Senevirathne, Amal Hewawaduge, Chamith Lee, John Hwa
Published in
Veterinary Research
The present study employs the Brucella abortus L7/L12 antigen in a Salmonella secretion platform and investigates its ability to induce protective immune responses against wild type challenge in BALB/c mice. The highly conserved L7/L12 open reading frame was PCR amplified from B. abortus and cloned into a prokaryotic expression vector, pJHL65, dire...
Zhang, Zhonghua Jiang, Shan Liu, Yun Sun, Yu Yu, Peixin Gong, Qianwen Zeng, Hang Li, Yihao Xue, Feng Zhuge, Xiangkai
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Published in
Veterinary Research
Avian pathogenic Escherichia coli (APEC), a pathotype of extraintestinal pathogenic E. coli, causes one of the most serious infectious diseases of poultry and shares some common virulence genes with neonatal meningitis-associated E. coli. TonB-dependent receptors (TBDRs) are ubiquitous outer membrane β-barrel proteins; they play an important role i...
Forletti, Agustina Lützelschwab, Claudia María Cepeda, Rosana Esteban, Eduardo N. Gutiérrez, Silvina Elena
Published in
Veterinary Research
Cattle maintaining a low proviral load (LPL) status after bovine leukaemia virus (BLV) infection have been recognized as BLV controllers and non-transmitters to uninfected cattle in experimental and natural conditions. LPL has been associated with host genetics, mainly with the BoLA class II DRB3 gene. The aim of this work was to study the kinetics...
Bryson, Karen Jane Garrido, Damien Esposito, Marco McLachlan, Gerry Digard, Paul Schouler, Catherine Guabiraba, Rodrigo Trapp, Sascha Vervelde, Lonneke
Published in
Veterinary Research
The avian respiratory tract is a common entry route for many pathogens and an important delivery route for vaccination in the poultry industry. Immune responses in the avian lung have mostly been studied in vivo due to the lack of robust, relevant in vitro and ex vivo models mimicking the microenvironment. Precision-cut lung slices (PCLS) have the ...
Salvesen, Øyvind Espenes, Arild Reiten, Malin R. Vuong, Tram T. Malachin, Giulia Tran, Linh Andréoletti, Olivier Olsaker, Ingrid Benestad, Sylvie L. Tranulis, Michael A.
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Published in
Veterinary Research
Prion diseases are progressive and fatal, neurodegenerative disorders described in humans and animals. According to the “protein-only” hypothesis, the normal host-encoded prion protein (PrPC) is converted into a pathological and infectious form (PrPSc) in these diseases. Transgenic knockout models have shown that PrPC is a prerequisite for the deve...
Gil, Carmen Latasa, Cristina García-Ona, Enrique Lázaro, Isidro Labairu, Javier Echeverz, Maite Burgui, Saioa García, Begoña Lasa, Iñigo Solano, Cristina
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Published in
Veterinary Research
Salmonellosis is the second most common food-borne zoonosis in the European Union, with pigs being a major reservoir of this pathogen. Salmonella control in pig production requires multiple measures amongst which vaccination may be used to reduce subclinical carriage and shedding of prevalent serovars, such as Salmonella enterica serovar Typhimuriu...
Li, Yuchen Wu, Qingxin Jin, Yuxin Yang, Qian
Published in
Veterinary Research
Interleukin-11 (IL-11), a well-known anti-inflammatory factor, provides protection from intestinal epithelium damage caused by physical or chemical factors. However, little is known of the role of IL-11 during viral infections. In this study, IL-11 expression at mRNA and protein levels were found to be high in Vero cells and the jejunum of piglets ...
Cui, Tingting Theuns, Sebastiaan Xie, Jiexiong Nauwynck, Hans J.
Published in
Veterinary Research
Intestinal epithelium functions as a barrier to protect multicellular organisms from the outside world. It consists of epithelial cells closely connected by intercellular junctions, selective gates which control paracellular diffusion of solutes, ions and macromolecules across the epithelium and keep out pathogens. Rotavirus is one of the major ent...
Zuo, Jiakun Yin, Huifang Hu, Jiangang Miao, Jinfeng Chen, Zhaoguo Qi, Kezong Wang, Zhihao Gong, Jiansen Phouthapane, Vanhnaseng Jiang, Wei
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Published in
Veterinary Research
The function of Autoinducer-2 (AI-2) which acts as the signal molecule of LuxS-mediated quorum sensing, is regulated through the lsr operon (which includes eight genes: lsrK, lsrR, lsrA, lsrC, lsrD, lsrB, lsrF, and lsrG). However, the functions of the lsr operon remain unclear in avian pathogenic Escherichia coli (APEC), which causes severe respira...
Cheng, Guifeng Li, Xiaochun Qin, Fanglin Xu, Rong Zhang, Yuanyuan Liu, Jinming Gu, Shaopeng Jin, Yamei
Published in
Veterinary Research
Schistosomiasis is a globally important helminthic disease of humans and animals, and it is the second most common parasitic disease after malaria. Eggs produced by mature females are responsible for the disease’s occurrence and spread. Frzb2, a secreted frizzled-related protein, can inhibit Wnt signalling by competitive binding to the specific fri...
