Aydemİr Çoban, Esra Tecİmel, Didem KaŞikci, Ezgi Bayrak, Ömer Faruk Şahİn, Fikrettin
Published in
Turkish journal of biology = Turk biyoloji dergisi
Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression...
Sari, Ceren SÜmer, Ceren Celep EyÜpoĞlu, Figen
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Turkish journal of biology = Turk biyoloji dergisi
Colorectal cancer is one of the most common types of cancer. Drug resistance and drug-induced damage of healthy tissues are major obstacles in cancer treatment. Therefore, to develop efficient anticancer therapy, it is necessary to find compounds that affect tumor cells, but do not exhibit toxicity to healthy cells. Caffeic acid phenethyl ester (CA...
Pehlİvan KarakaŞ, Fatma CoŞkun, Hamit SoytÜrk, Hayriye Bozat, Bihter Gökçe
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Turkish journal of biology = Turk biyoloji dergisi
Recent studies have indicated that polysaccharides, the main component of the Lycium barbarum L. fruit, have beneficial effects (e.g., anxiolytic, antioxidant, and neuroprotective) on humans and rodents. However, the effects of different dosages of such polysaccharides on ovariectomized rats and their underlying mechanisms in the brain have not bee...
TaŞli, Pakize Neslihan YalÇin Ülker, Gül Merve Cumbul, Alev Uslu, Ünal Yilmaz, Şahin Bozkurt, Batuhan Turhan Şahİn, Fikrettin
Published in
Turkish journal of biology = Turk biyoloji dergisi
Neogenesis of osseous and ligamentous interfacial structures is essential for the regeneration of large oral or craniofacial defects. However, current treatment strategies are inadequate in renewing supporting tissues of teeth after trauma, chronic infections or surgical resection. Combined use of 3D scaffolds with stem cells became a promising tre...
GenÇ, Rükan YakuboĞullari, Nilgün Nalbantsoy, Ayşe ÇÖven, Fethiye Bedİr, Erdal
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Turkish journal of biology = Turk biyoloji dergisi
Adjuvants are substances that increase the immune response to a given antigen. In the development of novel vaccine adjuvants/systems, saponins are one of the most attractive molecules due to their altered immunomodulatory activities. In this study, we tried to develop PEG (polyethylene glycol)/cholesterol-based lipid nanoparticles (LNPs) to deliver...
Şahİn, Günce Tellİ, Murat ÜnlÜ, Ercan Selçuk Pehlİvan KarakaŞ, Fatma
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Turkish journal of biology = Turk biyoloji dergisi
Physalis peruviana L. (Cape gooseberry) is a source for a variety of phytocompounds such as withanolides, withanone, withaferin A, and withanolide A. These withanolides are high-value drug candidates due to their various pharmacological properties. To meet the increasing demands for these compounds, plant cell technology offers a reliable alternati...
Nguyen, Thanh Thi Ngoc Tran, Minh Thi Hong Nguyen, Vy Thi Lan Nguyen, Uyen Doan Phuong Nguyen, Giang Dien Thanh Huynh, Luan Huu Nguyen, Hue Thi
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Turkish journal of biology = Turk biyoloji dergisi
MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant gro...
AydoĞan TÜrkoĞlu, Sümeyye Dayi, Gizem KÖÇkar, Feray
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Turkish journal of biology = Turk biyoloji dergisi
Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. PSMD4 overexpression has been observed in colon carcinoma, hepatocellular carcinoma, and breast cancer. In this work, we eluc...
Karakurt, Serdar AbuŞoĞlu, Gülsüm Arituluk, Zekiye Ceren
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Turkish journal of biology = Turk biyoloji dergisi
Resistance to therapeutic agents and the highly toxic side effects of synthetic drugs has spurred new research in the treatment of colon cancer, which has high morbidity and mortality ratios. This study aims to clarify the molecular mechanisms of the anticarcinogenic properties of methanol extract of Viburnum opulus L. (EVO)and its main active comp...
Ertosun, Mustafa Gökhan DİlmaÇ, Sayra Hapİl, Fatma Zehra TanriÖver, Gamze KÖksoy, Sadi ÖzeŞ, Osman Nidai
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Turkish journal of biology = Turk biyoloji dergisi
E2F1 becomes activated during the G1 phase of the cell cycle, and posttranslational modifications modulate its activity. Activation of G-protein coupled receptors (GPCR) by many ligands induces the activation of adenylate cyclases and the production of cAMP, which activates the PKA enzyme. Activated PKA elicits its biological effect by phosphorylat...
