Kerckhoffs, K G P Aallali, T Ambarus, C A Sigurdsson, V Jansen, A M L Blokx, W A M
Published in
Virchows Archiv : an international journal of pathology
The molecular background of a significant proportion of spitzoid neoplasms is still unknown. Recently, activating mutations in MAP2K1 have been described in a few spitzoid lesions, but not in benign Spitz nevi. We report four cases of melanocytic tumors with spitzoid features in which a MAP2K1 mutation was detected. The lesions did not show a singl...
Wang, Xudong Zhang, Xiaohui Pan, Wenling Han, Yuedong Li, Yanwei Sun, Haibin Hogendoorn, Pancras C W Cheng, Hong
Published in
Virchows Archiv : an international journal of pathology
Tumour-to-tumour metastasis is very unusual and has been defined as a tumour metastasis into another histologically different tumour. It is extremely rare in bone. We report a case of lung squamous cell carcinoma metastasized to an enchondroma in the femur of a patient with Ollier disease. A 60-year-old female had a history of a poorly differentiat...
Kawasaki, Tomonori Kaira, Kyoichi
Published in
Virchows Archiv : an international journal of pathology
Herein, we describe the first cases of neuroendocrine (NE) phenotype mammary carcinomas in which the NE nature of the tumors was confirmed only by insulinoma-associated protein 1 (INSM1), without expressions of traditional "gold standard" NE indicators. This is also the first analysis to use INSM1, a promising antibody with high sensitivity and spe...
Babaryka, G Janßen, S Winand, E Häberle, L Esposito, I
Published in
Virchows Archiv : an international journal of pathology
This article presents an evaluation of 4255 autopsy cases recorded at the Dusseldorf Pathology Institute in the years 1914 to 1918. Diagnoses were coded according to the International Classification of Diseases, 10th edition (ICD-10), and the contemporaneous history of the Pathology Institute was reviewed. We found a proportion of 54.1% adults and ...
Pereira, Marina Alessandra Ramos, Marcus Fernando Kodama Pertille Dias, André Roncon Ribeiro, Renan Cardili, Leonardo Zilberstein, Bruno Cecconello, Ivan Ribeiro, Ulysses Jr de Mello, Evandro Sobroza de Castria, Tiago Biachi
...
Published in
Virchows Archiv : an international journal of pathology
The combined positive score (CPS) and tumor proportion score (TPS) have been developed to evaluate programmed death ligand-1 (PD-L1) expression, especially due to the potential benefit of the targeted therapy. However, the prognostic value of PD-L1 scoring systems in gastric cancer (GC) remains unclear. This study aimed to evaluate PD-L1 expression...
Sano, Tomoyasu Kato, Masashi Sassa, Naoto Sadachi, Ryo Hirakawa, Akihiro Kamihira, Osamu Hirabayashi, Tsuyoki Nishikimi, Toshinori Katsuno, Satoshi Kimura, Toru
...
Published in
Virchows Archiv : an international journal of pathology
Whether pT3 urothelial carcinoma of the renal pelvis (UCRP) and urothelial carcinoma of the ureter (UCU) have the same prognosis is controversial, this study compared the prognosis of pT3 UCRP with that of pT3 UCU. We retrospectively evaluated 954 patients who underwent nephroureterectomy at our institutions between January 1983 and December 2017. ...
Smeets, Silke Staels, Willem Stangé, Geert Gillard, Pieter De Leu, Nico In't Veld, Peter
Published in
Virchows Archiv : an international journal of pathology
Insulitis is a characteristic inflammatory lesion consisting of immune cell infiltrates around and within the pancreatic islets of patients with recent-onset type 1 diabetes (T1D). The infiltration is typically mild, both in terms of the number of infiltrating cells and the number of islets affected. Here, we present an unusual histopathological ca...
Sbaraglia, Marta Zanatta, Lucia Toffolatti, Luisa Spallanzani, Andrea Bertolini, Federica Mattioli, Francesco Lami, Federico Presutti, Livio Dei Tos, Angelo P
Published in
Virchows Archiv : an international journal of pathology
Malignant gastrointestinal neuroectodermal tumor (M-GNET) and clear cell sarcoma (CCS) of soft tissue represent closely related, extremely rare, malignant mesenchymal neoplasm of uncertain differentiation. Both entities are characterized genetically by the same molecular alterations represented by the presence of EWSR1-ATF1 and, more rarely, EWSR1-...
Alpert, Lindsay Setia, Namrata Ko, Huaibin Mabel Lagana, Stephen M Pittman, Meredith E Johncilla, Melanie Drage, Michael G Zhao, Lei Salomao, Marcela A Liao, Xiaoyan
...
Published in
Virchows Archiv : an international journal of pathology
The diagnosis of inflammatory bowel disease (IBD)-associated dysplasia is challenging, and past studies have demonstrated considerable interobserver variability in such diagnoses. This study aimed to assess interobserver agreement in IBD dysplasia diagnoses among subspecialty GI pathologists and to explore the impact of mentorship on diagnostic var...
Stražar, Klemen Šekoranja, Daja Matjašič, Alenka Zupan, Andrej Snoj, Žiga Martinčič, David Pižem, Jože
Published in
Virchows Archiv : an international journal of pathology
Intraarticular nodular fasciitis arising in the joint synovium is an uncommon lesion. Most cases have been reported in the knee and rarely in other joints. A USP6 gene fusion has so far been documented in only four cases of intraarticular nodular fasciitis, three were located in the knee and one in the proximal interphalangeal joint. In all three c...
