Gali, Sreevarsha Sharma, Swati Kundu, Amit Lee, Eunah Han, Joo Hee Shin, Joo Kyung Choi, Ji Soo Kyung, So Young Kim, Jae-Sung Kim, Hyung Sik
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Toxicology mechanisms and methods
Cadmium (Cd) accumulates in the body through contaminated foods or water and causes pathological damage to the liver via oxidative stress and inflammatory reactions. This study was conducted to explore the effects of dendropanoxide (DPx) on Cd-induced hepatotoxicity in rats. Sprague-Dawley (SD) rats were injected with CdCl2 (7 mg/kg body weight) in...
Bhatt, Laxit K Shah, Chitrang R Patel, Rajesh J Patel, Shital D Patel, Sudhir R Patel, Vipul A Patel, Jitendra H Dwivedi, Pankaj Shah, Niraj A Sundar, Rajesh S
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Toxicology mechanisms and methods
Rhesus monkeys are a non-rodent species employed in the preclinical safety evaluation of pharmaceuticals and biologics. These nonhuman primate species have been increasingly used in biomedical research because of the similarity in their ionic mechanisms of repolarization with humans. Heart rate and QT interval are two primary endpoints in determini...
Ibrahim Fouad, Ghadha Mabrouk, Mostafa El-Sayed, Sara A M Rizk, Maha Z Beherei, Hanan H
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Toxicology mechanisms and methods
Cuprizone (CUP) induces neurotoxicity and demyelination in animal models by provoking the activation of glial cells and the generation of reactive oxygen species (ROS). Sulforaphane (SF) is a phytochemical that exhibits a neuroprotective potential. In this study, we investigated the neurotherapeutic and pro-remyelinating activities of SF and SF-loa...
Elsheikh, Arwa A Alnasser, Sulaiman Mohammed Shalaby, Amany Mohamed Alabiad, Mohamed Ali Abd-Almotaleb, Noha Ali Alorini, Mohammed Jaber, Fatima A Khayal, Eman El-Sayed
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Toxicology mechanisms and methods
Microplastics (MPs) have become a worldwide issue because of their persistence in marine organisms, their accumulation in the food chains, and their inevitable human exposure. Silymarin is a therapeutic agent used in the treatment of multiple liver diseases. The study aimed to explore the potential therapeutic effect of 2 weeks of silymarin treatme...
Frangiamone, Massimo Yemelin, Alexander Cimbalo, Alessandra Font, Guillermina Thines, Eckhard Manyes, Lara
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Toxicology mechanisms and methods
Aflatoxin B1 (AFB1) and ochratoxin A (OTA) are well-known to promote hepatotoxicity and nephrotoxicity in vivo, which may be counteracted by natural compounds like fermented whey (FW). Carbamoyl phosphate synthetase 1 (CPS1) and kidney injury molecule 1 (KIM-1) are typical biomarkers used to detect liver and kidney damage, respectively. Thus, RT-qP...
Tavakoli Pirzaman, Ali Aghajanian, Soheyla Mansoori, Razieh Al-E-Ahmad, Atiyeh Ebrahimzadeh, Manijeh Moghadamnia, Ali Akbar Kazemi, Sohrab
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Toxicology mechanisms and methods
5-fluorouracil (5-FU) is a widely used chemotherapeutic agent, and its uncontrolled blood levels contribute to toxicity. Quercetin, as an important flavonoid, has many biological effects, including anti-tumor and anti-inflammatory features. The current study investigated the synergistic effect between 5-FU and quercetin using HT-29 cell line and fi...
Azouz, Amany A Abdel-Rahman, Doaa M Messiha, Basim Anwar Shehata
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Toxicology mechanisms and methods
Despite the great importance of amphotericin B for the management of life-threatening systemic fungal infections, its nephrotoxic effect restricts its repeated administration. This study was designed to examine the prospective modulatory effects of xanthenone, an ACE2 activator, against amphotericin B nephrotoxicity. Male Wistar rats were allocated...
Erarslan, Ayse Seda Ozmerdivenli, Recep Sirinyıldız, Ferhat Cevik, Ozge Gumus, Erkan Cesur, Gokhan
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Toxicology mechanisms and methods
Ulcerative Colitis (UC) is a disease that negatively affects quality of life and is associated with sustained oxidative stress, inflammation and intestinal permeability. Vitamin D and Curcumin; It has pharmacological properties beneficial to health, including antioxidant and anti-inflammatory properties. Our study investigates the role of Vitamin D...
Berlato, Dener Gomes Bezerra Pacheco, André Lucas Ugalde, Gustavo Andrade Reginato, Fernanda Ziegler Saldanha, Geovane de Almeida Oliveira, Tiago Franco de Eller, Sarah Bairros, André Valle de
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Toxicology mechanisms and methods
Microextractions have been developed for the tricyclic antidepressants (TCAs) analysis in biological matrices, including dispersive liquid-liquid microextraction (DLLME). The proposed DLLME employed 490 µL of biological sample (whole blood or plasma), which were added 15 mg of NaCl, 10 µL of medazepam as internal standard (10 µg/mL) and 100 µL of 2...
Barbosa, Nilda V Aschner, Michael Tinkov, Alexey A Farina, Marcelo Rocha, João Batista Teixeira da
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Toxicology mechanisms and methods
Mercury is a ubiquitous environmental contaminant and can be found in inorganic (Hg0, Hg+ and Hg2+) and organic forms (chiefly CH3Hg+ or MeHg+). The main route of human, mammals and bird exposure occurs via predatory fish ingestion. Occupational exposure to Hg0 (and Hg2+) can also occur; furthermore, in gold mining areas the exposure to inorganic H...
