Couret, Chloé Poinas, Alexandra Volteau, Christelle Riche, Valery-Pierre Le Lez, Marie-Laure Errera, Marie-Hélène Creuzot-Garcher, Catherine Baillif, Stéphanie Kodjikian, Laurent Ivan, Catherine
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Trials
BackgroundWhether they are injected peri- or intraocularly, corticosteroids are still essential tools in the therapeutic arsenal for treating inflammatory macular oedema. A few years ago, however, only triamcinolone acetonide was available to ophthalmologists. While this compound was initially developed for rheumatological or dermatological use, it...
Lühnen, Julia Berger-Höger, Birte Haastert, Burkhard Hinneburg, Jana Kasper, Jürgen Steckelberg, Anke
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Trials
BackgroundThe evidence-based guideline entitled guideline evidence-based health information emerged from the German Network for Evidence-based Medicine (DNEbM) and was published in February 2017. The guideline addresses providers of health information and its goal is to improve the quality of health information. In addition, we explored the compete...
Buljan, Ivan Tokalić, Ružica Roguljić, Marija Zakarija-Grković, Irena Vrdoljak, Davorka Milić, Petra Puljak, Livia Marušić, Ana
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Trials
BackgroundCochrane, an organization dedicated to the production and dissemination of high-quality evidence on health, endeavors to reach consumers by developing appropriate summary formats of its systematic reviews. However, the optimal type of presentation of evidence to consumers is still unknown.ObjectiveThe aim of this study was to investigate ...
Wason, James McMenamin, Martina Dodd, Susanna
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Trials
BackgroundClinical trials and other studies commonly assess the effectiveness of an intervention through the use of responder-based endpoints. These classify patients based on whether they meet a number of criteria which often involve continuous variables categorised as being above or below a threshold. The proportion of patients who are responders...
Feeney, Eoin Wallace, Deborah Cotter, Aoife Tinago, Willard McCarthy, Cormac Keane, David Hussain, Rabia Alvarez Barco, Elena Doran, Peter Mallon, Patrick
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Trials
Liu, Hongji Li, Xiang Zhang, Zongduan Zeng, Jieping Dai, Yan Wang, Chao Xie, Zhao Cheng, Lin Cui, Linru
Published in
Trials
BackgroundAs an irreversible, intractable disease with vision loss, glaucoma leads to permanent and progressive damage of visual function. Lowering high intraocular pressure (HIOP) is the first choice for treating glaucoma; however, the control of HIOP is not enough to prevent progressive vison loss. Currently, the therapies to treat glaucoma with ...
Collins, Michael G. Fahim, Magid A. Pascoe, Elaine M. Dansie, Kathryn B. Hawley, Carmel M. Clayton, Philip A. Howard, Kirsten Johnson, David W. McArthur, Colin J. McConnochie, Rachael C.
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Published in
Trials
BackgroundDelayed graft function, the requirement for dialysis due to poor kidney function post-transplant, is a frequent complication of deceased donor kidney transplantation and is associated with inferior outcomes and higher costs. Intravenous fluids given during and after transplantation may affect the risk of poor kidney function after transpl...
Anders, Katherine L. Indriani, Citra Ahmad, Riris Andono Tantowijoyo, Warsito Arguni, Eggi Andari, Bekti Jewell, Nicholas P. Dufault, Suzanne M. Ryan, Peter A. Tanamas, Stephanie K.
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Published in
Trials
BackgroundThe AWED (Applying Wolbachia to Eliminate Dengue) trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Yogyakarta, Indonesia, with the aim of measuring the efficacy of Wolbachia-infected Aedes aegypti deployments in reducing dengue incidence in an endemic setting. Enrolment began in January 20...
Rades, Dirk Narvaez, Carlos Andres Doemer, Claudia Janssen, Stefan Olbrich, Denise Tvilsted, Soeren Conde-Moreno, Antonio J. Cacicedo, Jon
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Trials
BackgroundRadiotherapy of head-and-neck cancer can be associated with significant toxicities including dermatitis and oral mucositis. Severe toxicities may require interruptions of the radiation treatment associated with impairment of the patients’ prognoses. This study will investigate whether the addition of a reminder app to standard care can re...
Tang, Shuk Kwan Tse, Mimi Mun Yee Leung, Sau Fong Fotis, Theofanis
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Trials
BackgroundChronic pain is highly prevalent in the working population. People tend to attempt self-initiated treatments to manage their pain. The self-efficacy of behavioural change is a suitable model for guiding the development of an electronic pain management programme (ePain). The aim in this study is to develop ePain and to evaluate its effecti...
