Herrero, Mercedes Ciérvide, Raquel Calle-Purón, Maria Elisa Valero, Javier Buelga, Paula Rodriguez-Bertos, Isabel Benassi, Leticia Montero, Angel
Published in
World Journal of Clinical Oncology
BACKGROUND Axillary sentinel lymph node biopsy (SLNB) is standard treatment for patients with clinically and pathological negative lymph nodes. However, the role of completion axillary lymph node dissection (cALND) following positive sentinel lymph node biopsy (SLNB) is debated. AIM To identify a subgroup of women with high axillary tumor burden un...
Ramirez, Robert A Thomas, Katharine Jacob, Aasems Lin, Karen Bren-Mattison, Yvette Chauhan, Aman
Published in
World Journal of Clinical Oncology
Pulmonary neuroendocrine neoplasms (NENs) represent a minority of lung cancers and vary from slower growing pulmonary carcinoid (PC) tumors to aggressive small cell lung cancer (SCLC). While SCLC can account for up to 15% of lung cancer, PCs are uncommon and represent about 2% of lung cancers. Surgical resection is the standard of care for early-st...
Cui, Di Cheung, Annie LM
Published in
World Journal of Clinical Oncology
Esophageal squamous cell carcinoma (ESCC) is the major subtype of esophageal cancer that is prevalent in Eastern Asia. Despite recent advances in therapy, the outcome of ESCC patients is still dismal. MicroRNAs (miRNAs) are non-coding RNAs which can negatively modulate gene expression at the post-transcriptional level. The involvement and roles of ...
Ramos, Marcus Fernando Kodama Pertille Pereira, Marina Alessandra de Mello, Evandro Sobroza Cirqueira, Cinthya dos Santos Zilberstein, Bruno Alves, Venancio Avancini Ferreira Ribeiro-Junior, Ulysses Cecconello, Ivan
Published in
World Journal of Clinical Oncology
BACKGROUND Gastric cancer (GC) is a highly heterogeneous disease, and the identification of molecular subtyping of gastric adenocarcinoma emerged as a promising option to define therapeutic strategies and prognostic subgroups. However, the costs and technical complexity of molecular methodologies remains an obstacle to its adoption, and their clini...
Lang, Sven Arke Bednarsch, Jan Czigany, Zoltan Joechle, Katharina Kroh, Andreas Amygdalos, Iakovos Strnad, Pavel Bruns, Tony Heise, Daniel Ulmer, Florian
...
Published in
World Journal of Clinical Oncology
Liver transplantation for malignant disease has gained increasing attention as part of transplant oncology. Following the implementation of the Milan criteria, hepatocellular carcinoma (HCC) was the first generally accepted indication for transplantation in patients with cancer. Subsequently, more liberal criteria for HCC have been developed, and r...
Saarenheimo, Jatta Andersen, Heidi Eigeliene, Natalja Jekunen, Antti P
Published in
World Journal of Clinical Oncology
Over the last twenty years, with the development of gene-driven therapies, numerous new drugs have entered clinical use. Very few of these new drugs are suitable for a large number of patients, and all require molecular genetic testing. In lung cancer, gene-targeted therapy has evolved rapidly and has placed demands on the development of diagnostic...
Luna, Javier Bobo, Andrea Cabrera-Rodriguez, Joaquín José Pagola, María Martín-Martín, Margarita Ruiz, María Ángeles González Montijano, Miguel Rodríguez, Aurora Pelari-Mici, Lira Corbacho, Almudena
...
Published in
World Journal of Clinical Oncology
Malignant pleural mesothelioma (MPM) is a rare tumor with poor prognosis and rising incidence. Palliative care is common in MPM as radical treatment with curative intent is often not possible due to metastasis or extensive locoregional involvement. Numerous therapeutic advances have been made in recent years, including the use of less aggressive su...
Valencia, Guillermo Arturo Rioja, Patricia Morante, Zaida Araujo, Jhajaira M Vallejos, Heberth Daniel Guerra, Henry Gomez, Henry L
Published in
World Journal of Clinical Oncology
BACKGROUND Currently, the detection of PIK3CA mutations is of special interest in personalized medicine because it is frequently found in triple-negative breast cancer (TNBC). The PI3KCA mutation is an independent negative prognostic factor for survival in metastatic breast cancer, and its prognostic value in liquid biopsy as a biomarker of treatme...
Tecalco-Cruz, Angeles C Abraham-Juárez, María Jazmin Solleiro-Villavicencio, Helena Ramírez-Jarquín, Josué Orlando
Published in
World Journal of Clinical Oncology
TRIM25 is emerging as a central factor in breast cancer due to its regulation and function. In particular, it has been shown that: (1) Estrogens modulate TRIM25 gene expression; (2) TRIM25 has activity as an E3-ligase enzyme for ubiquitin; and (3) TRIM25 is also an E3 ligase for interferon-stimulated gene 15 protein in the ISGylation system. Conseq...
Zhu, Yun Cheung, Annie Lai Man
Published in
World Journal of Clinical Oncology
Esophageal squamous cell carcinoma (ESCC) is a highly malignant disease that has a poor prognosis. Its high lethality is mainly due to the lack of symptoms at early stages, which culminates in diagnosis at a late stage when the tumor has already metastasized. Unfortunately, the common cancer biomarkers have low sensitivity and specificity in esopha...
