Tyritzis, Stavros I Wilderäng, Ulrica Lantz, Αnna Wallerstedt Steineck, Gunnar Hugosson, Jonas Bjartell, Anders Stranne, Johan Haglind, Eva Wiklund, Nils Peter
Published in
Urologic oncology
Differences exist concerning when and how to perform lymph node dissection (LND) during radical prostatectomy due to lack of high-grade evidence to its safety and efficacy. We aimed to compare readmission rates between limited and extended LND during open radical prostatectomy (ORP) and robot-assisted radical prostatectomy (RARP). We conducted a pr...
Pooli, Aydin Salmasi, Amirali Johnson, David C Lenis, Andrew T Faiena, Izak Lebacle, Cedric Golla, Vishnukamal Drakaki, Alexandra Gollapudi, Kiran Blumberg, Jeremy
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Published in
Urologic oncology
Positive surgical margins (PSMs) are associated with treatment failure after radical prostatectomy (RP) for patients with prostate cancer (CaP). We investigated institutional variations in PSM after RP, as well as clinical and demographic factors predicting PSM. Patients undergoing RP for clinically localized CaP were identified in the National Can...
Schubert, Tina Renninger, Markus Schmid, Manuel Alexander Hassan, Fahmy Nabil Sokolakis, Ioannis Fahmy, Omar Hatzichristodoulou, Georgios Stenzl, Arnulf Gakis, Georgios
Published in
Urologic oncology
To assess whether the presence and location of tumor-associated immune cell infiltrates (TAIC) on histological slides obtained from cystectomy specimens impacts on oncological outcomes of patients with bladder cancer (BC). A total of 320 consecutive patients staged with cM0 bladder cancer underwent radical cystectomy (RC) between 2004 and 2013. The...
Hänze, Jörg Rexin, Peter Jakubowski, Peter Schreiber, Henner Heers, Hendrik Lingelbach, Susanne Kinscherf, Ralf Weihe, Eberhard Hofmann, Rainer Hegele, Axel
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Published in
Urologic oncology
Innervation of prostate cancer (CaP) tissue favors tumor progression and metastasis but the regulation of innervation in CaP is unclear. The oncogenic transcription factor ERG is commonly induced by a typical TMPRSS2-ERG (TE) gene fusion in CaP and may affect innervation. Here, we analyzed whether nerve density of CaP tissue is related to TE status...
Niziers, Vincent Boissier, Romain Borchiellini, Delphine Deville, Jean-Laurent Khoury, Cédric Durand, Matthieu Toledano, Harry Albert, Thomas Branger, Nicolas Bandelier, Quentin
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Published in
Urologic oncology
The role of 18F-fluorocholine positron emission tomography/computed tomography (18F-Choline PET/CT) in different clinical situations remains controversial and current practices are very heterogeneous. The aim of this study was to evaluate the "real-world" practice of 18F-Choline PET/CT in patients with prostate cancer and its potential impacts on t...
Grivas, Petros Bismar, Tarek A Alva, Aijai S Huang, Huei-Chung Liu, Yang Seiler, Roland Alimohamed, Nimira Cheng, Liang Hyndman, M Eric Dabbas, Bashar
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Published in
Urologic oncology
Neuroendocrine (NE)-like carcinoma is a newly recognized molecular subtype of conventional urothelial carcinoma of the bladder with transcriptomic profiles and clinical outcomes highly similar to histological NE carcinoma. The identification of NE-like tumors is challenging, as these tumors often appear histologically like urothelial carcinoma and ...
Zhai, Ting-Shuai Jin, Liang Hu, Lan-Ting Kadier, Aimaitiaji Zhou, Zhen Liu, Xiang Liu, Huan Li, Sheng Lu, Jing-Yi Yao, Xu-Dong
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Published in
Urologic oncology
To estimate the impact of peri-prostatic fat (PPF) measurements using preoperative magnetic resonance imaging on the prediction of prostate cancer (PCa) with transrectal ultrasound-guided biopsy. We performed a retrospective 2-center study on 660 consecutive patients receiving transrectal ultrasound-guided biopsy-biopsy from June 2016 to October 20...
Burgess, Earle F Livasy, Chad Trufan, Sally Hartman, Aaron Guerreri, Renato Naso, Caroline Clark, Peter E Grigg, Claud Symanowski, James Raghavan, Derek
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Published in
Urologic oncology
Overexpression of aurora kinase A (AURKA) confers a poor prognosis in patients with urothelial carcinoma of the bladder. The prognostic value of high aurora kinase B (AURKB) expression in local bladder cancer is not well defined, and whether the prognostic value of either AURKA or AURKB is affected by the use of chemotherapy is unknown. We sought t...
Owyong, Michael Koru-Sengul, Tulay Miao, Feng Razdan, Shirin Moore, Kevin J Alameddine, Mahmoud Punnen, Sanoj Parekh, Dipen J Ritch, Chad R Gonzalgo, Mark L
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Published in
Urologic oncology
We assessed the impact of open or minimally-invasive partial cystectomy on surgical margin status in a nationwide hospital-based cohort. Patients who underwent partial cystectomy from 2010 to 2014 were identified in the National Cancer Data Base. The primary outcome was surgical margin status. A multivariable logistic regression model was fitted to...
Shkolyar, Eugene Laurie, Mark A Mach, Kathleen E Trivedi, Dharati R Zlatev, Dimitar V Chang, Timothy C Metzner, Thomas J Leppert, John T Kao, Chia-Sui Liao, Joseph C
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Published in
Urologic oncology
Surgical management of penile cancer depends on accurate margin assessment and staging. Advanced optical imaging technologies may improve penile biopsy and organ-sparing treatment. We evaluated the feasibility of confocal laser endomicroscopy for intraoperative assessment of benign and malignant penile tissue. With institutional review board approv...
