Comment on "Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples".
Published in Therapeutic drug monitoring
Population Pharmacokinetic Modeling of Vancomycin in Thai Patients with Heterogeneous and Unstable Renal Function
Published in Therapeutic drug monitoring
Background: Vancomycin is widely used to treat gram-positive bacterial infections. However, given significant interpatient variability in its pharmacokinetics, maintaining plasma concentrations is difficult within its characteristically narrow therapeutic window. This is especially challenging in patients with unstable renal function. Thus, the aim...
Physician Perspective and Challenges Ordering/Interpreting Lab Tests Related to the Opioid Crisis in America.
Published in Therapeutic drug monitoring
The opioid crisis is a profound public health crisis in the United States. It has significantly increased morbidity and mortality in our nation. There are many contributing factors to the opioid crisis, including a strong national and international interest to treat pain as effectively as possible. To combat this crisis, numerous strategies have be...
Impact of the Opioid Epidemic on Drug Testing.
Published in Therapeutic drug monitoring
Rapid Simultaneous Determination of Fourteen Antidepressants and Thirteen Antipsychotics in Human Plasma by Using High-p...
Published in Therapeutic drug monitoring
A comprehensive, stable, and efficient high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method was developed for rapidly analyzing 14 antidepressants and 13 antipsychotics in human plasma for routine clinical therapeutic drug monitoring (TDM). Simple protein precipitation was used for the pretreatment of plasma samples; ...
Plasma Concentrations and Safety of Lopinavir/ritonavir in COVID-19 Patients A Short Communication.
...Published in Therapeutic drug monitoring
Although the efficacy of lopinavir/ritonavir has not been proven, it has been proposed as an off-label treatment for COVID-19. Previously, it has been reported that the plasma concentrations of lopinavir significantly increase in inflammatory settings. As COVID-19 may be associated with major inflammation, assessing the plasma concentrations and sa...
Therapeutic Drug Monitoring of Long-Acting Injectable Antipsychotic Drugs.
...Published in Therapeutic drug monitoring
The use of therapeutic drug monitoring (TDM) to guide treatment with long-acting injectable (LAI) antipsychotics, which are increasingly prescribed, remains a matter of debate. The aim of this review was to provide a practical framework for the integration of TDM when switching from an oral formulation to the LAI counterpart, as well as in maintena...
Perils of Antithrombotic Transitions: Effect of Oral Factor Xa Inhibitors on the Heparin Antifactor Xa Assay.
Published in Therapeutic drug monitoring
Oral factor Xa inhibitors (OFXais) may interfere with the heparin antifactor Xa (antiXa) assay. The best method to measure heparin activity during the transition from an OFXai to intravenous (IV) unfractionated heparin (UFH) remains unknown. This study aimed to assess the safety and effectiveness of transitioning from an OFXai to UFH. A retrospecti...
Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric...
Published in Therapeutic drug monitoring
The aim of the study was to investigate how age and genetic polymorphisms of UGT1A6 and UGT2B7 contribute to the concentrations of valproic acid (VPA) and its hepatotoxic metabolites in Chinese pediatric patients with epilepsy. A total of 122 children with epilepsy were genotyped at 19T>G, 541A>G, and 552A>C in UGT1A6 and -161C>T and 802C>T in UGT2...
Measuring Intracellular Concentrations of Calcineurin Inhibitors: Expert Consensus from the International Association of...
...Published in Therapeutic drug monitoring
Therapeutic drug monitoring (TDM) of the 2 calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporin A, has resulted in improvements in the management of patients who have undergone solid organ transplantation. As a result of TDM, acute rejection (AR) rates and treatment-related toxicities have been reduced. Irrespective, AR and toxicity stil...
