Harris, Rebekah Strotmeyer, Elsa S Sharma, Leena Kwoh, C Kent Brach, Jennifer S Boudreau, Robert Cauley, Jane A
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Knee osteoarthritis (KOA) is the most prevalent type of OA and a leading cause of disability in the United States. Falls are a major public health concern in older adults. Our aim was to examine how the severity of radiographic KOA affects recurrent falls in a cohort of middle-aged and older individuals enrolled in the Osteoarthritis Initiative. Ab...
Ha, Sugyeong Yang, Yejin Won Kim, Jeong Son, Minjung Kim, Doyeon Kim, Mi-Jeong Im, Dong-Soon Young Chung, Hae Chung, Ki Wung
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
The age-associated functional decline of the kidney is accompanied by structural changes including glomerular sclerosis and interstitial fibrosis. Aging kidneys also exhibit increased vulnerability in stressful environmental conditions. In this study, we assessed the differences in responses between young and aged animals to folic acid (FA)-induced...
Guo, Jie Marseglia, Anna Shang, Ying Dove, Abigail Grande, Giulia Fratiglioni, Laura Xu, Weili
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
The impact of late-life weight changes on incident dementia is unclear. We aimed to investigate the associations of body mass index (BMI) and weight changes with dementia and to explore the role of APOE ɛ4 in these associations. A total of 1 673 dementia-free participants aged ≥60 and older were followed for an initial 6 years to detect changes in ...
Alves, Francesca M Ayton, Scott Bush, Ashley I Lynch, Gordon S Koopman, René
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Sarcopenia is an age-related condition of slow, progressive loss of muscle mass and strength, which contributes to frailty, increased risk of hospitalization and mortality, and increased health care costs. The incidence of sarcopenia is predicted to increase to >200 million affected older adults worldwide over the next 40 years, highlighting the ur...
Giacconi, Robertina D'Aquila, Patrizia Malavolta, Marco Piacenza, Francesco Bürkle, Alexander Villanueva, María Moreno Dollé, Martijn E T Jansen, Eugène Grune, Tilman Gonos, Efstathios S
...
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Aging and age-related diseases have been linked to microbial dysbiosis with changes in blood bacterial DNA concentration. This condition may promote chronic low-grade inflammation, which can be further aggravated by antioxidant nutrient deficiency. Low plasma carotenoids are associated with an increased risk of inflammation and cellular damage and ...
Giannos, Panagiotis Prokopidis, Konstantinos Church, David D Kirk, Ben Morgan, Paul T Lochlainn, Mary Ni Macpherson, Helen Woods, David R Ispoglou, Theocharis
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Age-associated cognitive decline may be influenced by testosterone status. However, studies evaluating the impact of bioavailable testosterone, the active, free testosterone, on cognitive function are scarce. Our study determined the relationship between calculated bioavailable testosterone and cognitive performance in older men. We used data from ...
Pencina, Karol M Lavu, Siva Dos Santos, Marcello Beleva, Yusnie M Cheng, Ming Livingston, David Bhasin, Shalender
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Nicotinamide adenine dinucleotide (NAD) precursors, nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR) extend healthspan and ameliorate some age-related conditions in model organisms. However, early-phase trials of NAD precursors have yielded varying results and their pharmacokinetics remain incompletely understood. Here, we report th...
Nakazawa, Noriko Kusama, Taro Cooray, Upul Yamamoto, Takafumi Kiuchi, Sakura Abbas, Hazem Yamamoto, Tatsuo Kondo, Katsunori Osaka, Ken Aida, Jun
...
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Oral diseases are preventable and modifiable, but highly prevalent, and cause worse oral status. Particularly, tooth loss has increased in aging societies. However, studies on population-attributable risks of modifiable risk factors for mortality have neglected oral status. This study aimed to investigate the impact of modifiable risk factors on mo...
Zhang, Xuxi Lin, Lizi Sun, Xinying Lei, Xiaoyan Liu, Gordon G Raat, Hein Zeng, Yi
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
With the rapid population aging, the challenge to provide care for disabled older adults is becoming bigger. This study aims to develop the Disability Index (DI) to assess disability to indicate care needs, and we evaluated the reliability and validity of the DI among older adults aged 65-105. A total of 12 559 older adults (54.0% women; mean age =...
Ha, Junghee Kwak, Seyul Kim, Keun You Kim, Hyunjeong Cho, So Yeon Kim, Minae Lee, Jun-Young Kim, Eosu
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Adipokines such as leptin and adiponectin are associated with cognitive function. Although adiposity crucially affects adipokine levels, it remains unclear whether the relationship between adipokines and cognition is influenced by obesity. We enrolled 171 participants and divided them into participants with obesity and without obesity to explore th...
