Zhu, Zhaohua Yu, Qinghong Leng, Xiaomei Han, Weiyu Li, Zhanguo Huang, Cibo Gu, Jieruo Zhao, Yi Wang, Kang Li, Tianwang
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Trials
BackgroundOsteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effusion-synovitis and pain in symptomatic patients with mid- to ...
Donoghue, Kim Rose, Abigail Coulton, Simon Coleman, Rachel Milward, Joanna Philips, Thomas Drummond, Colin Little, Hilary
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Trials
BackgroundAlcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol withdrawal are associated with cognitive deficits and symptoms of depression. Current treatments are only successful for a small proportion of people and do not target cognitive deficits and symptoms of depression ex...
Caballero Bermejo, Antonio F. Ruiz-Antorán, Belén Fernández Cruz, Ana Diago Sempere, Elena Callejas Díaz, Alejandro Múñez Rubio, Elena Avendaño-Solá, Cristina Ramos Martínez, Antonio Sancho López, Aránzazu
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Trials
ObjectivesIn some patients, acute, life-threatening respiratory injury produced by viruses such as SARS-CoV and other viral pneumonia are associated with an over-exuberant cytokine release. Elevated levels of blood IL-6 had been identified as a one of the risk factors associated with severe COVID-19 disease.Anti-IL6 inhibitors are among the therape...
Safa, Omid Hassani-Azad, Mehdi Farashahinejad, Mehdi Davoodian, Parivash Dadvand, Habib Hassanipour, Soheil Fathalipour, Mohammad
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Trials
ObjectivesWe investigate the effects of Licorice (Glycyrrhiza glabra L.) root extract, an anti-inflammatory natural medicine, compared to the usual therapeutic regimen on clinical symptoms and laboratory signs in patients with confirmed COVID-19 that are moderately ill.Trial designThis is a single-center, open-label, randomized, clinical trial with...
Lundqvist, Stefan Börjesson, Mats Cider, Åsa Hagberg, Lars Ottehall, Camilla Bylin Sjöström, Johan Larsson, Maria E. H.
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Trials
BackgroundPhysical activity (PA) can be used to prevent and treat diseases. In Sweden, licensed healthcare professionals use PA on prescription (PAP) to support patients to increase their PA level. The aim of this randomized controlled trial was to evaluate a 2-year intervention of two different strategies of PAP treatment for patients with insuffi...
Gothe, Neha P. Erlenbach, Emily E. Streeter, Samuel L. Lehovec, Linda
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Trials
BackgroundCancer survivors experience compromised quality of life due to impaired cognitive function as a result of cancer diagnosis and treatment. Although exercise has proven to be effective in improving cognitive function across the lifespan, interventions comprehensively testing the effectiveness for cancer survivors are limited. The STAY Fit T...
Tegner, Heidi Esbensen, Bente Appel Henriksen, Marius Bech-Azeddine, Rachid Lundberg, Mari Nielsen, Louise Rolving, Nanna
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Trials
BackgroundPatients with chronic low back pain undergoing lumbar spinal fusion (LSF) are physically inactive and thereby at risk of poor health. Barriers to being physically active need to be acknowledged in post-surgical rehabilitation. The primary objective of this randomized controlled trial (RCT) is to examine the effect of an early active inter...
Bjørkedal, Siv Therese Bogevik Bejerholm, Ulrika Eplov, Lene Falgaard Møller, Tom
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Trials
BackgroundEngagement in activities meaningful to the individual may support the process of recovery in those with mental illness. Persons with psychiatric disabilities may reduce their engagement in meaningful activities to various degrees with possible fluctuations over time. We hypothesized that activity engagement can be altered when opportuniti...
Gavin, Nicole C. Kleidon, Tricia M. Larsen, Emily O’Brien, Catherine Ullman, Amanda Northfield, Sarah Mihala, Gabor Runnegar, Naomi Marsh, Nicole Rickard, Claire M.
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Trials
BackgroundTo evaluate the feasibility of an efficacy trial comparing a hydrophobic polyurethane peripherally inserted central catheter (PICC) with a standard polyurethane PICC.MethodsThis pilot randomised controlled trial (RCT) was conducted between May 2017 and February 2018. Adult participants (n = 111) were assigned to hydrophobic polyurethane P...
Yue, Hongyu Zhou, Shuang Wu, Huangan Yin, Xuan Li, Shanshan Liang, Tingting Li, Yan Fang, Zhihong Zhang, Xufeng Wang, Linglin
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Trials
BackgroundCancer-related insomnia (CRI) is one of the most prevalent complaints among cancer survivors and severely impairs patients’ quality of life. As a popular non-pharmacological alternative treatment, acupuncture provides a good clinical curative effect on insomnia. The aim of this trial is to evaluate efficacy and safety of electro-acupunctu...
