Edible plant-derived exosomal microRNAs: Exploiting a cross-kingdom regulatory mechanism for targeting SARS-CoV-2
Published in Toxicology and Applied Pharmacology
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Chloroquine may induce endothelial injury through lysosomal dysfunction and oxidative stress
Published in Toxicology and Applied Pharmacology
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The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition ...
...Published in Toxicology and Applied Pharmacology
• Metabolic modification has been adapted to identify delayed (weeks) mitochondrial dysfunction. • Fialuridine induces delayed mitochondrial dysfunction and toxicity at physiologically relevant exposures. • Inhibition of mitochondrial replication leads to decreased oxidative phosphorylation before cell death. • HepaRG cells are a more suitable mode...
Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach
Published in Toxicology and Applied Pharmacology
• Lopinavir/ritonavir affect genes involved in immune system and lipid metabolism • Cardiotoxicity, inflammation, dyslipidemias – lopinavir/ritonavir therapy main risk • Chloroquine/azithromycin interact with genes linked to cytokine regulation • Chloroquine affects two genes more than hydroxychloroquine (BCL2L1 and CYP3A4) • CVD, GIT, skin disease...
Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH ...
Published in Toxicology and applied pharmacology
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). This metabolism occurs in bone marrow (BM) mesenchymal stem cells (MSC), which sustain hematopoietic stem and progenitor cells (HSPC). In BM, CYP1B1-mediated metabolism of 7, 12-dimethy...
Formation of lamellar body-like structure may be an initiator of didecyldimethylammonium chloride-induced toxic response...
Published in Toxicology and applied pharmacology
Due to the pandemic of coronavirus disease 2019, the use of disinfectants is rapidly increasing worldwide. Didecyldimethylammonium chloride (DDAC) is an EPA-registered disinfectant, it was also a component in humidifier disinfectants that had caused idiopathic pulmonary diseases in Korea. In this study, we identified the possible pulmonary toxic re...
Corrigendum to “A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety par...
...Published in Toxicology and Applied Pharmacology
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
...Published in Toxicology and applied pharmacology
hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and a lack of statistical quantification of experimental variability. Since the new cardiac safety paradigm being discussed by the International Council...
Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anestheti...
...Published in Toxicology and applied pharmacology
Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in the in vivo anesthetized cardiovascular guinea pig...
A toxicogenomic approach for the risk assessment of the food contaminant acetamide.
...Published in Toxicology and applied pharmacology
Acetamide (CAS 60-35-5) is detected in common foods. Chronic rodent bioassays led to its classification as a group 2B possible human carcinogen due to the induction of liver tumors in rats. We used a toxicogenomics approach in Wistar rats gavaged daily for 7 or 28 days at doses of 300 to 1500 mg/kg/day (mkd) to determine a point of departure (POD) ...
