ATMPs: New Challenge for Transfusion Services
Published in Transfusion Medicine and Hemotherapy
ATMPs: New Challenge for Transfusion Services
Advanced Therapy Medicinal Products and the Changing Role of Academia
Published in Transfusion Medicine and Hemotherapy
Academic institutions coin the ATMP landscape but do not possess an industry-like capacity to vigorously pursue the full developmental pathway to marketing authorization. At the same time, industry has fostered clinical trials with ATMPs, brought the first products to marketing authorization, and defined novel modes of interaction with academia. A ...
Safety of Intraoperative Cell Salvage in Cancer Surgery: An Updated Meta-Analysis of the Current Literature
Published in Transfusion Medicine and Hemotherapy
Background: Allogeneic blood transfusions in oncologic surgery are associated with increased recurrence and mortality. Adverse effects on outcome could be reduced or avoided by using intraoperative autologous blood cell salvage (IOCS). However, there are concerns regarding the safety of the autologous IOCS blood. Previous meta-analyses from 2012 an...
Platelet-Rich Plasma in Plastic Surgery: A Systematic Review
Published in Transfusion Medicine and Hemotherapy
Introduction: Platelet-rich plasma (PRP) is gaining popularity and is applied in a variety of clinical settings. This review aims to present and evaluate available evidence regarding the use of PRP in various applications in plastic surgery. Methods: PubMed, Web of Science, Medline, and Embase were searched using predefined MeSH terms to identify s...
Efficacy and Safety of Blood Derivative Therapy for Patients with COVID-19: A Systematic Review and Meta-Analysis
Published in Transfusion Medicine and Hemotherapy
Background The outbreak of COVID-19 has resulted in more than 200 million infections and 4 million deaths. The blood derivative therapy represented by intravenous immunoglobulin (IVIG) and convalescent plasma (CP) therapy may be the promising therapeutics for COVID-19. Methods A systematic article search was performed for eligible studies published...
Severe Acute Respiratory Syndrome Coronavirus 2 and Blood Safety: An Updated Review
Published in Transfusion Medicine and Hemotherapy
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human coronavirus first identified in late 2019 and subsequently declared a worldwide pandemic in March 2020. In this review, we provide an overview of the implications of SARS-CoV-2 for blood safety and sufficiency. Summary Approximately one-third of SARS-CoV-2 infe...
Noninferior Red Cell Concentrate Quality after Repeated Air Rescue Mission Transport for Prehospital Transfusion
Published in Transfusion Medicine and Hemotherapy
Background: Transfusion of red cell concentrates (RCCs) is an integral therapy after severe hemorrhage or trauma. Prehospital transfusion offers an immediate intervention in emergency cases. Air ambulance-based prehospital transfusion, already used in different countries, is currently established in Germany. Limited information is available for reg...
XK-Associated McLeod Syndrome: Nonhematological Manifestations and Relation to VPS13A Disease
Published in Transfusion Medicine and Hemotherapy
Background: McLeod syndrome (MLS) is an X-linked multisystemic progressive disorder caused by loss of function mutations in the XK gene. The rare blood group phenotype of MLS patients with absent Kx antigen requires the support of specialized transfusion institutions because of the risk of transfusion complications. Acanthocytosis of red blood cell...
Association of Blood Group Antigen CD59 with Disease
Published in Transfusion Medicine and Hemotherapy
In 2014, the membrane-bound protein CD59 became a blood group antigen. CD59 has been known for decades as an inhibitor of the complement system, located on erythrocytes and on many other cell types. In paroxysmal nocturnal haemoglobinuria (PNH), a stem cell clone with acquired deficiency to express GPI-anchored molecules, including the complement i...
Blood Groups and Their Correlation with Hereditary Disease
Published in Transfusion Medicine and Hemotherapy
