Patel, Amrish Sims, Erika Blacklock, Jeanette Birt, Linda Bion, Veronica Clark, Allan Griffiths, Alys Guillard, Cecile Hammond, Amber Holland, Richard
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Trials
The care home staff influenza vaccination rate in England is significantly lower than the 75% World Health Organisation recommendation. This represents a substantial potential for resident harm. Barriers to staff vaccination stem from individual and organisational levels. Existing interventions address some but not all barriers and are not underpin...
Carranza, Christian L Ballegaard, Martin Werner, Mads U Hasbak, Philip Kjaer, Andreas Kofoed, Klaus Olsen, Markus Harboe Gluud, Christian Jakobsen, Janus Christian
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Trials
Coronary artery bypass grafting can be conducted using the radial artery as a bypass graft. However, it remains unclear which harvesting method is superior, i.e. endoscopic or open radial artery, and which site for proximal anastomosis of the radial artery has the greatest benefits? The NEO Trial is a single site randomised clinical trial with a 2 ...
Nägele, Felix Pölzl, Leo Graber, Michael Hirsch, Jakob Mayr, Agnes Pamminger, Mathias Troger, Felix Theurl, Markus Schreinlechner, Michael Sappler, Nikolay
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Trials
Coronary artery disease (CAD) remains a severe socio-economic burden in the Western world. Coronary obstruction and subsequent myocardial ischemia result in the progressive replacement of contractile myocardium with dysfunctional, fibrotic scar tissue. Post-infarctional remodelling is causal for the concomitant decline of left-ventricular function ...
Thompson, Wendy Teoh, Leanne Pulcini, Céline Williams, David Pitkeathley, Carole Carter, Vanessa Sanderson, Susie Torres, Glauco Walsh, Tanya
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Trials
BackgroundAntimicrobial resistance is both a global public health and patient safety problem driven by overprescribing of antibiotic and other antimicrobial drugs. To conserve the effectiveness of antibiotics for future generations, antibiotic stewardship approaches to using them only where appropriate and necessary are advocated. Dentistry account...
Armitage, Samantha Rapley, Tim Pennington, Lindsay McAnuff, Jennifer McColl, Elaine Duff, Catherine Brooks, Rob Kolehmainen, Niina
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Trials
Randomised controlled trials of non-pharmacological interventions in children's therapy are rare. This is, in part, due to the challenges of the acceptability of common trial designs to therapists and service users. This study investigated the acceptability of participation in cluster randomised controlled trials to therapists and service users. A ...
Mousavi, Seyed Mohammad Ejtahed, Hanieh-Sadat Malmir, Hanieh Siadat, Seyed Davar Hasani-Ranjbar, Shirin Larijani, Bagher Esmaillzadeh, Ahmad
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Trials
Metabolic syndrome (MetS) is a group of risk factors that increase the risk of death and a variety of chronic diseases. Recent studies have indicated that the imbalance of gut microbiota might contribute to development and progression of metabolic syndrome. Carbohydrate restriction in the diet has been proven to be one of the most effective methods...
A'zim, A'ishah Zafirah Abdul Zaid, Zalina Abu Yusof, Barakatun Nisak Mohd Jabar, Mohd Faisal Shahar, Aainaa Syarfa Mohd
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Trials
Perioperative malnutrition is common in patients undergoing gastrointestinal-oncology surgery and is associated with longer hospital stays, increased postoperative complications, poorer quality of life, and lower survival rates. Current practice emphasizes the role of early perioperative nutrition therapy as an early intervention to combat the post...
MeshkatAlsadat, Mehrnoush Hassani, Ali Bitaraf, Tahereh Salmasi, Salar Chaychi
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Trials
Dental implant therapy requires the preservation of peri-implant tissue in the cosmetic zone. Various surgical procedures have been presented, including ridge preservation, flapless method, and quick provisionalization. The goal of this research was to assess the buccal bone dimensional changes following immediate flapless implant implantation in t...
Shepherd, Victoria Wood, Fiona Gillies, Katie Martin, Adam O'Connell, Abby Hood, Kerenza
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Trials
Randomised trials play a vital role in underpinning evidence-based care. However, trials involving adults with impaired capacity to consent raise a number of ethical and methodological challenges, leading to the frequent exclusion of this group from trials. This includes challenges around involving family members as alternative 'proxy' decision-mak...
Krištof Mirt, Pika Strojnik, Vojko Kavčič, Gregor Trebše, Rihard
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Trials
Total hip arthroplasty (THA) is very effective in alleviating pain, but functional deficits persist up to a year following surgery. Regardless of standard physiotherapy programs, significant additional muscular atrophy and weakness occur. Deficits in strength have serious adverse consequences for these patients with respect to physical function, th...
