Ruan, Huanrong Zhao, Hulei Wang, Jiajia Zhang, Hailong Li, Jiansheng
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Therapeutic advances in respiratory disease
The readmission rate following hospitalization for chronic obstructive pulmonary disease (COPD) is surprisingly high, and frequent readmissions represent a higher risk of mortality and a heavy economic burden. However, information on all-cause readmissions in patients with COPD is limited. This study aimed to systematically summarize all-cause COPD...
Wei, Ting-Ting Zhang, Jia-Feng Cheng, Zhuo Jiang, Lei Li, Jiang-Yan Zhou, Lin
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Therapeutic advances in respiratory disease
The differential diagnosis of malignant pleural effusion (MPE) and benign pleural effusion (BPE) presents a clinical challenge. In recent years, the use of artificial intelligence (AI) machine learning models for disease diagnosis has increased. This study aimed to develop and validate a diagnostic model for early differentiation between MPE and BP...
Peng, Yun Dai, Bing Zhao, Hong-Wen Wang, Wei Kang, Jian Hou, Hai-Jia Tan, Wei
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Therapeutic advances in respiratory disease
High-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) are important treatment approaches for acute hypoxemic respiratory failure (AHRF) in coronavirus disease 2019 (COVID-19) patients. However, the differential impact of HFNC versus NIV on clinical outcomes of COVID-19 is uncertain. We assessed the effects of HFNC versus NIV (interface o...
Messous, Salma Trabelsi, Imen Bel Haj Ali, Khaoula Abdelghani, Ahmed Ben Daya, Yosra Razgallah, Rabie Grissa, Mohamed Habib Beltaief, Kaouthar Mezgar, Zied Belguith, Asma
...
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Therapeutic advances in respiratory disease
Duration of antibiotic treatment in acute exacerbation of COPD (AECOPD) is most commonly based on expert opinion. Typical administration periods range from 5 to 7 days. A 2-day course with levofloxacin was not previously assessed. We performed a randomized clinical trial to evaluate the efficacy of 2-day versus 7-day treatment with levofloxacin in ...
Karlsson Sundbaum, Johanna Konradsen, Jon R Vanfleteren, Lowie E G W Axelsson Fisk, Sten Pedroletti, Christophe Sjöö, Yvonne Syk, Jörgen Sterner, Therese Lindberg, Anne Tunsäter, Alf
...
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Therapeutic advances in respiratory disease
Severe asthma increases the risk of severe COVID-19 outcomes such as hospitalization and death. However, more studies are needed to understand the association between asthma and severe COVID-19. A cohort of 150,430 adult asthma patients were identified in the Swedish National Airway Register (SNAR) from 2013 to December 2020. Data on body mass inde...
Cho, Hyun Kyu Chung, Man Pyo Soo Lee, Kyung Chung, Myung Jin Han, Joungho Kwon, O Jung Yoo, Hongseok
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Therapeutic advances in respiratory disease
Several studies have reported favorable outcomes of nonspecific interstitial pneumonia (NSIP); however, its prognosis and prognostic factors remain unclear. This study aimed to determine the outcomes of fibrotic NSIP and the prognostic factors for progression, relapse, and survival. In this retrospective study, we reviewed the clinical data of 204 ...
Melamed, Roman Paz, Francisco Jepsen, Stacy Smith, Claire Saavedra, Ramiro Mulder, Maximilian Masood, Adnan Huelster, Joshua Kirkland, Lisa Guenther, Alena
...
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Therapeutic advances in respiratory disease
Mechanical ventilation (MV) in coronavirus disease 2019 (COVID-19) patients is associated with high mortality and extensive resource utilization. The aim of this study was to investigate prognostic factors and outcomes associated with prolonged mechanical ventilation (PMV) in COVID-19 patients. This was a retrospective cohort study of COVID-19 pati...
Garcia-Robledo, Juan Esteban Rosell, Rafael Ruíz-Patiño, Alejandro Sotelo, Carolina Arrieta, Oscar Zatarain-Barrón, Lucia Ordoñez, Camila Jaller, Elvira Rojas, Leonardo Russo, Alessandro
...
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Therapeutic advances in respiratory disease
Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted therapies against these oncogenes in the hope of personalized treatment based on the tumor's molecular genomics. Th...
Burghard, Marcella Takken, Tim Nap-van der Vlist, Merel M Nijhof, Sanne L van der Ent, C Kors Heijerman, Harry G M Hulzebos, H J Erik
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Therapeutic advances in respiratory disease
[1] To investigate the cardiorespiratory fitness (CRF) levels in children and adolescents with cystic fibrosis (CF) with no ventilatory limitation (ventilatory reserve ⩾ 15%) during exercise, and [2] to assess which physiological factors are related to CRF. A cross-sectional study design was used in 8- to 18-year-old children and adolescents with C...
Butāne, Līna Spilva-Ekerte, Liene Šablinskis, Matīss Skride, Andris Šmite, Daina
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Therapeutic advances in respiratory disease
Pulmonary arterial hypertension (PAH) is a rare, chronic, progressive, and life-threatening cardiopulmonary disease. This study investigated the impact of an individually tailored 12 weeks home-based physiotherapy program in PAH patients, with the aim to evaluate change in exercise capacity and daily physical activity level. This was an analysis of...
