Fujita, Naoki Hatakeyama, Shingo Okita, Kazutaka Momota, Masaki Narita, Takuma Tobisawa, Yuki Yoneyama, Tohru Yamamoto, Hayato Imai, Atsushi Ito, Hiroyuki
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Published in
Urologic oncology
To investigate the impact of chronic kidney disease (CKD) on oncological outcomes in patients with high-risk non-muscle invasive bladder cancer (NMIBC) who underwent adjuvant induction bacillus Calmette-Guérin (BCG) therapy after transurethral resection of bladder tumor (TURBT). We conducted a multi-institutional retrospective study assessing 209 p...
Bhambhvani, Hriday P Zamora, Alvaro Shkolyar, Eugene Prado, Kris Greenberg, Daniel R Kasman, Alex M Liao, Joseph Shah, Sumit Srinivas, Sandy Skinner, Eila C
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Published in
Urologic oncology
When exploring survival outcomes for patients with bladder cancer, most studies rely on conventional statistical methods such as proportional hazards models. Given the successful application of machine learning to handle big data in many disciplines outside of medicine, we sought to determine if machine learning could be used to improve our ability...
Kodama, Hirotake Hatakeyama, Shingo Momota, Masaki Togashi, Kyo Hamaya, Tomoko Hamano, Itsuto Fujita, Naoki Kojima, Yuta Okamoto, Teppei Yoneyama, Tohru
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Published in
Urologic oncology
To determine how frailty and comorbidities affect surgical contraindication in patients with localized prostate cancer (CaP). We evaluated the effects of frailty in 479 patients with localized CaP who were treated with robot-assisted radical prostatectomy (RARP), or radiotherapy (RT) eligible for surgery (RT-nonfrail), or those with RT ineligible f...
Murthy, Vedang Bakshi, Ganesh Manjali, Jifmi Jose Prakash, Gagan Pal, Mahendra Joshi, Amit Dholakia, Kunal Bhattacharjee, Atanu Talole, Sanjay Puppalwar, Abhinav
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Published in
Urologic oncology
We report the patterns of locoregional recurrence (LRR) in muscle invasive bladder cancer (MIBC), and propose a risk stratification to predict LRR for optimizing the indication for adjuvant radiotherapy. The study included patients of urothelial MIBC who underwent radical cystectomy with standard perioperative chemotherapy between 2013 and 2019. Re...
Stockert, Jennifer A Weil, Rachel Yadav, Kamlesh K Kyprianou, Natasha Tewari, Ashutosh K
Published in
Urologic oncology
Epitranscriptomic analysis has recently led to the profiling of modified nucleosides in cancer cell biological matrices, helping to elucidate their functional roles in cancer and reigniting interest in exploring their use as potential markers of cancer development and progression. Pseudouridine, one of the most well-known and the most abundant of t...
Kawada, Tomoyuki
Published in
Urologic oncology
Cakir, Omer Onur Castiglione, Fabio Tandogdu, Zafer Collins, Justin Alnajjar, Hussain M Akers, Clare Albersen, Maarten Alifrangis, Constantine Ayres, Benjamin Brouwer, Oscar
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Published in
Urologic oncology
To develop an international consensus on managing penile cancer patients during the COVID-19 acute waves. A major concern for patients with penile cancer during the coronavirus disease 2019 (COVID-19) pandemic is how the enforced safety measures will affect their disease management. Delays in diagnosis and treatment initiation may have an impact on...
Smelser, Woodson W Randall, Joseph Hogan Caldwell, Joshua Glavin, Katherine Lee, Eugene K Nangia, Ajay Holzbeierlein, Jeffrey M
Published in
Urologic oncology
Prior studies have demonstrated declines in androgen levels in men with cancer and patients undergoing anesthesia and surgery. In this study, we hypothesized that decreased serum androgen levels are prevalent in male patients undergoing radical cystectomy (RC) for bladder cancer and that it persists in the postoperative period. We characterized per...
Shukla, Kamla Kant Misra, Sanjeev Sankanagoudar, Shrimanjunath Sharma, Himanshu Choudhary, Gautam Ram Pareek, Puneet Vishnoi, Jeevan Ram Sharma, Praveen
Published in
Urologic oncology
Prostate cancer (CaP) is a leading cause of cancer deaths in the worldwide with broad range of clinical manifestations ranging from relatively indolent to aggressive metastasis. Altered expression of many circulating long non-coding RNAs (lncRNAs), known to have role in tumorigenesis and metastasis, have already been reported in CaP patients. These...
Oo, Htoo Zarni Seiler, Roland Black, Peter C Daugaard, Mads
Published in
Urologic oncology
Over the past decade, genomic and transcriptomic analyses have uncovered promising tumor antigens including immunotherapeutic targets in bladder cancer (BCa). Conventional tumor antigens are proteins expressed on the plasma membrane of tumor cells such as EGFR, FGFR3, and ERBB2 in BCa, which can be targeted by antibodies or similar epitope-specific...
