Couderc, Sylvain Gabriel, Anthony Decheiver, Sarah N'Zoué Kanga, Sita Fikanni, Amine Flint, Harry Pihan, Franck Sahar, Abdallah Tifrea, Marius Tifrea, Andrea
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Published in
Therapeutic drug monitoring
This study presents the case of a 19-year-old woman who attempted suicide by ingesting 11.25 g of venlafaxine (V). She was admitted to the hospital with severe biventricular dysfunction, progressing to cardiac arrest requiring extracorporeal circulatory life support for 11 days. The pharmacokinetics of venlafaxine during impaired cardiac output and...
Berneri, Massimo Jha, Uma O'Halloran, Seán Salman, Sam Wickramasinghe, Shanek Kendrick, Kevin Nguyen, Jessica Joyce, David A
Published in
Therapeutic drug monitoring
Clozapine is unique in its capacity to ameliorate severe schizophrenia but at high risk of toxicity. A relationship between blood concentration and clinical response and evidence for concentration-response relationships to some adverse effects justify therapeutic drug monitoring of clozapine. However, the relationship between drug dose and blood co...
Robin, Julien Albouy, Marion Jourdain, Bernard Binson, Guillaume Sauvaget, Alexis Pierre-Eugène, Pascale Wu, Luyao Migeot, Virginie Dupuis, Antoine Venisse, Nicolas
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Published in
Therapeutic drug monitoring
In 2021, French public authorities initiated the fourth National Environmental Health Plan to prevent environment-related health risks. This plan primarily focuses on the sensitization of health professionals and health care institutions. Endocrine disruptors (EDs) are environmental factors associated with several adverse health effects, such as re...
Lao, Qianying Wu, Xuanyu Zheng, Xinxin Hu, Jinwei Huang, Siqi Li, Danying Du, Yao Yang, Na Zhu, Huaijun
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Therapeutic drug monitoring
Liver cancer is the second highest cause of cancer-related deaths worldwide. It is commonly treated with liver transplantation, where tacrolimus is typically used as an antirejection immunosuppressant. The purpose of this study was to evaluate the effect of tacrolimus time in therapeutic range (TTR) on liver cancer recurrence in liver transplant re...
Lin, Lishi Barkman, Hannerieke J Smit, Egbert F de Langen, Adrianus J Steeghs, Neeltje Beijnen, Jos H Huitema, Alwin D R
Published in
Therapeutic drug monitoring
the study aims to evaluate whether high plasma trough levels of the kinase inhibitors (K.I.s) crizotinib, alectinib, osimertinib, dabrafenib, and trametinib were associated with a higher risk of toxicity in non-small-cell lung cancer patients. In this retrospective cohort study, patients with non-small-cell lung cancer treated with the selected K.I...
Robosa, Roselle S Lau, Cindy Stojanova, Jana Chin, Cheau Wern Marriott, Deborah J E
Published in
Therapeutic drug monitoring
Ceftazidime-avibactam (CTZ-AVM) is a novel cephalosporin/beta-lactamase inhibitor with broad-spectrum activity against multidrug-resistant Pseudomonas aeruginosa . Ceftazidime-induced neurotoxicity is a well-described adverse effect, particularly in patients with renal insufficiency. However, appropriate dosing of ceftazidime-avibactam in patients ...
Granger, Douglas A Parkin, Georgia M Buspavanich, Pichit Findeisen, Peter Rietschel, Marcella McCarthy, Michael J Thomas, Elizabeth A
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Therapeutic drug monitoring
Lithium medication is considered to be the first-line treatment for bipolar disorder as a monotherapy, and for treatment-resistant depression with lithium augmentation. However, because of potential toxicity, lithium levels must be monitored frequently. Recent studies have demonstrated a significant correlation between lithium levels measured in se...
Li, Qiaoqiao Tang, Tiantian Zhang, Min Li, Lixian Chen, Wanyi
Published in
Therapeutic drug monitoring
Sunitinib (SUN) malate is an oral, multitargeted, tyrosine kinase inhibitor approved for the treatment of metastatic renal cell carcinoma, imatinib-resistant or imatinib-intolerant gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. SUN has a narrow therapeutic window and high variability in interpatient pharmacokinetic parameter...
Coulibaly, Balla Maire, Pascal Guitton, Jêrome Pelletier, Solenne Tangara, Moustapha Aulagner, Gilles Goutelle, Sylvain
Published in
Therapeutic drug monitoring
Vancomycin dosing remains challenging in patients receiving intermittent hemodialysis, especially in developing countries, where access to therapeutic drug monitoring and model-based dose adjustment services is limited. The objectives of this study were to describe vancomycin population PK in patients receiving hemodialysis in a Malian and French c...
Fujita, Yuito Murai, Mariko Muraki, Shota Suetsugu, Kimitaka Tsuchiya, Yuichi Hirota, Takeshi Matsunaga, Naoya Ieiri, Ichiro
Published in
Therapeutic drug monitoring
Perampanel (PER) is an oral antiepileptic drug and its concomitant use with carbamazepine (CBZ) leads to decreased PER concentrations. However, the magnitude of its influence may vary, depending on the dynamics of the enzyme induction properties of CBZ. This study aimed to develop a population pharmacokinetic (PPK) model considering the dynamics of...
