestinal Oncology
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide, accounting for approximately 75%-85% of primary liver cancers. Metabolic alterations have been labeled as an emerging hallmark of tumors. Specially, the last decades have registered a significant improvement in our understanding of the role of metabolism in driving the c...
Wu, Pei Xu, Hui-Mian Zhu, Zhi
Published in
World Journal of Gastrointestinal Oncology
BACKGROUND Neoadjuvant chemoradiotherapy (Neo-CRT) is the current standard strategy for treating locally advanced rectal cancer. However, it delays the administration of optimal chemotherapy and increases toxicity. AIM To compare the feasibility and efficacy of neoadjuvant chemotherapy (Neo-CT) and Neo-CRT for patients with locally advanced rectal ...
Fujita, Motomichi Suzuki, Hideo Fukai, Fumio
Published in
World Journal of Gastrointestinal Oncology
Tenascin-C (TNC) is an adhesion modulatory protein present in the extracellular matrix that is highly expressed in several malignancies, including colon cancer. Although TNC is considered a negative prognostic factor for cancer patients, the substantial role of the TNC molecule in colorectal carcinogenesis and its malignant progression is poorly un...
Herold, Zoltan Szasz, A Marcell Dank, Magdolna
Published in
World Journal of Gastrointestinal Oncology
Hepatopancreatobiliary tumors are challenging to treat, and the advanced or metastatic forms have a very low 5-year survival rate. Several drug combinations have been tested, and new therapeutic approaches have been introduced in the last decades, including radiofrequency and heat based methods. Hyperthermia is the artificial heating of tumors by v...
Li, Zhi-Peng Liu, Ju-Xin Lu, Lin-Lin Wang, Li-Li Xu, Lin Guo, Zong-Hao Dong, Quan-Jiang
Published in
World Journal of Gastrointestinal Oncology
Dysbiosis of the gastric microbiome is involved in the development of gastric cancer (GC). A number of studies have demonstrated an increase in the relative abundance of Lactobacillus in GC. In this review, we present data that support the overgrowth of Lactobacillus in GC from studies on molecular and bacterial culture of the gastric microbiome, d...
Guo, Marissa Jin, Ning Pawlik, Timothy Cloyd, Jordan M
Published in
World Journal of Gastrointestinal Oncology
Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide, and up to 50% of patients with CRC develop colorectal liver metastases (CRLM). For these patients, surgical resection remains the only opportunity for cure and long-term survival. Over the past few decades, outcomes of patients with metastatic CRC have impro...
Cominardi, Anna Tamanini, Giacomo Brighi, Nicole Fusaroli, Pietro Lisotti, Andrea
Published in
World Journal of Gastrointestinal Oncology
Gastric outlet obstruction (GOO) is a clinical syndrome characterized by postprandial vomiting, abdominal pain, bloating and, in advanced cases, by weight loss secondary to inadequate oral intake. This clinical entity may be caused by mechanical obstruction, either benign or malignant, or by motility disorders. In this review we will focus on malig...
Hoskins, Brett Wasuwanich, Paul Scheimann, Ann O Karnsakul, Wikrom
Published in
World Journal of Gastrointestinal Oncology
Based on systematic review and meta-analysis, the risk for developing cancers in patients with cystic fibrosis (CF) is known to be significantly greater than in the general population, including site-specific cancers of the esophagus, small bowel, colon, liver, biliary tract, and pancreas. An even higher risk has been found in patients who have sev...
Mattos, Ângelo Z Debes, Jose D Boonstra, Andre Vogel, Arndt Mattos, Angelo A
Published in
World Journal of Gastrointestinal Oncology
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers and one of the main causes of cancer-related deaths worldwide. Most HCCs develop in an inflammatory microenvironment, and mounting evidence emphasizes the importance of immune aspects in hepatocarcinogenesis. In normal physiology, both innate and adaptive immune responses are respo...
