Demanelis, Kathryn Tong, Lin Pierce, Brandon L
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Telomere length (TL) shortens over time in most human cell types and is a potential biomarker of aging. However, the causal association of TL on physical and cognitive traits that decline with age has not been extensively examined in middle-aged adults. Using a Mendelian randomization (MR) approach, we utilized genetically increased TL (GI-TL) to e...
Jain, Purva Bellettiere, John Glass, Nicole LaMonte, Michael J Di, Chongzhi Wild, Robert A Evenson, Kelly R LaCroix, Andrea Z
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Self-reported time spent standing has been associated with lower risk of mortality. No previous studies have examined this association using device-measured standing. This was a prospective cohort study of 5878 older (median age = 80 years), racial/ethnically diverse, community-dwelling women in the WHI Objective Physical Activity and Cardiovascula...
MacNeil, Lauren G Tarnopolsky, Mark A Crane, Justin D
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Aging results in a chronic, pro-inflammatory state which can promote and exacerbate age-associated diseases. In contrast, physical activity in older adults improves whole body health, protects against disease, and reduces inflammation, but the elderly are less active making it difficult to disentangle the effects of aging from a sedentary lifestyle...
Wahl, Devin Cavalier, Alyssa N Smith, Meghan Seals, Douglas R LaRocca, Thomas J
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Transcripts from non-coding repetitive elements (RE) in the genome may be involved in aging. However, they are often ignored in transcriptome studies on healthspan and lifespan, and their role in healthy aging interventions has not been characterized. We analyze RE in RNA-seq datasets from mice subjected to robust healthspan- and lifespan-increasin...
Rodríguez, Enrique Hakkou, Mohammed Hagen, Tory M Lemieux, Hélène Blier, Pierre U
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
The role played by mitochondrial function in the aging process has been a subject of intense debate in the past few decades, as part of the efforts to understand the mechanistic basis of longevity. The mitochondrial oxidative stress theory of aging (MOSTA) suggests that a progressive decay of this organelle's function leads to an exacerbation of ox...
Bondarev, Dmitriy Finni, Taija Kokko, Katja Kujala, Urho M Aukee, Pauliina Kovanen, Vuokko Laakkonen, Eija K Sipilä, Sarianna
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
To examine longitudinal changes in physical performance during the menopausal transition and the role of physical activity (PA) in these changes. Based on follicle-stimulating hormone levels and bleeding diaries, women (47-55 years) were classified as early (n=89) and late perimenopausal (n=143) and followed prospectively until postmenopausal statu...
Wanigatunga, Amal A Wang, Hang An, Yang Simonsick, Eleanor M Tian, Qu Davatzikos, Christos Urbanek, Jacek K Zipunnikov, Vadim Spira, Adam P Ferrucci, Luigi
...
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Larger brain volumes are often associated with more free-living physical activity (PA) in cognitively normal older adults. Yet, whether greater brain volumes are associated with more favorable (less fragmented) PA patterns, and whether this association is stronger than with total PA, remains unknown. Brain magnetic resonance imaging and wrist-worn ...
Berg, Ole Kristian Kwon, Oh Sung Hureau, Thomas J Clifton, Heather L Thurston, Taylor S Le Fur, Yann Jeong, Eun-Kee Trinity, Joel D Richardson, Russell S Wang, Eivind
...
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Maximal strength training (MST) results in robust improvements in skeletal muscle force production, efficiency, and mass. However, the effects of MST on muscle mitochondria are still unknown. Accordingly, the purpose of this study was to examine, from the molecular level to whole-muscle, mitochondrial adaptations induced by 8 weeks of knee-extensio...
Zampino, Marta Semba, Richard D Adelnia, Fatemeh Spencer, Richard G Fishbein, Kenneth W Schrack, Jennifer A Simonsick, Eleanor M Ferrucci, Luigi
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength, and fitness, but while the decline in these phenotypes has been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondria...
Coyle, Peter C Perera, Subashan Shuman, Valerie VanSwearingen, Jessie Brach, Jennifer S
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
The Figure-of-8-Walk test (F8WT) is a performance measure of the motor skill of walking. Unlike walking speed over a straight path, it captures curved path walking, which is essential to real-world activity, but meaningful cut-points have yet to be developed for the F8WT. A secondary analysis of 421 community-dwelling older adults (mean age 80.7 ± ...
