Caballero, Francisco Félix Struijk, Ellen A Buño, Antonio Rodríguez-Artalejo, Fernando Lopez-Garcia, Esther
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Higher levels of ceramides have been linked to several chronic diseases; also there is emerging cross-sectional evidence that ceramides are associated with lower physical functioning. This research assessed for the first time the prospective relationship between ceramide species and impaired lower-extremity function (ILEF) in older adults. Case-con...
Azhar, Gohar Wei, Jeanne Y Schutzler, Scott E Coker, Karen Gibson, Regina V Kirby, Mitchell F Ferrando, Arny A Wolfe, Robert R
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
We have investigated the hypothesis that nutritional supplementation of the diet in low-physical-functioning older individuals with a specially formulated composition based on essential amino acids (EAAs) would improve physical function as compared to supplementation with the same amount of whey protein. A third group of comparable volunteers were ...
Santanasto, Adam J Cvejkus, Ryan K Wojczynski, Mary K Marron, Megan M Schupf, Nicole Christensen, Kaare Thyagarajan, Bharat Zmuda, Joseph M
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Circulating levels of procollagen type III N-terminal peptide (P3NP) may reflect increased fibrosis of skeletal muscle and other tissues with aging. Herein, we tested if P3NP was associated with baseline and 7-year change in physical function. Participants (n = 400) were from the Long Life Family Study, a study of exceptional familial longevity. Pl...
Koivunen, Kaisa Sillanpää, Elina Munukka, Matti Portegijs, Erja Rantanen, Taina
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Whether increased life expectancy is accompanied by increased functional capacity in older people at specific ages is unclear. We compared similar validated measures of maximal physical performance in 2 population-based older cohorts born and assessed 28 years apart. Participants in the first cohort were born in 1910 and 1914 and were assessed at a...
Di Bari, Mauro Carreras, Giulia Giordano, Antonella Degli Esposti, Luca Buda, Stefano Michelozzi, Paola Bernabei, Roberto Marchionni, Niccolò Balzi, Daniela
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
In randomized clinical trials, compared to Internal Medicine, admission to Geriatrics improved clinical outcomes of frail older patients accessing the Emergency Department (ED). Whether this advantage is maintained also in the "real world" is uncertain. We compared long-term survival of patients admitted to Geriatrics or Internal Medicine wards aft...
Baran, Szczepan W Lim, Maria A Do, Johnny P Stolyar, Polina Rabe, Mark D Schaevitz, Laura R Cadena, Samuel M
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
To understand the growing needs of an aging human population, there is demand for scalable and reproducible approaches to study animal models of aging and to test novel therapeutic interventions. We investigated the sensitivity and utility of a continuous monitoring platform and its digital biomarkers (motion, breathing rate, and wheel running) to ...
Stenholm, Sari Pulakka, Anna Leskinen, Tuija Pentti, Jaana Heinonen, Olli J Koster, Annemarie Vahtera, Jussi
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
This study aimed to identify accelerometer-measured daily physical activity patterns, and to examine how they associate with health-related physical fitness among aging workers. The study population consisted of 263 participants (mean age 62.4 years, SD 1.0) from the Finnish Retirement and Aging study, who used wrist-worn ActiGraph accelerometer fo...
Sherlala, Rehab A Kammerer, Candace M Kuipers, Allison L Wojczynski, Mary K Ukraintseva, Svetlana V Feitosa, Mary F Mengel-From, Jonas Zmuda, Joseph M Minster, Ryan L
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Serum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative correlations reported. However, the age ranges of the participants varied widely among these studies. Using data...
Wu, Yan Yan Thompson, Mika D Youkhana, Fadi Pirkle, Catherine M
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
This study investigated the association of lifestyle factors and polygenic risk scores (PGS), and their interaction, on type 2 diabetes mellitus (T2D). We examined data from the U.S. Health and Retirement Study, a prospective longitudinal cohort of adults aged 50 years and older, containing nationally representative samples of Black and White Ameri...
Enroth, Linda Raitanen, Jani Halonen, Pauliina Tiainen, Kristina Jylhä, Marja
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
It remains unclear whether increasing longevity is accompanied by a compression or expansion of poor health and disability. We examined trends of physical functioning and morbidity in a population aged 90 and older, and disease- and disability-free life expectancy (LE) at age 90 between 2001 and 2018 in Finland's third most populated city. We used ...
