Roumani, Foteini Azinheiro, Sarah Sousa, Hugo Sousa, Ana Timóteo, Mafalda Varandas, Tatiana Fonseca-Silva, Daniela Baldaque, Inês Carvalho, Joana Prado, Marta
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Published in
Viruses
SARS-CoV-2 is the coronavirus responsible for COVID-19, which has spread worldwide, affecting more than 200 countries, infecting over 140 million people in one year. The gold standard to identify infected people is RT-qPCR, which is highly sensitive, but needs specialized equipment and trained personnel. The demand for these reagents has caused sho...
Hamer, Sarah A Pauvolid-Corrêa, Alex Zecca, Italo B Davila, Edward Auckland, Lisa D Roundy, Christopher M Tang, Wendy Torchetti, Mia Kim Killian, Mary Lea Jenkins-Moore, Melinda
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Published in
Viruses
Understanding the ecological and epidemiological roles of pets in the transmission of SARS-CoV-2 is critical for animal and human health, identifying household reservoirs, and predicting the potential enzootic maintenance of the virus. We conducted a longitudinal household transmission study of 76 dogs and cats living with at least one SARS-CoV-2-i...
Turkki, Vesa Alppila, Elisa Ylä-Herttuala, Seppo Lesch, Hanna P
Published in
Viruses
Virus particle concentration is a critical piece of information for virology, viral vaccines and gene therapy research. We tested a novel nanoparticle counting device, "Videodrop", for its efficacy in titering and characterization of virus particles. The Videodrop nanoparticle counter is based on interferometric light microscopy (ILM). The method a...
Motlou, Thopisang P Williams, June Venter, Marietjie
Published in
Viruses
The Orthobunyavirus genus, family Peribunyaviridae, contains several important emerging and re-emerging arboviruses of veterinary and medical importance. These viruses may cause mild febrile illness, to severe encephalitis, fetal deformity, abortion, hemorrhagic fever and death in humans and/or animals. Shuni virus (SHUV) is a zoonotic arbovirus th...
Pucci, Fabrizio Rooman, Marianne
Published in
Viruses
The understanding of the molecular mechanisms driving the fitness of the SARS-CoV-2 virus and its mutational evolution is still a critical issue. We built a simplified computational model, called SpikePro, to predict the SARS-CoV-2 fitness from the amino acid sequence and structure of the spike protein. It contains three contributions: the inter-hu...
Asfor, Amin S Nazki, Salik Reddy, Vishwanatha R A P Campbell, Elle Dulwich, Katherine L Giotis, Efstathios S Skinner, Michael A Broadbent, Andrew J
Published in
Viruses
In order to better understand differences in the outcome of infectious bursal disease virus (IBDV) infection, we inoculated a very virulent (vv) strain into White Leghorn chickens of inbred line W that was previously reported to experience over 24% flock mortality, and three inbred lines (15I, C.B4 and 0) that were previously reported to display no...
Haberland, Annekathrin Krylova, Oxana Nikolenko, Heike Göttel, Peter Dallmann, Andre Müller, Johannes Weisshoff, Hardy
Published in
Viruses
COVID-19 is a pandemic respiratory disease that is caused by the highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Anti-SARS-CoV-2 antibodies are essential weapons that a patient with COVID-19 has to combat the disease. When now repurposing a drug, namely an aptamer that interacts with SARS-CoV-2 proteins for COVID-19 ...
Humphreys, John M Young, Katherine I Cohnstaedt, Lee W Hanley, Kathryn A Peters, Debra P C
Published in
Viruses
West Nile virus (WNV) is the most common arthropod-borne virus (arbovirus) in the United States (US) and is the leading cause of viral encephalitis in the country. The virus has affected tens of thousands of US persons total since its 1999 North America introduction, with thousands of new infections reported annually. Approximately 1% of humans inf...
Igarashi, Manabu Hirokawa, Takatsugu Takadate, Yoshihiro Takada, Ayato
Published in
Viruses
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the endosomal receptor Niemann-Pick C1 (NPC1) protein. The crystal structure analysis of the cleaved G...
Näsman, Anders Holzhauser, Stefan Kostopoulou, Ourania N Zupancic, Mark Ährlund-Richter, Andreas Du, Juan Dalianis, Tina
Published in
Viruses
The incidence of Human-papillomavirus-positive (HPV+) tonsillar and base-of-tongue squamous cell carcinoma (TSCC and BOTSCC, respectively) is increasing epidemically, but they have better prognosis than equivalent HPV-negative (HPV-) cancers, with roughly 80% vs. 50% 3-year disease-free survival, respectively. The majority of HPV+ TSCC and BOTSCC p...
