Duess, Johannes W Gosemann, Jan-Hendrik Puri, Prem Thompson, Jennifer
Published in
Toxicology and applied pharmacology
The pyridine derivative Y-27632 inhibits Rho-associated coiled-coil-containing protein kinase (ROCK) signaling, which is involved in numerous developmental processes during embryogenesis, primarily by controlling actin-cytoskeleton assembly and cell contractility. Somite formation requires rearrangement of the cytoskeleton and assists in major morp...
Li, Li Ding, Chunyong Zou, Chunpeng Xiong, Zhi Zhu, Weiwei Qian, Jianchang Xu, Mingjiang Zhang, Ao Liang, Guang
Published in
Toxicology and applied pharmacology
Diabetic nephropathy is the leading cause of renal failure worldwide. Elevated inflammatory signaling has been shown to lead to deterioration of renal function in human and experimental diabetes. We recently developed a salviadione derivative (compound 15a) that prevented microbial lipopolysaccharide-induced inflammatory responses, which are largel...
Li, Xiaocui Ou, Xiaowen Luo, Guangkuo Ou, Xiaojun Xie, Yushan Ying, Mengdi Qu, Wei Zuo, Huilin Qi, Xiaoxiao Wang, Ying
...
Published in
Toxicology and applied pharmacology
Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This study aimed to explore the effects of Mdr1a, Bcrp and Mrp2 on the efficacy/toxicity of MA and HA by using efflux transporter gene knockout mouse models. The analgesic and a...
Lu, Zi-Bin Liu, Shan-Hong Ou, Jin-Ying Cao, Hui-Hui Shi, Ling-Zhu Liu, Dong-Yi Tian, Chun-Yang Zheng, Yuan-Ru Zhou, Hong-Ling Liu, Jun-Shan
...
Published in
Toxicology and applied pharmacology
Wang, Yongkui Chen, Jian Chen, Jing Dong, Chao Yan, Xu Zhu, Zhongpei Lu, Pan Song, Zongmian Liu, Hongjian Chen, Songfeng
...
Published in
Toxicology and applied pharmacology
Glucocorticoids have been widely used in multiple inflammatory and autoimmune diseases. However, long-term glucocorticoid therapy may result in osteoporosis. The present study aimed to evaluate the potential therapeutic effects and investigate the underlying mechanisms of Daphnetin (Daph) on glucocorticoid-induced osteoporosis (GIOP). In vivo, male...
Zeng, Jingwen Sun, Yan Li, Xiaoqin Zhu, Jianlin Zhang, Wenchang Lu, Wenmin Weng, Yuyao Liu, Jin
Published in
Toxicology and applied pharmacology
The mechanisms by which 2,5-hexanedione (2,5-HD) exposure adversely affects reproduction are unclear. In the present study, whole neonatal mouse ovaries were exposed to 2,5-HD in vitro and then assessed for progesterone levels to determine the effects of this compound on ovary function. Ovarian histomorphological analyses were performed to assess t...
Fedan, Jeffrey S
Published in
Toxicology and applied pharmacology
Hydraulic fracturing ("fracking") is a process in which subterranean natural gas-laden rock is fractured under pressure to enhance retrieval of gas. Sand (a "proppant") is present in the fracking fluid pumped down the well bore to stabilize the fissures and facilitate gas flow. The manipulation of sand at the well site creates respirable dust (frac...
Eslami, Farhad Mahdavi, Majid Babaei, Esmaeil Hussen, Bashdar Mahmud Mostafavi, Hossein Shahbazi, Ahmad Hidayat, Hazha Jamal
Published in
Toxicology and applied pharmacology
Ciprofloxacin derivatives belong to a family of antibiotics called fluoroquinolones. Recently, these compounds have been recommended for the treatment of cancer. In the present study, we assessed the cytotoxicity of several new synthetic ciprofloxacin derivatives and the apoptosis-inducing activity of the most efficient derivative in two human myel...
Gnanaprakasam, J N Rashida López-Bañuelos, Laura Vega, Libia
Published in
Toxicology and applied pharmacology
Many antineoplastic agents induce myelosuppression and leukopenia as secondary effects in patients. The development of anticancer agents that simultaneously provoke antitumor immune response represents an important therapeutic advance. The administration of 6-pentadecyl salicylic acid (6SA) contributes to the antitumor immunity using 4 T1 breast ca...
Yang, Yuan Wang, Qinling Wang, Wenjuan Wei, Shaofeng Zeng, Qibing Zhang, Aihua
Published in
Toxicology and applied pharmacology
Semaphorin (Sema) 3A and Sema 4A are immunomodulatory molecules with a common receptor, neuropilin-1 (NRP-1), on the immune cells. Sema 3A binds to NRP-1 and inhibits T cell activation and inflammation, while Sema 4A binds to NRP-1 and promotes T cell activation and inflammation. These molecules are associated closely with the regulation of protein...
