Alrayes, Nuha Aziz, Abdul Ullah, Farman Ishfaq, Muhammad Jelani, Musharraf Wali, Abdul
Published in
The journal of gene medicine
Syndactyly is a clinical feature of split-hand foot malformation (SHFM), ectodermal-dysplasia-syndactyly (EDSS1), and Cenani-Lenz syndactyly syndromes (CLSS). In EDSS1 only cutaneous syndactyly is observed with sparse hair, abnormal nails and dentition. While in SHFM bony syndactyly may vary from hypoplasia of one phalanx to aplasia of central digi...
Chiang, Shang-Lun Nithiyanantham, Srinivasan Velmurugan, Bharath Kumar Tu, Hung-Pin Lee, Chien-Hung Ko, Ying-Chin
Published in
The journal of gene medicine
Cigarette smoking in women is raising a public health problem. The X-linked monoamine oxidase A (MAOA) was considered as a susceptibility gene to substance abuse of tobacco, but the evolutionary effect of MAOA may lead to a positive or negative association between genetic variations and smoking development among study regions. Based on linkage dise...
das Chagas, Pablo Ferreira Baroni, Mirella Brassesco, María Sol Tone, Luiz Gonzaga
Published in
The journal of gene medicine
Musashi is an evolutionarily conserved family of RNA-binding proteins (RBP) that regulates cell fate decisions during embryonic development and plays key roles for the maintenance of self-renewal and differentiation of stem cells and adult tissues. More recently, several studies have shown that any dysregulation of MSI1 and MSI2 can lead to cellula...
Saravani, Mohsen Rokni, Mohsen Mehrbani, Mehrzad Amirkhosravi, Arian Faramarz, Sanaz Fatemi, Iman Esmaeili Tarzi, Mojdeh Nematollahi, Mohammad Hadi
Published in
The journal of gene medicine
Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheets destruction. Hypoxia-inducible factor 1 (HIF-1) has several roles in cells like inducing inflammation and angiogenesis. Recently, several lines of evidence have indicated the role of hypoxia response and HIF-1 signaling pathway in the autoimmune disease like MS. The aims o...
Wu, Tao Bai, Hao Zhao, Zhenzhen Wang, Minjin Hu, Xuejiao Jiao, Lin Wu, Qian Liu, Tangyuheng Zhang, Chunying Chen, Hao
...
Published in
The journal of gene medicine
Antituberculosis drug-induced liver injury (ATDILI) is increasing globally and, hence, it is crucial to predict its risk in the clinical management of antituberculosis therapy. As a major antioxidant, superoxide dismutase (SOD) is mainly responsible for providing defence against oxidative stress, which is involved in ATDILI. The present study aimed...
Pasha, Heba F Mohamed, Randa H Toam, Mostafa M Yehia, Ahmed M
Published in
The journal of gene medicine
Adipokines produced by adipose tissue are directly linked to obesity and may contribute to the pathogenesis of cancer. We hypothesized that genetic and epigenetic modifications in the adiponectin (ADIPOQ) gene and their impact on serum ADIPOQ levels may participate in increasing breast cancer (BC) risk. The present study aimed to investigate ADIPOQ...
Pulati, Nuerbieke Zhang, Zegao Gulimilamu, Aireti Qi, Xiaoli Yang, Jie
Published in
The journal of gene medicine
The early diagnosis of cervical cancer is difficult, resulting in an unsatisfactory prognosis. The present study aimed to explore the expression of HPV16-related microRNAs (miRNAs) in the serum of Uygur cervical cancer in Sinkiang and analyze the miRNAs showing different expression. The serum of 30 HPV16 positive (HPV16Pos) and 30 negative patients...
Zhang, Ning Chen, Huimei Jia, Jian Ye, Xiaoman Ding, Haixia Zhan, Yiyang
Published in
The journal of gene medicine
The CYP17A1 gene has been identified to associate with hypertension in Chinese population. However, the association between CYP17A1 polymorphisms and hypertension-related factors is unclear. The present study aimed to investigate the relation between CYP17A1 single nucleotide polymorphisms (SNPs) and serum lipid profiles. In total, 1350 participant...
Hu, Rong Zhu, Zongming
Published in
The journal of gene medicine
Long non-coding RNA (lncRNA) is reported to be involved in multiple biological processes in numerous human tumors. Furthermore, an increasing number of studies have confirmed the involvement of lncRNA in the initiation and development of human cancers, including cervical cancer (CC). The present study explored the potential role of lncRNA glypican ...
Wang, Haili Ding, Shenggang Zhang, Ze Wang, Longhai You, Yezi
Published in
The journal of gene medicine
Micelles have demonstrated an excellent ability to deliver several different types of therapeutic agents, including chemotherapy drugs, proteins, small-interfering RNA and DNA, into tumor cells. Cationic micelles, comprising self-assemblies of amphiphilic cationic polymers, have exhibited tremendous promise with respect to the delivery of therapy g...
