Desai, Krisha Aiyappa, Radhika Prabhu, Jyothi S Nair, Madhumathy G Lawrence, Patrick Varun Korlimarla, Aruna Ce, Anupama Alexander, Annie Kaluve, Rohini S Manjunath, Suraj
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Published in
Tumor Biology
Despite an overall good prognosis, a significant proportion of patients with hormone receptor positive human epidermal growth factor receptor 2 negative breast cancers develop distant metastases. The metastatic potential of epithelial cells is known to be regulated by tumor-stromal interaction and mediated by epithelial-to-mesenchymal transition. H...
Wang, Xiao-xu Liu, Jue Tang, Yi-min Hong, Liang Zeng, Zhi Tan, Guang-hua
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Tumor Biology
MicroRNAs (miRNAs) are a type of small noncoding RNAs that often play important roles in carcinogenesis, but the carcinogenic mechanism of miRNAs is still unclear. This study will investigate the functions and the mechanism of miR-638 in osteosarcoma (OS). The expression of miR-638 in OS and the DNA copy number of miR-638 were detected by real-time...
Zhang, Yue Wang, Juan Wang, Wenxin Tian, Jie Yin, Kai Tang, Xinyi Ma, Jie Xu, Huaxi Wang, Shengjun
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Tumor Biology
It is widely acknowledged that a close relationship is between inflammation and colon cancer. Interleukin (IL)-17A and myeloid-derived suppressor cells (MDSCs) play an important role in the development of colitis-associated cancer (CAC). However, the precise changes of IL-17, MDSCs, and Th17 cells during the CAC progression have not been observed i...
Yan, Jin Dang, Yini Liu, Shiyu Zhang, Yifeng Zhang, Guoxin
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Tumor Biology
Altered expression of long noncoding RNAs (lncRNAs) has shown to associate with human cancer development and progression and drug resistance. LncRNA HOX antisense intergenic RNA (HOTAIR) regulates chromatin state and highly expressed in various human cancers. This study analyzed HOTAIR expression in gastric cancer cells and tissues and then assesse...
Li, Ya-Guang Liang, Nai-Xin Qin, Ying-Zhi Ma, Dong-Jie Huang, Chang-Jin Liu, Lei Li, Shan-Qing
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Tumor Biology
This study examined the effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity of human lung adenocarcinoma cell line A549 under hypoxic condition. Different CoCl2 concentrations were used to treat A549 cells and establish a CoCl2-induced hypoxic model of A549 cells. MTT and clone formation assays were use...
Hou, Lingmi Chen, Maoshan Zhao, Xiaobo Li, Jingdong Deng, Shishan Hu, Jiani Yang, Hongwei Jiang, Jun
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Tumor Biology
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is often associated with biologic behavior with frequent distant metastasis. FAT tumor suppressor homolog 4 (FAT4), a cadherin-related protein, is involved in a variety of biological processes as a tumor suppressor; however, the role of FAT4 in TNBC is still unclear...
Sun, Fang Xu, Xia Wang, Xiaohong Zhang, Bei
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Tumor Biology
Autophagy is an evolutionarily conserved lysosomal catabolic process used as an internal engine in response to nutrient starvation or metabolic stress. A number of protein complexes and an intricate network of stress signaling cascades impinge on the regulation of autophagy; the mammalian target of rapamycin serves as a canonical player. Ca2+, as a...
Zhang, Cheng Min, Li Liu, Jiafei Tian, Wei Han, Yong Qu, Like Shou, Chengchao
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Tumor Biology
The two major histological types of gastric cancer, intestinal and diffuse subtypes, have distinct epidemiological and pathophysiological features and were also suggested to be of diverse clinical outcomes. Although the gene expression spectrum of gastric cancer subtypes has been reported by previous studies, its linkage with gastric cancer clinica...
Lin, Zhipeng Hu, Baoying Ni, Wenkai Mao, Xiaofei Zhou, Huiling Lv, Jiale Yin, Bihui Shen, Zhongyi Wu, Miaomiao Ding, Wensen
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Tumor Biology
BCCIP was originally identified as a BRCA2- and CDKN1A- (Cip1/waf1/p21) interacting protein, also known as BCCIP. It has been reported to express in various types of cancers, including colorectal cancer (CRC), astrocytic brain tumors, and glioblastomas. However, the relationship between BCCIP expression and clinicopathological features of hepatocel...
Safaei, Hamid Reza Rostamzadeh, Ayoob Rahmani, Omid Mohammadi, Mohsen Ghaderi, Omar Yahaghi, Hamid Ahmadi, Koroosh
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Tumor Biology