Iannino, Nadia Fischer, Kady Friedrich, Matthias Hafyane, Tarik Mongeon, Francois-Pierre White, Michel
Published in
Transplantation
Coronary vascular function is related to adverse outcomes following cardiac transplantation (CTx) in patients with or without cardiac allograft vasculopathy (CAV). The noninvasive assessment of the myocardial vascular response using oxygenation-sensitive cardiac magnetic resonance (OS-CMR has not been investigated in stable long-term CTx recipients...
Cao, Yue Alexander, Stephen I Chapman, Jeremy R Craig, Jonathan C Wong, Germaine Yang, Jean Y H
Published in
Transplantation
Noninvasive biomarkers may predict adverse events such as acute rejection after kidney transplantation and may be preferable to existing methods because of superior accuracy and convenience. It is uncertain how these biomarkers, often derived from a single study, perform across different cohorts of recipients. Using a cross-validation framework tha...
Filippone, Edward John Farber, John L
Published in
Transplantation
Defined as histologic evidence of rejection on a protocol biopsy in the absence of kidney dysfunction, subclinical rejection has garnered attention since the 1990s. The major focus of much of this research, however, has been subclinical T cell-mediated rejection (TCMR). Herein, we review the literature on subclinical antibody-mediated rejection (AM...
Xiao, Hanyu Gao, Fang Pang, Qidan Xia, Qiuxiang Zeng, Xianpeng Peng, Jingtao Fan, Lei Liu, Jiali Wang, Zhendi Li, Heng
...
Published in
Transplantation
Donor-derived cell-free DNA (dd-cfDNA) is a potential noninvasive molecular marker of graft rejection after kidney transplant, whose diagnostic accuracy remains controversial. We performed a systematic review and metaanalysis to evaluate the diagnostic accuracy of dd-cfDNA. Relevant literature was searched from online databases, and the data on the...
Kataria, Ashish Kumar, Dhiren Gupta, Gaurav
Published in
Transplantation
The last few years have seen an explosion in clinical research focusing on the use of donor-derived cell-free DNA (dd-cfDNA) in solid-organ transplants (SOT). Although most of the literature published so far focuses on kidney transplants, there are several recent as well as ongoing research studies on heart, lung, pancreas, and liver transplants. T...
Anggelia, Madonna Rica Cheng, Hui-Yun Chuang, Wen-Yu Hsieh, Yun-Huan Wang, Aline Yen Ling Lin, Chih-Hung Wei, Fu-Chan Brandacher, Gerald Lin, Cheng-Hung
Published in
Transplantation
The role of regulatory T cells (Treg) in tolerance induction of vascularized composite allotransplantation (VCA) remains unclear. This study was designed to examine characteristics of Treg after VCA and their capacity to rescue allografts from rejection. Osteomyocutaneous allografts were transplanted from Balb/c to C57BL/6 mice. All mice received c...
Bikhet, Mohamed Iwase, Hayato Yamamoto, Takayuki Jagdale, Abhijit Foote, Jeremy B Ezzelarab, Mohamed Anderson, Douglas J Locke, Jayme E Eckhoff, Devin E Hara, Hidetaka
...
Published in
Transplantation
We discuss what therapeutic regimen might be acceptable/successful in the first clinical trial of genetically engineered pig kidney or heart transplantation. As regimens based on a calcineurin inhibitor or CTLA4-Ig have proved unsuccessful, the regimen we administer to baboons is based on induction therapy with antithymocyte globulin, an anti-CD20 ...
Melanson, Taylor A Mersha, Karie Patzer, Rachel E George, Roshan P
Published in
Transplantation
Patients' loss to follow-up (LFU) has significant impacts on outcomes and is a barrier to improving care, especially in adolescent and young adult (AYA) renal transplant recipients. There is limited information regarding the relationship between transfer of care from pediatric to adult transplant centers, age, and LFU among AYA renal transplant rec...
Itabashi, Yoshihiro Ravichandran, Ranjithkumar Bansal, Sandhya Bharat, Ankit Hachem, Ramsey Bremner, Ross Smith, Michael Mohanakumar, T
Published in
Transplantation
Chronic lung allograft dysfunction (CLAD), is a major hurdle for long-term lung allograft survival after lung transplant and roughly 50% of lung transplant recipients (LTxRs) develop CLAD within 5 years. The mechanisms of CLAD development remain unknown. Donor-specific immune responses to HLA and lung self-antigens (SAgs) are vital to the pathogene...
Serrano, Oscar K Peterson, Kent J Vock, David M Berglund, Danielle Kandaswamy, Raja Lake, John R Pruett, Timothy L Chinnakotla, Srinath
Published in
Transplantation
Bariatric surgery (BS) may be associated with significant malabsorption and nutritional deficiencies. Between March 1987 and January 2017, we performed 922 liver transplants (LT) at our institution; 33 had antecedent BS. We matched the BS cohort to LT recipients without BS (1:3 matching) based on exact matching for gender and cancer and inverse var...
