Toward an effective use of β-catenin immunohistochemistry in the evaluation of challenging melanocytic lesions
Published in Virchows Archiv
HER2 testing in gastric cancer diagnosis: insights on variables influencing HER2-positivity from a large, multicenter, o...
...Published in Virchows Archiv
HER2 testing in metastatic gastric or gastroesophageal junction cancer (mGC/mGEJC) is standard practice. Variations in HER2-positivity rates suggest factors affecting test quality; however, the influence of patient-, tumor-, and laboratory-related factors on HER2-positivity rates remains unknown. This observational, prospective study collected rout...
Intraductal carcinoma of the prostate: a critical re-appraisal
Published in Virchows Archiv
Intraductal carcinoma of the prostate gland (IDCP), which is now categorised as a distinct entity by WHO 2016, includes two biologically distinct diseases. IDCP associated with invasive carcinoma (IDCP-inv) generally represents a growth pattern of invasive prostatic adenocarcinoma while the rarely encountered pure IDCP is a precursor of prostate ca...
Cancer immunology, inflammation, and tolerance: an introduction
Published in Virchows Archiv
The International Society of Urological Pathology Education web—a web-based system for training and testing of pathologi...
...Published in Virchows Archiv
Pathology training resources remain scarce in many parts of the world. With rapid economic development comes the need to educate new pathologists to meet the medical care demands. Our aim was to set up a cost-effective system for training and testing the diagnostic skills of pathologists. Pathologists in nine countries in Asia and South America wer...
Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer
...Published in Virchows Archiv
Metastatic lung cancers from the colon and rectum (MLCR) frequently have necrotic components. The aim of this study is to elucidate clinicopathological factors associated with the amount of necrosis in MLCR. Ninety patients who underwent the first pulmonary metastasectomy for MLCR with a tumor diameter ≦ 3.0 cm and without chemotherapy were enrolle...
β-Catenin nuclear expression discriminates deep penetrating nevi from other cutaneous melanocytic tumors
Published in Virchows Archiv
Recent advances in genomics have improved the molecular classification of cutaneous melanocytic tumors. Among them, deep penetrating nevi (DPN) and plexiform nevi have been linked to joint activation of the MAP kinase and dysregulation of the β-catenin pathways. Immunohistochemical studies have confirmed cytoplasmic and nuclear expression of β-cate...
Two rare cases of endosalpingiosis in the axillary sentinel lymph nodes: evaluation of immunohistochemical staining and ...
Published in Virchows Archiv
Benign inclusions, such as endosalpingiosis, in an axillary sentinel lymph node (SLN) can be misdiagnosed as metastatic breast carcinoma. However, endosalpingiosis is rare in lymph nodes above the diaphragm. Among 792 patients with breast carcinoma who underwent sentinel lymph node biopsy at our center, 2 patients have experienced benign glandular ...
Recent success and limitations of immune checkpoint inhibitors for cancer: a lesson from melanoma
Published in Virchows Archiv
Several researches have been carried over the last few decades to understand of how cancer evades the immune system and thus to identify therapies that could directly act on patient’s immune system in the way of restore or induce a response to cancer. As a consequence, “cancer immunotherapy” is conquering predominantly the modern scenario of the fi...
Compact buds with biphasic differentiation and calcitonin-expressing neuroendocrine cells—previously unrecognized struct...
Published in Virchows Archiv
Immunophenotype of thyroglossal duct (TGD) cysts, including lining epithelium and thyroid remnants, is scarcely addressed in the literature. There is indirect evidence that C cells may be derived from progenitor cells of the midline thyroid primordium. This is supported by the recent concept of the endodermal origin of lateral thyroid anlagen and s...
