Dioh, W. Chabane, M. Tourette, C. Azbekyan, A. Morelot-Panzini, C. Hajjar, L. A. Lins, M. Nair, G. B. Whitehouse, T. Mariani, J.
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Published in
Trials
ObjectivesAs of December, 1st, 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, resulted in more than 1 472 917 deaths worldwide and death toll is still increasing exponentially. Many COVID-19 infected people are asymptomatic or experience moderate symptoms and recover without medical intervention. However, older people and those wit...
Aflaki, Mona Flannery, Alexandria Ferreira, João Pedro Cheng, Matthew Pellan Kronfli, Nadine Marelli, Ariane Zannad, Faiez Brophy, James Afillalo, Jon Huynh, Thao
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Published in
Trials
ObjectivesThe aim of the RAAS-COVID-19 randomized control trial is to evaluate whether an upfront strategy of temporary discontinuation of renin angiotensin aldosterone system (RAAS) inhibition versus continuation of RAAS inhibition among patients admitted with established COVID-19 infection has an impact on short term clinical and biomarker outcom...
Xue, Xin Jin, Xue-Ming Luo, Kai-Liang Liu, Xin-Hao Zhang, Li Hu, Jun
Published in
Trials
BackgroundStatistics show that every year, 5.4 million people in the world suffer a stroke. Post-stroke cognitive impairment (PSCI) is one of the most common complications after stroke with a rate of 75%, which leads to decreased functions for independent living and reduced quality of life (QOL). Exercise training has been reported to be useful to ...
Krämer, Rico Köhler, Stephan
Published in
Trials
BackgroundPatients with mild to moderate depressive symptoms can have limited access to regular treatment; to ensure appropriate care, low-threshold treatment is needed. Effective online interventions could increase the supply of low-threshold treatment. Further research is needed to evaluate the effectiveness of online interventions. This study ai...
Jiang, Xiao-juan Li, Zi Li, Qi Zhang, Hai-yan Tang, Xiao-hong Zhu, Tao
Published in
Trials
BackgroundPrevious study indicated that transversus abdominis plane (TAP) block could be the principal anesthetic technique for peritoneal dialysis catheter (PDC) implantations. However, a TAP block could not provide an optimal anesthetic effect on catheter exit site during PDC implantation. We hypothesized that single-injection ultrasound-guided t...
Garcia, Patricia J. Mundaca, Hansel Ugarte-Gil, Cesar Leon, Patricia Malaga, German Chaccour, Carlos Carcamo, Cesar P.
Published in
Trials
ObjectivesThe primary objective is to determine the effect of a daily dose of ivermectin administered in three consecutive days to non-severe COVID-19 patients with no more than 96 hours of symptoms, on the detection of SARS-CoV-2 RNA by PCR from nasopharyngeal swabs at day seven post-treatment initiation.The secondary objectives are: To assess the...
Horwood, Jeremy Chalder, Melanie Ainsworth, Ben Denison-Day, James de Vocht, Frank Elwenspoek, Martha M. C. Craggs, Pippa Denholm, Rachel Sterne, Jonathan Rice, Cathy
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Published in
Trials
ObjectivesTo examine the effectiveness of randomising dissemination of the Germ Defence behaviour change website via GP practices across England UK.Trial designA two-arm (1:1 ratio) cluster randomised controlled trial implementing Germ Defence via GP practices compared with usual care.ParticipantsSetting: All Primary care GP practices in England. P...
Tebartz van Elst, Ludger Fangmeier, Thomas Schaller, Ulrich Max Hennig, Oliver Kieser, Meinhard Koelkebeck, Katja Kuepper, Charlotte Roessner, Veit Wildgruber, Dirk Dziobek, Isabel
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Published in
Trials
BackgroundAutism spectrum disorder (ASD) is a chronic neurodevelopmental condition with a prevalence rate above 1%, characterized by deficits in social communication and interaction; restrictive, repetitive patterns of behavior, interests, or activities; and a preference for sameness and routines. The majority of adult ASD patients suffer from como...
Unger, Joseph M. Xiao, Hong
Published in
Trials
BackgroundThe COVID-19 pandemic has caused severe disruptions in care for many patients. A key question is whether the landscape of clinical research has also changed.MethodsIn a retrospective cohort study, we examined the association of the COVID-19 outbreak with new clinical trial activations. Trial data for all interventional and observational o...
Ye, Xin Zhu, Dawei Chen, Siyuan Shi, Xuefeng Gong, Rui Wang, Juncheng Zuo, Huibin Zhang, Mei He, Ping
Published in
Trials
BackgroundHearing loss is quite prevalent and can be related to people’s quality of life. To our knowledge, there are limited studies assessing the efficacy of hearing interventions on quality of life in adults. Therefore, we aim to conduct a randomized controlled trial (RCT) to determine the impact and cost-effectiveness of community-based hearing...
