Uccella, Silvia
Published in
Virchows Archiv : an international journal of pathology
Neuroendocrine neoplasms of the breast (Br-NENs) are rare tumors of the mammary gland. Their definition and classification have been a matter of discussion for more than half a century, as they present some degree of overlap with other malignancies in the mammary gland. The recent evolutions in the understanding of the pathogenesis of neuroendocrin...
Kuo, Chien-Tzu Kao, Yu-Chien Huang, Hsuan-Ying Hsiao, Cheng-Hsiang Lee, Jen-Chieh
Published in
Virchows Archiv : an international journal of pathology
Malignant gastrointestinal neuroectodermal tumor (MGNET) is a sarcoma typically involving the gastrointestinal tract with neuroectodermal differentiation and EWSR1-ATF1/CREB1 fusions. Recently, rare MGNET cases were reported in extragastrointestinal sites. We identified 2 cases of MGNET arising in unprecedented laryngeal and intracranial locations,...
Yoshida, Hiroshi Asami, Yuka Kobayashi-Kato, Mayumi Tanase, Yasuhito Uno, Masaya Ishikawa, Mitsuya Shiraishi, Kouya Kato, Tomoyasu
Published in
Virchows Archiv : an international journal of pathology
This study aimed to clarify the genetic features of endometrioid-type endometrial cancer arising in adenomyosis (EC-AIA) using targeted sequencing and immunohistochemistry (IHC) for both carcinoma and adjacent adenomyosis tissues. We identified three endometrioid-type EC-AIAs in 689 patients with endometrial cancer; two exhibited grade 3 endometrio...
Kim, Han-Na Kim, Dae Sik Jeon, Min Ji Yu, Eun Sang Choi, Chul-Won Ko, Young Hyeh
Published in
Virchows Archiv : an international journal of pathology
Epstein-Barr virus-infected B cells are found at high frequency in peripheral T cell lymphoma. Herein, we report a case involving excessive EBV-positive B cells accompanying peripheral T cell lymphoma, not otherwise specified in the nasopharynx masquerading as nasopharyngeal extranodal NK/T cell lymphoma. A large number of Epstein-Barr virus-infect...
Chen, Chien-Heng Chang, Kung-Chao Chuang, Chieh-Han Fu, Jing-Tong Huang, Hsuan-Ying
Published in
Virchows Archiv : an international journal of pathology
Nuclear receptor coactivator (NCOA) family gene fusions have been increasingly discovered in diverse mesenchymal neoplasms, while PRRX1-NCOA-fused fibroblastic tumors still remain insufficiently characterized. We herein present two additional PRRX1-NOCA1-positive cases sharing lobulated hypocellular growth of innocuous spindle-to-stellate cells in ...
Polónia, António Canelas, Carolina Caramelo, Ana
Published in
Virchows Archiv : an international journal of pathology
We aimed to document the pathological characteristics of breast cancer (BC) cases with different scores of HER2 by immunohistochemistry (IHC), as well as to establish a relationship between HER2 expression and HER2 amplification by in situ hybridization (ISH). A cohort of 258 primary BC cases was evaluated for HER2 gene amplification with bright-fi...
Luchini, Claudio Mafficini, Andrea Chatterjee, Deyali Piredda, Maria L Sciammarella, Concetta Navale, Pooja Malleo, Giuseppe Mattiolo, Paola Marchegiani, Giovanni Pea, Antonio
...
Published in
Virchows Archiv : an international journal of pathology
Pancreatic ductal adenocarcinoma (PDAC) with microsatellite instability (MSI)/defective mismatch repair (dMMR) is the only subtype of pancreatic cancer with potential response to immunotherapy. Here, we report the histo-molecular characterization of MSI/dMMR PDAC with immunohistochemistry, MSI-based PCR, and next-generation sequencing. Five paradig...
Magno, Giovanni Zampieri, Fabio Thiene, Gaetano Basso, Cristina Zorzi, Federico Della Barbera, Mila Zanatta, Alberto
Published in
Virchows Archiv : an international journal of pathology
A unique specimen of argyria is preserved in the Morgagni Museum of Pathological Anatomy at the University of Padua (Italy). It is a stuffed head belonging to a man who decided to cure his syphilis by himself with the so-called infernal stone (silver nitrate) every day for years, thus developing argyria in the second half of the nineteenth century....
Hladek, Luca Bankov, Katrin von der Grün, Jens Filmann, Natalie Demes, Melanie Vallo, Stefan Wild, Peter J Winkelmann, Ria
Published in
Virchows Archiv : an international journal of pathology
Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapt...
Lerch, Julia M Pai, Rish K Brown, Ian Gill, Anthony J Jain, Dhanpat Kővári, Bence Kushima, Ryoji Sheahan, Kieran Slavik, Tomas Srivastava, Amitabh
...
Published in
Virchows Archiv : an international journal of pathology
The extent of gastric intestinal metaplasia (GIM) can be used to determine the risk of gastric cancer. Eleven international gastrointestinal expert pathologists estimated the extent of GIM on haematoxylin and eosin (H&E)- and Alcian blue-Periodic acid Schiff (AB-PAS)-stained slides of 46 antrum biopsies in 5% increments. Interobserver agreement was...
