Mutlu, Esra Gibbs, Seth T South, Natalie Pierfelice, Jessica Burback, Brian Germolec, Dori Waidyanatha, Suramya
Published in
Toxicology and applied pharmacology
Trans-resveratrol (RES) is a naturally occurring stilbene found in numerous plants and foods. Due to its widespread human exposure and lack of toxicity and carcinogenicity data, RES was nominated to the National Toxicology Program for testing. To aid the toxicology studies, the dose, sex, and species differences in RES toxicokinetics was investigat...
Xie, Jie Yu, Jun Fan, Yongsheng Zhao, Xue Su, Jianmei Meng, Yu Wu, Yu Uddin, Mohammad Burhan Wang, Chunhong Wang, Zhishan
...
Published in
Toxicology and applied pharmacology
Implications of lead (Pb) exposure in dysregulated spermatogenesis in sexually active individuals during adulthood is well established; however, the effect of Pb exposure on spermatogenesis in the early stages of puberty is not clear yet. Moreover, the mechanism of Pb mediated dysregulation of spermatogenesis in adults is also poorly understood. Ex...
Rezaei, Niloufar Sardarzadeh, Tayebeh Sisakhtnezhad, Sajjad
Published in
Toxicology and applied pharmacology
Mesenchymal stem cells (MSCs) have unique potentials, including migration and immunomodulation. Identification of the factors that enhance these activities can improve clinical applications of MSCs. This study aimed to investigate total antioxidant capacity (TAC) and migration potential of mouse MSCs exposed to thymoquinone (TQ) in vitro, and to ex...
Wang, Yuting Wang, Lei Wise, James T F Shi, Xianglin Chen, Zhimin
Published in
Toxicology and applied pharmacology
Inflammation is a physiologic response to damage triggered by infection, injury or chemical irritation. Chronic inflammation produces repeated damage to cells and tissues, which can induce a variety of human diseases including cancer. Verteporfin, an FDA approved drug, is used for the treatment of age-related macular degeneration. The anti-tumor ef...
Duan, Luqi Ramachandran, Anup Akakpo, Jephte Y Woolbright, Benjamin L Zhang, Yuxia Jaeschke, Hartmut
Published in
Toxicology and applied pharmacology
Though mitochondrial oxidant stress plays a critical role in the progression of acetaminophen (APAP) overdose-induced liver damage, the influence of mitochondrial bioenergetics on this is not well characterized. This is important, since lifestyle and diet alter hepatic mitochondrial bioenergetics and an understanding of its effects on APAP-induced ...
Chen, Yueming Li, Huachao Zhang, Weinan Qi, Wanchen Lu, Changpeng Huang, Huiliang Yang, Zhicheng Liu, Bing Zhang, Luyong
Published in
Toxicology and applied pharmacology
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer with a disappointing prognosis. The aim of this study was to investigate the anticancer effect of sesamin and the underlying mechanism. The MTT assay was used to detect the proliferation of NSCLC cells. The cell cycle and apoptosis were analyzed by flow cytometry. The protein...
Lasagni Vitar, Romina M Hvozda Arana, Ailen G Janezic, Natasha S Marchini, Timoteo Tau, Julia Martinefski, Manuela Tesone, Agustina I Racca, Lourdes Reides, Claudia G Tripodi, Valeria
...
Published in
Toxicology and applied pharmacology
The aim of the study was to evaluate the time course of the effects of urban air pollutants on the ocular surface, focusing on the morphological changes, the redox balance, and the inflammatory response of the cornea. 8-week-old mice were exposed to urban or filtered air (UA-group and FA-group, respectively) in exposure chambers for 1, 2, 4, and 12...
Ikonomov, Ognian C Sbrissa, Diego Shisheva, Assia
Published in
Toxicology and applied pharmacology
Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cytoplasmic vacuolation in all dividing cells in culture yet trigger non-apoptotic death through exces...
Rincic Mlinaric, M Durgo, K Katic, V Spalj, S
Published in
Toxicology and applied pharmacology
The aim was to explore the biological effect of nickel (Ni) and titanium (Ti) ions released from dental alloys. NiTi alloy were exposed to 40 mL of artificial saliva (pH = 4.8, t = 37 °C). The dynamics of Ni and Ti ions release during corrosion were recorded on the 3th, 7th and 14th day. Biological effect of Ni and Ti ions released from alloy was e...
Hepnarova, Vendula Muckova, Lubica Ring, Avi Pejchal, Jaroslav Herman, David Misik, Jan Hrabinova, Martina Jun, Daniel Soukup, Ondrej
Published in
Toxicology and applied pharmacology
The major function of compounds with an oxime moiety attached to a quarternary nitrogen pyridinium ring is to reactivate acetylcholinesterase inhibited by organophosphorus agent (OP). However, other oxime mechanisms (e.g. modulation of cholinergic or glutamatergic receptor) may be involved in the recovery. The main disadvantage of positively charge...
