Sauer, Ursula G. Vogel, Sandra Aumann, Alexandra Hess, Annemarie Kolle, Susanne N. Ma-Hock, Lan Wohlleben, Wendel Dammann, Martina Strauss, Volker Treumann, Silke
...
Published in
Toxicology and Applied Pharmacology
•16 OECD reference nanomaterials were tested in rat precision-cut lung slices.•Nanomaterial cytotoxicity, apoptose, oxidative stress, and inflammation were detected.•Investigating these early effects is not sufficient to predict in vivo outcome.•Reproducibility was not fully satisfactory in the glutathione and cytokine assays.•Further work is requi...
MadanKumar, Perumal NaveenKumar, Perumal Manikandan, Samidurai Devaraj, Halagowder NiranjaliDevaraj, Sivasithamparam
Published in
Toxicology and Applied Pharmacology
The anti-fibrotic effect of morin was examined in LX-2 cells (culture-activated human hepatic stellate cells) and in diethylnitrosamine induced rat model of liver fibrosis. The in vitro study was designed to determine whether morin affects the survival of cultured LX-2 cells, while the in vivo study was designed to evaluate the antioxidant and anti...
Chen, Jiao Shetty, Sreerama Zhang, Ping Gao, Rong Hu, Yuxin Wang, Shuxia Li, Zhenyu Fu, Jian
Published in
Toxicology and applied pharmacology
The presence of endotoxin in blood can lead to acute kidney injury (AKI) and septic shock. Resolvins, the endogenous lipid mediators derived from docosahexaenoic acid, have been reported to exhibit potent anti-inflammatory action. Using a mouse model of lipopolysaccharide (LPS)-induced AKI, we investigated the effects of aspirin-triggered resolvin ...
Zhang, Youcai Limaye, Pallavi B. Renaud, Helen J. Klaassen, Curtis D.
Published in
Toxicology and Applied Pharmacology
•Various antibiotics have different effects on intestinal bacteria.•Antibiotics alter bile acid composition in mouse liver and intestine.•Antibiotics influence genes involved in bile acid homeostasis.•Clostridia appear to be important for secondary bile acid formation.
Kaphalia, Lata Boroumand, Nahal Hyunsu, Ju Kaphalia, Bhupendra S. Calhoun, William J.
Published in
Toxicology and Applied Pharmacology
Guo, Lei Xiao, Yongsheng Wang, Yinsheng
Published in
Toxicology and Applied Pharmacology
Human exposure to arsenic in drinking water is a widespread public health concern, and such exposure is known to be associated with many human diseases. The detailed molecular mechanisms about how arsenic species contribute to the adverse human health effects, however, remain incompletely understood. Monomethylarsonous acid [MMA(III)] is a highly t...
Yin, Xia Zhou, Shanshan Zheng, Yang Tan, Yi Kong, Maiying Wang, Bo Feng, Wenke Epstein, Paul N. Cai, Jun Cai, Lu
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Published in
Toxicology and Applied Pharmacology
•The effect of intermittent hypoxia (IH) on cardiac metallothionein (MT)•Cardiac MT expression was up-regulated in response to 3-day IH.•Exposure to 4- or 8-week IH downregulated cardiac MT expression.•Overexpression of cardiac MT protects from IH-induced cardiac damage.•Global deletion of MT gene made the heart more sensitive to IH damage.
Ma, Hai-Ying Sun, Dong-Xue Cao, Yun-Feng Ai, Chun-Zhi Hu, Cui-Min Jiang, Changtao Dong, Pei-Pei Sun, Xiao-Yu Hong, Mo Tanaka, Naoki
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Published in
Toxicology and Applied Pharmacology
Madden, Jill A. Hoyer, Patricia B. Devine, Patrick J. Keating, Aileen F.
Published in
Toxicology and Applied Pharmacology
•PM depletes all stage ovarian follicles in a temporal pattern.•A volatile ovotoxic compound is liberated from PM.•The volatile metabolite depletes primordial follicles.
Nishizato, Yohei Imai, Satoki Okahashi, Noriko Yabunaka, Atsushi Kunimatsu, Takeshi Kikuchi, Kaoru Yabuki, Masashi
Published in
Toxicology and Applied Pharmacology
•SMP-028 inhibits neutral CEase more strongly than other steroidogenic enzymes in rats.•Inhibition of neutral CEase in rats by SMP-028 suppresses steroidogenesis in vivo.•SMP-028 does not inhibit neutral CEase in monkeys in vivo.•Steroidogenesis pathway in monkeys treated with SMP-028 was not suppressed.•SMP-028 may not inhibit LIPE in humans in vi...
