Nanotechnology-driven therapies for neurodegenerative diseases: a comprehensive review.
Published in Therapeutic delivery
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Probucol-bile acid based nanoparticles protect auditory cells from oxidative stress: an in vitro study.
Published in Therapeutic delivery
Hearing loss affects millions of people worldwide, and its prevalence is expected to double by 2050. Current treatments have limitations, pushing researchers to explore new options. Oxidative stress is a key player in hearing loss and is known to damage inner ear hair cells. While antioxidants, known for their protective effects, hold promise, deli...
Investigating anti-cancer activity of dual-loaded liposomes with thymoquinone and vitamin C.
Published in Therapeutic delivery
Background: Thymoquinone (TQ) and vitamin C (Vit C) have demonstrated individual anticancer effects in various studies. TQ exhibits inhibitory properties against tumor growth, induces apoptosis, while Vit C protects against DNA damage and oxidative stress. Aim: Formulation of TQ and Vit C combination into liposomes using two methods and investigate...
Synthesis and characterization of fullerene-based nanocarrier for targeted delivery of quercetin to the brain.
Published in Therapeutic delivery
In our study, we developed a new method to deliver a natural substance called quercetin into the brain for the treatment of Alzheimer's disease. Quercetin is known for its health benefits, especially in protecting brain cells. We combined quercetin with a tiny carbon-based material called fullerene, which looks like a soccer ball, to create a new c...
Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery....
Published in Therapeutic delivery
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Formulation, optimization and evaluation of amisulpride-loaded niosomal intranasal gel for brain targeting.
Published in Therapeutic delivery
Schizophrenia is a serious mental illness causing intense symptoms like hallucinations and delusions. Medicines like amisulpride can help, but they have problems like not dissolving well. The brain's defenses also make it hard for medicines to work. People are trying to send medicine through the nose to avoid these problems. These researchers devel...
In situ gastric floating gel of atazanavir sulphate for sustained release: formulation, optimization and evaluation.
Published in Therapeutic delivery
In our study, we wanted to create a gel for a medicine called atazanavir sulphate. This gel can float in the stomach for a long time and slowly release the medicine. We mixed atazanavir sulphate with something called β-cyclodextrin, and this mixture made the medicine dissolve better in water. We used this mixture to make our floating gel, which can...
Bilosomes in brain drug delivery.
Published in Therapeutic delivery
Ophthalmic nano-bioconjugates: critical challenges and technological advances.
Published in Therapeutic delivery
Ophthalmic disease can cause permanent loss of vision and blindness. Easy-to-administer topical and systemic treatments are preferred for treating sight-threatening disorders. Typical ocular anatomy makes topical and systemic ophthalmic drug delivery challenging. Various novel nano-drug delivery approaches are developed to attain the desired bioava...
Cell-penetrating peptides are widely used molecular transporter for peptide delivery in cancer: recent advancements.
Published in Therapeutic delivery
