Sklienka, Peter Burša, Filip Frelich, Michal Máca, Jan Vodička, Vojtech Straková, Hana Bílená, Markéta Romanová, Tereza Tomášková, Hana
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Therapeutic advances in respiratory disease
Enhancing the safety and effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in awake, spontaneously breathing patients with the most severe form of COVID-19-related acute respiratory distress syndrome (ARDS)Why Was the Study Done? Extracorporeal membrane oxygenation (ECMO) represents a life-saving therapeutic approach that ensures ...
Huang, Hui Wang, Qian Xu, Zuojun
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Therapeutic advances in respiratory disease
Fibrosing interstitial lung diseases (FILDs) other than idiopathic pulmonary fibrosis (IPF) can develop into progressive pulmonary fibrosis (PPF) despite initial management. A substantial proportion of patients with non-IPF interstitial lung diseases (ILDs) progress to PPF, including connective tissue disease-associated ILD (such as rheumatoid arth...
Lynn, Heather Sun, Xiaoguang Casanova, Nancy G Bime, Christian Reyes Hernon, Vivian Lanham, Clayton Oita, Radu C Ramos, Nikolas Sun, Belinda Coletta, Dawn K
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Therapeutic advances in respiratory disease
eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a novel DAMP and TLR4 ligand, is a druggable ARDS therapeutic target with NAMPT promoter SNPs associated with ARDS severity. This study assesses the previously unknown influence of NAMPT promoter SNPs on NAMPT transcription, eNAMPT secretion, and ARDS severity. Human lung endothelial ce...
Mai, Tu H Han, Lyrialle W Hsu, Joy C Kamath, Nikhil Pan, Lin
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Therapeutic advances in respiratory disease
Drug development for idiopathic pulmonary fibrosis (IPF) has been challenging due to poorly understood disease etiology, unpredictable disease progression, highly heterogeneous patient populations, and a lack of robust pharmacodynamic biomarkers. Moreover, because lung biopsy is invasive and dangerous, making the extent of fibrosis as a direct long...
Gaultier, Sébastien Puscas, Tania Pastre, Jean Gibault, Laure Arlet, Jean-Benoît Cauquil, Cécile Michon, Adrien
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Therapeutic advances in respiratory disease
We present a case report of transbronchial cryobiopsy proven diffuse amyloid cystic lung disease complicating a homozygous Val122Ile (V122I) transthyretin mutated amyloidosis (ATTRm). To the best of our knowledge, this is the first case in the literature reporting such pulmonary lesions in ATTRm amyloidosis, and notably diagnosed through cryobiopsy...
Bai, Haodong Shi, Cuiqin Yu, Sue Wen, Siwan Sha, Bingxian Xu, Xianghuai Yu, Li
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Therapeutic advances in respiratory disease
The diagnosis of cough-variant asthma (CVA) is based on bronchial provocation test, which is challenging to be conducted. Most CVA patients have type 2 airway inflammation and small airway dysfunction. FeNO200, reflecting small airway inflammation, may be used to diagnose CVA. This study aimed to explore and compare the value of lower airway exhale...
Zhang, Mengru Morice, Alyn H Si, Fengli Zhang, Li Chen, Qiang Wang, Shengyuan Zhu, Yiqing Xu, Xianghuai Yu, Li Qiu, Zhongmin
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Therapeutic advances in respiratory disease
The management of refractory chronic cough (RCC) is a great challenge. Neuromodulators have long been used for RCC with imperfect efficacy. We summarized the outcomes of the current treatments used at our specialist cough clinic, which provides a guideline-led service and real-world experience for the future management of RCC. This is a single-cent...
Wu, Yuhao Xi, Linyun Pan, Zhengxia Wu, Chun Li, Hongbo
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Therapeutic advances in respiratory disease
Pulmonary sequestration (PS) is a rare congenital malformation, which mainly contains two variants involving extralobar and intralobar sequestrations. Extralobar sequestrations (ELS) are isolated from the remaining lung tissue and have their visceral pleura. Herein, we report the first case of a torsed ELS associated with congenital lobar emphysema...
Huang, Chienhsiu Kuo, Sufang Lin, Lichen Yang, Yalun
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Therapeutic advances in respiratory disease
N-acetylcysteine (NAC) may reduce acute exacerbations of chronic obstructive pulmonary disease through an antioxidant effect. Due to the heterogeneity in studies, the currently available data do not confirm the efficacy of oral NAC therapy in chronic obstructive pulmonary disease patients. We hypothesize that chronic obstructive pulmonary disease p...
Jiang, Meng-Ping Wen, Jian-Xun Hai, Ling Jiang, Ting-Wang Huang, Jin-Hong Chen, Hong Wang, Ya-Fei Zheng, Wen-Qi Hu, Zhi-De Yan, Li
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Therapeutic advances in respiratory disease
Pleural fluid (PF) carcinoembryonic antigen (CEA) is a widely used diagnostic marker for malignant pleural effusion (MPE). Recent studies revealed that PF to serum CEA was also a promising diagnostic parameter for MPE. We aimed to investigate whether PF to serum CEA ratio and delta CEA (PF minus serum CEA) provided added value to PF CEA in diagnosi...
