Liu, Yingqi Li, Rui Qiao, Songlin Chen, Xin-xin Deng, Ruiguang Zhang, Gaiping
Published in
Veterinary Research
Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant threat to the global swine industry. Porcine sialoadhesin (poSn) has been previously shown to mediate PRRSV attachment and internalization. In the current study, we report its unidentified role in antagonism of type I interferon (IFN) production during PRRSV infection. We ...
Li, Yalan Wang, Baiyan Zhu, Yaxin Tian, Zhihua Yang, Zhuo Duan, Jiaqi Wang, Zhongquan
Published in
Veterinary Research
The cysteine proteases of parasites are vital contributors that induce parasite migration to and invasion of host tissue. In this study, we analysed the cysteine protease ATG4B of Trichinella spiralis (TsATG4B) isolated from the soluble proteins of Trichinella spiralis (T. spiralis) adult worms to ascertain its biochemical properties and functions ...
Dai, Manman Xie, Tingting Liao, Ming Zhang, Xiquan Feng, Min
Published in
Veterinary Research
Interferon-stimulated genes (ISGs) play an important role in antiviral innate immune responses. Although many ISGs have been identified in mammals, researchers commonly recognize that many more ISGs are yet to be discovered. Current information is still very limited particularly for the systematic identification of type III ISGs. Similarly, current...
Parvin, Rokshana Schinkoethe, Jan Grund, Christian Ulrich, Reiner Bönte, Franziska Behr, Klaus P. Voss, Matthias Samad, Mohammed A. Hassan, Kareem E. Luttermann, Christine
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Published in
Veterinary Research
An intravenous pathogenicity index (IVPI) of > 1.2 in chickens or, in case of subtypes H5 and H7, expression of a polybasic hemagglutinin cleavage site (HACS), signals high pathogenicity (HP). Viruses of the H9N2-G1 lineage, which spread across Asia and Africa, are classified to be of low pathogenicity although, in the field, they became associated...
Wattegedera, Sean R. Livingstone, Morag Maley, Stephen Rocchi, Mara Lee, Susan Pang, Yvonne Wheelhouse, Nick M. Aitchison, Kevin Palarea-Albaladejo, Javier Buxton, David
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Published in
Veterinary Research
Ovine enzootic abortion (OEA) caused by the obligate intracellular bacterial pathogen Chlamydia abortus (C. abortus), is an endemic disease in most sheep-rearing countries worldwide. Following infection, C. abortus establishes a complex host–pathogen interaction with a latent phase in non-pregnant sheep followed by an active disease phase in the pl...
Jeklova, Edita Leva, Lenka Matiasovic, Jan Ondrackova, Petra Kummer, Vladimir Faldyna, Martin
Published in
Veterinary Research
Encephalitozoonosis is a common infectious disease widely spread among rabbits. Encephalitozoon cuniculi, is considered as a zoonotic and emerging pathogen capable of infecting both immunocompetent and immunocompromised hosts. The aim of the study was to describe in detail the spread of the E. cuniculi in a rabbit organism after experimental infect...
Blasdell, Kim R. Davis, Steven S. Voysey, Rhonda Bulach, Dieter M. Middleton, Deborah Williams, Sinead Harmsen, Margaret B. Weir, Richard P. Crameri, Sandra Walsh, Susan J.
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Published in
Veterinary Research
Bovine ephemeral fever is a vector-borne disease of ruminants that occurs in tropical and sub-tropical regions of Africa, Asia and Australia. The disease is caused by a rhabdovirus, bovine ephemeral fever virus (BEFV), which occurs as a single serotype globally. Although several other closely related ephemeroviruses have been isolated from cattle a...
Quan, Guomei Xia, Pengpeng Lian, Siqi Wu, Yunping Zhu, Guoqiang
Published in
Veterinary Research
Zinc is the second trace element of living organisms after iron. Given its crucial importance, mammalian hosts restrict the bioavailability of Zinc ions (Zn2+) to bacterial pathogens. As a countermeasure, pathogens utilize high affinity Zn2+ transporters, such as ZnuACB to compete with the host for zinc. It is essential for bacteria to maintain zin...
Pham, Thu Thao Ban, Jihye Hong, Yeojin Lee, Jiae Vu, Thi Hao Truong, Anh Duc Lillehoj, Hyun S. Hong, Yeong Ho
Published in
Veterinary Research
MicroRNAs (miRNAs) are small non-coding RNAs that contribute to host immune response as post-transcriptional regulation. The current study investigated the biological role of the chicken (Gallus gallus) microRNA-200a-3p (gga-miR-200a-3p), using 2 necrotic enteritis (NE) afflicted genetically disparate chicken lines, 6.3 and 7.2, as well as the mech...
Ge, Shikun Xu, Long Li, Ben Zhong, Fagang Liu, Xiang Zhang, Xiaoying
Published in
Veterinary Research
Canine parvovirus (CPV) can cause acute and highly contagious bloody enteritis in dog. To obtain antibodies against CPV, hens were immunized with virus-like particles (VLP) of CPV-VP2. The IgY single chain fragment variables (scFv) were generated by T7 phage display system and expressed in E. coli system. The titer of the primary scFv library reach...
