Hornik, Chi D Bondi, Deborah S Greene, Nicole M Cober, M Petrea John, Barnabas
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Invasive candidiasis accounts for approximately 10% of nosocomial infections in preterm infants, with an incidence of 1% to 4% among neonatal intensive care unit (NICU) admissions and a mortality as high as 20% to 30%. These outcomes warrant improved treatment and prevention strategies for infants at highest risk. The Infectious Diseases Society of...
Zimmerman, Kanecia O Dallefeld, Samantha H Hornik, Christoph P Watt, Kevin M
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Sedatives and analgesics are often administered to critically ill children supported by extracorporeal membrane oxygenation (ECMO) to facilitate comfort and to decrease risks of life-threatening complications. Optimization of sedative and analgesic dosing is necessary to achieve desired therapeutic benefits and must consider interactions between th...
Gaffney, Kelly J Dahl, Elizabeth M Stanton, Michael P Jr Starek, Elizabeth Zembillas, Anthony S
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
The use of rapid rituximab infusion in certain pediatric populations has generally been regarded as safe. The safety of our institution's rapid rituximab protocol was evaluated. The primary end point was the number of and severity of adverse drug reactions. Secondary end points included a description of the patient population defined by the indicat...
Pasadyn, Selena R Giuliano, Kimberly LaBianca, Deanna Manos, Michael
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
The prevalence of attention-deficit/hyperactivity disorder (ADHD) is increasing and psychostimulants are the pharmacological standard of care. Patients benefit most when there is efficient titration to a stable dose of medication as defined by maintaining that same dose for 6 months. The aims of this study were to describe time to stable dose in a ...
Eaton, Aubrie Egelund, Tosha Ng, John
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Adequate hydration status prior to chemotherapy initiation prevents nephrotoxicity in patients receiving potentially nephrotoxic regimens. The purpose of this study was to evaluate the time to initiation of ifosfamide administration between patients receiving standard 6-hour pre-hydration versus 1-hour rapid pre-hydration. A retrospective study was...
Knoppert, David Rieder, Michael J
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Kolf, Meghan J McPherson, Christopher C Kniska, Kara S Luecke, Caitlyn M Lahart, Michael A Pineda, Jose A
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Although levetiracetam is used for the prevention of early Post-traumatic seizures (EPTS) after traumatic brain injury (TBI), limited data exist describing the incidence of seizures in pediatric patients receiving levetiracetam prophylaxis. The objective of this research is to evaluate the prevalence of EPTS in children given prophylactic levetirac...
Ridley, Kaden Condren, Michelle
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Elexacaftor-tezacaftor-ivacaftor is a newly approved triple-combination cystic fibrosis transmembrane conductance regulator (CFTR) modulating therapy that contains 2 correctors and a potentiator of the CFTR channel. Its labeled indication for use is for persons 12 years of age and older with at least 1 F508del mutation for the CFTR gene. This drug ...
Ziegler, Jason Chapman, Heather Rueth, Megan Hays, Annette Schriever, Christopher Tsaras, Geoffrey
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Extended-spectrum β-lactamases (ESBL) are produced mainly by members of the Enterobacteriaceae family and confer resistance to most β-lactam antibiotics. Because of limited treatment options, ESBL infections are typically more challenging to treat resulting in poor outcomes, increased complications, and mortality. Because ESBL-producing organisms a...
Linakis, Matthew W Rower, Joseph E Sorenson, Susan Reilly, Christopher A Lambert, Linda M Williams, Richard V Burch, Phillip T
Published in
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Growth failure following surgical palliation of complex congenital heart defects (CHDs) is a prognosticator of poor outcomes. Many strategies for improving weight gain have been implemented in this population, with limited success. We recently described the potential of the anabolic steroid oxandrolone to improve weight gain following surgical repa...
