Thompson, Wendy Teoh, Leanne Pulcini, Céline Williams, David Pitkeathley, Carole Carter, Vanessa Sanderson, Susie Torres, Glauco Walsh, Tanya
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Trials
BackgroundAntimicrobial resistance is both a global public health and patient safety problem driven by overprescribing of antibiotic and other antimicrobial drugs. To conserve the effectiveness of antibiotics for future generations, antibiotic stewardship approaches to using them only where appropriate and necessary are advocated. Dentistry account...
Shang, Ya-Xi Dong, Xia Xie, Zhi-Min Li, Xiao-Peng Wang, Xin-Chang Huang, Ji-Yong Wei, Shu-Feng Liu, Yuan Liu, Jian-Ping
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Acute gouty arthritis (AGA) is an inflammatory arthritis clinically characterized by severe pain, swelling, and restricted movement of joints, which may cause physical disability and decrease quality of life. The use of recommended first-line treatment agents for AGA may be limited by adverse events. There has been a traditional use of alternative ...
Powell, Alison Hoare, Sarah Modi, Rakesh Williams, Kate Dymond, Andrew Chapman, Cheryl Griffin, Simon Mant, Jonathan Burt, Jenni
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Trials
Qualitative research can enhance the design, conduct and interpretation of trials. Despite this, few trials incorporate qualitative methods, and those that do may not realise their full potential. In this commentary, we highlight how qualitative research can contribute to the design, conduct and day-to-day running of a trial, outlining the working ...
Pearse, India Corley, Amanda Larsen, Emily N Rickard, Claire M Ware, Robert S Campbell, Jill Coyer, Fiona Alexandrou, Evan O'Brien, Catherine Marsh, Nicole
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Trials
Central venous access devices (CVADs) can have high rates of failure due to dressing-related complications. CVADs placed in the internal jugular vein are at particular risk of dressing failure-related complications, including catheter-associated bloodstream infection and medical adhesive-related skin injury. Application of Mastisol liquid adhesive ...
Qi, Yuhan Wang, Jiarong Zhao, Jichun Huang, Bing Xiong, Fei Du, Xiaojiong Chen, Xiyang Guo, Qiang Wang, Tiehao Yuan, Ding
...
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Trials
Covered stent has become one of the mainstream therapies for aortoiliac obstructive disease (AIOD), with a higher patency rate than bare metal stent. Covered balloon-expandable (CBE) stent can be placed more accurately with higher a radial support force, while covered self-expanding (CSE) stent has greater elasticity and higher trackability. Howeve...
Knutson, Jayme S Friedl, Amy S Hansen, Kristine M Harley, Mary Y Barrett, A M Raghavan, Preeti Plow, Ela B Gunzler, Douglas D Chae, John
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Trials
Multi-site studies in stroke rehabilitation are important for determining whether a technology and/or treatment can be successfully administered by sites other than the originating site and with similar positive outcomes. This study is the first multi-site clinical trial of a novel intervention for post-stroke upper limb rehabilitation called contr...
Wall, Kristin M Ingabire, Rosine Mazzei, Amelia Umuhoza, Claudine Parker, Rachel Tichacek, Amanda Nizam, Azhar Sales, Jessica M Haddad, Lisa B Corso, Phaedra
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Trials
Though the Rwandan Ministry of Health (MOH) prioritizes the scale-up of postpartum family planning (PPFP) programs, uptake and sustainability of PPFP services in Rwanda are low. Furthermore, highly effective long-acting reversible contraceptive method use (LARC), key in effective PPFP programs, is specifically low in Rwanda. We previously pilot tes...
Barco, Stefano Sebastian, Tim Voci, Davide Engelberger, Rolf Peter Grigorean, Alexandru Holy, Erik Leeger, Claudia Münger, Mario Périard, Daniel Probst, Eliane
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Trials
Peripheral arterial disease is a progressive atherosclerotic disease with symptoms ranging from an intermittent claudication to acute critical limb ischemia and amputations. Drug-coated balloons and stents were developed to prevent neo-intimal proliferation and restenosis after percutaneous transluminal angioplasty. Randomized controlled trials sho...
Rodriguez, Robert M O'Laughlin, Kelli Eucker, Stephanie A Chang, Anna Marie Rising, Kristin L Nichol, Graham Pauley, Alena Kanzaria, Hemal Gentsch, Alexzandra T Li, Cindy
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Trials
We conducted in-depth interviews to characterize reasons for COVID-19 vaccine hesitancy in emergency department (ED) patients and developed messaging platforms that may address their concerns. In this trial, we seek to determine whether provision of these COVID-19 vaccine messaging platforms in EDs will be associated with greater COVID-19 vaccine a...
Li, Ruiyang Sun, Pingping Zhan, Yu Xie, Xuetao Yan, Weibing Luo, Congfeng
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Trials
Knee osteoarthritis (OA) is a leading cause of global disability. According to current guidelines, exercise is the most recommended and important non-surgical treatment for knee OA. However, the best type of exercise for this condition remains unclear. Evidence has shown that traditional Chinese exercises may be more effective. Therefore, the curre...
