Zeng, Jie Zhao, Yu Li, Kexun Long, Daoling Li, Wei Liang, Liang
Published in
Toxicology and applied pharmacology
WHO suggests that colon cancer incidences are rising steadily, propelling researchers to search for novel chemotherapeutic options. Metal-based chemotherapy is a potential forte to explore ruthenium-based complexes, exhibiting the capability to influence a variety of cellular targets. We discovered the chemotherapeutic effects of ruthenium-rifampic...
Werner, Jonathan A Davies, Rhian Wahlstrom, Jan Dahal, Upendra P Jiang, Min Stauber, Jonathan David, Benjamin Siska, William Thomas, Barbara Ishida, Katsu
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Published in
Toxicology and applied pharmacology
Sotorasib is a first-in class KRASG12C covalent inhibitor in clinical development for the treatment of tumors with the KRAS p.G12C mutation. In the nonclinical toxicology studies of sotorasib, the kidney was identified as a target organ of toxicity in the rat but not the dog. Renal toxicity was characterized by degeneration and necrosis of the prox...
Yaman, Belma Akpınar, Onur Kemal, Hatice S Cerit, Levent Yüksek, Ümit Söylemez, Nihat Duygu, Hamza
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Toxicology and applied pharmacology
IQOS is a novel tobacco product claimed to be safer than conventional cigarette smoking due to the heat-not-burn system. This study aimed to evaluate the acute effects of IQOS smoking on myocardial systolic and diastolic functions and also compare the acute impacts of IQOS with cigarette smoking. In this prospective study, twenty-seven healthy part...
Rathaur, Pooja Soni, Mehul N Gelat, Brijesh Rawal, Rakesh Pandya, Himanshu A Johar, Kaid
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Toxicology and applied pharmacology
Metastatic breast cancer is a prevalent life-threatening disease. Paclitaxel (PTX) is widely used in metastatic breast cancer therapy, but the side effects limit its chemotherapeutic application. Multidrug strategies have recently been used to maximize potency and decrease the toxicity of a particular drug by reducing its dosage. Therefore, we have...
Hashemzadeh, Alireza Amerizadeh, Forouzan Asgharzadeh, Fereshteh Darroudi, Majid Avan, Amir Hassanian, Seyed Mahdi Landarani, Mohammad Khazaei, Majid
Published in
Toxicology and applied pharmacology
Oxaliplatin is being used in different malignancies and several side effects are reported for patients taking Oxaliplatin, including peripheral neuropathy, nausea and vomiting, diarrhea, mouth sores, low blood counts, fatigue, loss of appetite, etc. Here we have developed a targeted anticancer drug delivery system based on folate-conjugated amine-f...
Duess, Johannes W Gosemann, Jan-Hendrik Puri, Prem Thompson, Jennifer
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Toxicology and applied pharmacology
The pyridine derivative Y-27632 inhibits Rho-associated coiled-coil-containing protein kinase (ROCK) signaling, which is involved in numerous developmental processes during embryogenesis, primarily by controlling actin-cytoskeleton assembly and cell contractility. Somite formation requires rearrangement of the cytoskeleton and assists in major morp...
Li, Li Ding, Chunyong Zou, Chunpeng Xiong, Zhi Zhu, Weiwei Qian, Jianchang Xu, Mingjiang Zhang, Ao Liang, Guang
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Toxicology and applied pharmacology
Diabetic nephropathy is the leading cause of renal failure worldwide. Elevated inflammatory signaling has been shown to lead to deterioration of renal function in human and experimental diabetes. We recently developed a salviadione derivative (compound 15a) that prevented microbial lipopolysaccharide-induced inflammatory responses, which are largel...
Li, Xiaocui Ou, Xiaowen Luo, Guangkuo Ou, Xiaojun Xie, Yushan Ying, Mengdi Qu, Wei Zuo, Huilin Qi, Xiaoxiao Wang, Ying
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Published in
Toxicology and applied pharmacology
Mesaconitine (MA) and hypaconitine (HA) are the main bioactive/toxic alkaloids of Aconitum carmichaelii Debx, and MDR1, BCRP and MRP2 are involved in their efflux in vitro. This study aimed to explore the effects of Mdr1a, Bcrp and Mrp2 on the efficacy/toxicity of MA and HA by using efflux transporter gene knockout mouse models. The analgesic and a...
Lu, Zi-Bin Liu, Shan-Hong Ou, Jin-Ying Cao, Hui-Hui Shi, Ling-Zhu Liu, Dong-Yi Tian, Chun-Yang Zheng, Yuan-Ru Zhou, Hong-Ling Liu, Jun-Shan
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Published in
Toxicology and applied pharmacology
Wang, Yongkui Chen, Jian Chen, Jing Dong, Chao Yan, Xu Zhu, Zhongpei Lu, Pan Song, Zongmian Liu, Hongjian Chen, Songfeng
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Published in
Toxicology and applied pharmacology
Glucocorticoids have been widely used in multiple inflammatory and autoimmune diseases. However, long-term glucocorticoid therapy may result in osteoporosis. The present study aimed to evaluate the potential therapeutic effects and investigate the underlying mechanisms of Daphnetin (Daph) on glucocorticoid-induced osteoporosis (GIOP). In vivo, male...
