Rocha, Rebeca Froes Del Sarto, Juliana L Gomes, Giovanni F Gonçalves, Mariana P Rachid, Milene A Smetana, Juliana H C Souza, Daniele G Teixeira, Mauro Martins Marques, Rafael Elias
Published in
Virulence
St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes severe neurological disease in humans. SLEV replication in the central nervous system (CNS) induces the local production of interferons (IFNs), which are attributed to host protection. The antiviral response to SLEV infection in the CNS is not completely unders...
Van Ende, Mieke Timmermans, Bea Vanreppelen, Giel Siscar-Lewin, Sofía Fischer, Daniel Wijnants, Stefanie Romero, Celia Lobo Yazdani, Saleh Rogiers, Ona Demuyser, Liesbeth
...
Published in
Virulence
Candida glabrata is an opportunistic human fungal pathogen and is frequently present in the human microbiome. It has a high relative resistance to environmental stresses and several antifungal drugs. An important component involved in microbial stress tolerance is trehalose. In this work, we characterized the three C. glabrata trehalase enzymes Ath...
Ma, Shuangshuang Jiang, Lingyan Wang, Jingting Liu, Xiaoqian Li, Wanwu Ma, Shuai Feng, Lu
Published in
Virulence
The intracellular pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) exploits host macrophage as a crucial survival and replicative niche. To minimize host immune response stimulated by flagellin, the expression of flagellar genes is downregulated during S. Typhimurium growth within host macrophages. However, the underlying mechanism...
Bao, Yanqing Wang, Lin Sun, Jianjun
Published in
Virulence
Current genetic studies (e.g. gene knockout) have suggested that EsxA and EsxB function as secreted virulence factors that are essential for Mycobaterium tuberculosis (Mtb) intracellular survival, specifically in mediating phagosome rupture and translocation of Mtb to the cytosol of host cells, which further facilitates Mtb intracellular replicatin...
Shang, Jian Zheng, Yuan Mo, Jiayin Wang, Wenbiao Luo, Zhen Li, Yongkui Chen, Xulin Zhang, Qiwei Wu, Kailang Liu, Weiyong
...
Published in
Virulence
Toll-like receptors (TLRs) are essential for the protection of the host from pathogen infections by initiating the integration of contextual cues to regulate inflammation and immunity. However, without tightly controlled immune responses, the host will be subjected to detrimental outcomes. Therefore, it is important to balance the positive and nega...
Rojas, José M. Pascual, Elena Wattegedera, Sean R. Avia, Miguel Santiago, César Martín, Verónica Entrican, Gary Sevilla, Noemí
Published in
Virulence
The toll-like receptor (TLR) family comprises both cell-surface and intracellular receptors that recognize different types of pathogen-associated molecular patterns (PAMPs) leading to the production of pro-inflammatory cytokines and subsequent development of adaptive immunity. TLR2 is a cell-surface receptor initially thought to act as a bacterial ...
Miao, Yujie Han, Peiyu Hua, Dong Zhou, Renwu Guan, Zhengbing Lv, Qing Dai, Xiaofeng
Published in
Virulence
Enhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve the desirable cellular outcome, was shown to be effective in enhancing virus propagation, where bovine rhinotrachieitis virus and Madin-Darby Bovine ...
Krachler, Anne Marie Sirisaengtaksin, Natalie Monteith, Pauline Paine, C. E. Timothy Coates, Christopher J. Lim, Jenson
Published in
Virulence
Adhesins facilitate bacterial colonization and invasion of host tissues and are considered virulence factors, but their impact on immune-mediated damage as a driver of pathogenesis remains unclear. Yersinia pseudotuberculosis encodes for a m ultivalent a dhesion m olecule (MAM), a mammalian cell entry (MCE) family protein and adhesin. MAMs are wide...
Hou, Xiaoyue Han, Lu An, Baoju Cai, Jun
Published in
Virulence
Vip3Aa is an insecticidal protein that can effectively control certain lepidopteran pests and has been used widely in biological control. However, the mechanism of action of Vip3Aa is unclear. In the present study, we showed that Vip3Aa could cause autophagy in Sf9 cells, which was confirmed by the increased numbers of GFP-Atg8 puncta, the appearan...
Wang, Guanbo Glaser, Lena Scott, Nichollas E. Fathy Mohamed, Yasmine Ingram, Rebecca Laroucau, Karine Valvano, Miguel A.
Published in
Virulence
We recently described a protein O -glycosylation pathway conserved in all species of the Burkholderia genus that results in the synthesis and incorporation of a trisaccharide glycan to membrane-exported proteins. Here, we exploited this system to construct and evaluate a diagnostic tool for glanders. Burkholderia mallei , the causative agent of gla...
