De Maio, Flavio Salustri, Alessandro Battah, Basem Palucci, Ivana Marchionni, Federica Bellesi, Silvia Palmieri, Valentina Papi, Massimiliano Kramarska, Eliza Sanguinetti, Maurizio
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Published in
Virulence
PE_PGRS proteins of Mycobacterium tuberculosis (Mtb) constitute a large family of complex modular proteins whose role is still unclear. Among those, we have previously shown, using the heterologous expression in Mycobacterium smegmatis, that PE_PGRS3 containing a unique arginine-rich C-terminal domain, promotes adhesion to host cells. In this study...
Rocha, Rebeca Froes Del Sarto, Juliana L Gomes, Giovanni F Gonçalves, Mariana P Rachid, Milene A Smetana, Juliana H C Souza, Daniele G Teixeira, Mauro Martins Marques, Rafael Elias
Published in
Virulence
St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes severe neurological disease in humans. SLEV replication in the central nervous system (CNS) induces the local production of interferons (IFNs), which are attributed to host protection. The antiviral response to SLEV infection in the CNS is not completely unders...
Yamaoka, Satoko Ebihara, Hideki
Published in
Virulence
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While there have been six virus species classified, which each have a single type virus in the genus Ebolavirus, CFRs of ebolavirus infections vary among viruses belonging to eac...
Yiwen, Chen Yueyue, Wu Lianmei, Qin Cuiming, Zhu Xiaoxing, You
Published in
Virulence
Mycoplasmas, the smallest bacteria lacking a cell wall, can cause various diseases in both humans and animals. Mycoplasmas harbor a variety of virulence factors that enable them to overcome numerous barriers of entry into the host; using accessory proteins, mycoplasma adhesins can bind to the receptors or extracellular matrix of the host cell. Alth...
Dileepan, Mythili Di, Da Huang, Qinfeng Ahmed, Shamim Heinrich, Daniel Ly, Hinh Liang, Yuying
Published in
Virulence
The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 is continuing to spread globally. SARS-CoV-2 infections of feline and canine species have also been reported. However, it is not entirely clear to what extent natural SARS-CoV-2 infection of pet dogs and cats is in households. We have developed enzyme-linked immunosorbent assays (ELISAs) us...
Van Ende, Mieke Timmermans, Bea Vanreppelen, Giel Siscar-Lewin, Sofía Fischer, Daniel Wijnants, Stefanie Romero, Celia Lobo Yazdani, Saleh Rogiers, Ona Demuyser, Liesbeth
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Published in
Virulence
Candida glabrata is an opportunistic human fungal pathogen and is frequently present in the human microbiome. It has a high relative resistance to environmental stresses and several antifungal drugs. An important component involved in microbial stress tolerance is trehalose. In this work, we characterized the three C. glabrata trehalase enzymes Ath...
Mettier, Joëlle Marc, Daniel Sedano, Laura Da Costa, Bruno Chevalier, Christophe Le Goffic, Ronan
Published in
Virulence
Influenza A viruses cause important diseases in both human and animal. The PB1-F2 protein is a virulence factor expressed by some influenza viruses. Its deleterious action for the infected host is mostly described in mammals, while the available information is scarce in avian hosts. In this work, we compared the effects of PB1-F2 in avian and mamma...
Chiu, Sue-Fen Teng, Kai-Wen Wang, Po-Chuan Chung, Hsin-Yu Wang, Chun-Jen Cheng, Hui-Chun Kao, Mou-Chieh
Published in
Virulence
Helicobacter pylori infection is linked to serious gastric-related diseases including gastric cancer. However, current therapies for treating H. pylori infection are challenged by the increased antibiotic resistance of H. pylori. Therefore, it is in an urgent need to identify novel targets for drug development against H. pylori infection. In this s...
Côrtes, Marina Farrel Botelho, Ana Maria N Bandeira, Paula Terra Mouton, William Badiou, Cedric Bes, Michèle Lima, Nicholas C B Soares, André Elias R Souza, Rangel C Almeida, Luiz G P
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Published in
Virulence
Methicillin-resistant Staphylococcus aureus (MRSA) of the ST1-SCCmecIV lineage has been associated with community-acquired (CA) infections in North America and Australia. In Brazil, multi-drug resistant ST1-SCCmecIV MRSA has emerged in hospital-associated (HA) diseases in Rio de Janeiro. To understand these epidemiological differences, genomic and ...
Xie, Quan Wang, Weikang Li, Luyuan Kan, Qiuqi Fu, Hui Geng, Tuoyu Li, Tuofan Wan, Zhimin Gao, Wei Shao, Hongxia
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Published in
Virulence
The outbreaks of hepatitis-hydropericardium syndrome (HPS) caused by the highly pathogenic serotype 4 fowl adenovirus (FAdV-4) have caused a huge economic loss to the poultry industry globally since 2013. Although the Fiber-2 has been identified as a key virulent related factor for FAdV-4, little is known about its molecular basis. In this study, w...
