Cho, Gwang Moo Lee, Seo-Yeon Park, Jung Hwa Kim, Min Jae Park, Kyoung-Jun Choi, Byung Tae Shin, Yong-Il Kim, Nam Gyun Shin, Hwa Kyoung
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Photobiomodulation using low-level light-emitting diode can be rapidly applied in neurological and physiological disorders safely and noninvasively. Photobiomodulation is effective for chronic diseases because of fewer side effects than drugs. Here we investigated the effects of photobiomodulation using light-emitting diode on amyloid plaques, glio...
Muñoz, Vitor Rosetto Gaspar, Rafael Calais Kuga, Gabriel Keine Pavan, Isadora Carolina Betim Simabuco, Fernando Moreira da Silva, Adelino Sanchez Ramos de Moura, Leandro Pereira Cintra, Dennys Esper Ropelle, Eduardo Rochete Pauli, José Rodrigo
...
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
The insulin receptor substrate 1 regulates insulin-mediated glucose uptake and is a target of Rho-kinase (Rock); however, the relationship between age-related insulin resistance and Rock signaling specifically in skeletal muscle and adipose tissue is unknown. We evaluated the content and activity of Rock in C2C12 myotubes, and in skeletal muscle an...
Ham, Sung Yeon Nam, Sang Beom Kwak, Young-Lan Kim, Tae Lim Park, Jong-Kwang Shim, Yon Hee
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Age and acute hyperglycemia are known risk factors of myocardial ischemia-reperfusion injury. We investigated age-related difference in the effect of acute hyperglycemia on myocardial ischemia-reperfusion injury in Sprague-Dawley rats (young, 3 months; middle-aged, 10-12 months; and old, 22-24 months). The rats received 1.2 g/kg dextrose or normal ...
Diaz-Ruiz, Carmen Villar-Cheda, Begoña Dominguez-Meijide, Antonio Garrido-Gil, Pablo Guerra, Maria J Labandeira-Garcia, Jose L
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Sirtuin 3 (SIRT3) and angiotensin play a major role in aging-related disorders. Both modulate oxidative stress and neurodegeneration. We investigated the interaction between SIRT3 and angiotensin II (AngII) in the dopaminergic system. Both in vivo and in vitro, treatment with AngII decreased SIRT3 expression, which was reversed by angiotensin type ...
Armstrong, Nicole M An, Yang Ferrucci, Luigi Deal, Jennifer A Lin, Frank R Resnick, Susan M
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Hearing impairment (HI) could be a risk factor for cognitive decline, but cognition could plausibly also affect psychoacoustic assessment of hearing with audiometry. We examined the temporal sequence of hearing and cognitive function among nondemented, community-dwelling older adults. Hearing and cognition were assessed between 2012 and 2015 and 2 ...
Armstrong, Nicole M Deal, Jennifer A Betz, Joshua Kritchevsky, Stephen Pratt, Sheila Harris, Tamara Barry, Lisa C Simonsick, Eleanor M Lin, Frank R
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Depressive symptoms and hearing loss (HL) are independently associated with increased risk of incident disability; whether the increased risk is additive is unclear. Cox Proportional Hazards models were used to assess joint associations of HL (normal, mild, moderate/severe) and late-life depressive symptoms (defined by a score of ≥8 on the 10-item ...
Jungert, Alexandra Neuhäuser-Berthold, Monika
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Cross-sectional studies indicate an age-related decline in vitamin B6 status. Because longitudinal studies are lacking, the present study investigates the long-term association between age and vitamin B6 status in older adults by considering potential confounding factors. The study population consists of 249 women and 111 men aged ≥ 60 years, who h...
Strömmer, Juho M Davis, Simon W Henson, Richard N Tyler, Lorraine K Campbell, Karen L
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Physical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed within the same, population-based sample (critical if conclusions are to extend to the wider population). Here, using diffus...
Yamagishi, Sho-Ichi
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Bardon, Laura A Streicher, Melanie Corish, Clare A Clarke, Michelle Power, Lauren C Kenny, Rose Anne O'Connor, Deirdre M Laird, Eamon O'Connor, Eibhlis M Visser, Marjolein
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Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Older adults are at increased risk of malnutrition, which is associated with poorer health, quality of life, and worse disease outcomes. This study identifies predictors of incident malnutrition using data from a subsample (n = 1,841) of The Irish Longitudinal Study on Ageing. Participants were excluded if they were less than 65 years, missing body...
