Li, Wei-Yu Shi, Tian-Shun Huang, Jie Chen, Yan-Mei Guan, Wei Jiang, Bo Wang, Cheng-Niu
Published in
The international journal of neuropsychopharmacology
Although thought of as a multimodal-acting antidepressant targeting the serotonin system, more molecules are being shown to participate in the antidepressant mechanism of vortioxetine. A previous report has shown that vortioxetine administration enhanced the expression of rapamycin complex 1 (mTORC1) in neurons. It has been well demonstrated that m...
Singh, Priyanka Srivastava, Ankit Guin, Debleena Thakran, Sarita Yadav, Jyoti Chandna, Puneet Sood, Mamta Chadda, Rakesh Kumar Kukreti, Ritushree
Published in
The international journal of neuropsychopharmacology
The clinical heterogeneity in major depressive disorder (MDD), variable treatment response, and conflicting findings limit the ability of genomics toward the discovery of evidence-based diagnosis and treatment regimen. This study attempts to curate all genetic association findings to evaluate potential variants for clinical translation. We systemat...
Cheng, Ziqian Zhang, Chaohe Zhao, Fangyi Piao, Jingjing Cui, Ranji Li, Bingjin
Published in
The international journal of neuropsychopharmacology
Previous studies have shown that estrogen and acute fasting for 9 hours have antidepressant-like effects by reducing immobility time in the forced swimming test. Estrogen and acute fasting share a common regulatory gene, Rasd2. RASD2 regulates dopamine D2 receptor (DRD2) transmission, but the role of Rasd2 in the DRD2-mediated antidepressant-like e...
Gattuso, James J Perkins, Daniel Ruffell, Simon Lawrence, Andrew J Hoyer, Daniel Jacobson, Laura H Timmermann, Christopher Castle, David Rossell, Susan L Downey, Luke A
...
Published in
The international journal of neuropsychopharmacology
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well as profound psychological and mystical experiences. A grouping of interconnected brain regions characterized by increased temporal coherence at rest have been termed the Default Mode Network (DMN). The DMN has been the focus of numerous studies assessing its ...
Galaj, Ewa Barrera, Eddy D Lynch, Olivia L Diodati, Rachel Thomas, Ashley Schneider, Piper Lenhard, Hayley Vashisht, Apoorva Ranaldi, Robert
Published in
The international journal of neuropsychopharmacology
Reward-related learning, where animals form associations between rewards and stimuli (i.e., conditioned stimuli [CS]) that predict or accompany those rewards, is an essential adaptive function for survival. In this study, we investigated the mechanisms underlying the acquisition and performance of conditioned approach learning with a focus on the r...
Russell, Samantha E Wrobel, Anna L Skvarc, David Kavanagh, Bianca E Ashton, Melanie M Dean, Olivia M Berk, Michael Turner, Alyna
Published in
The international journal of neuropsychopharmacology
The prevalence of posttraumatic stress disorder (PTSD) co-occurring in people with bipolar disorder (BD) is high. People with BD and PTSD may experience different outcomes and quality of life after pharmacologic treatment than those with BD alone. This review systematically explores the impact of PTSD on pharmacologic treatment outcomes for adults ...
Hou, Xueqin Rong, Cuiping Zhang, Qiwei Song, Shuangshuang Cong, Yifan Zhang, Han-Ting
Published in
The international journal of neuropsychopharmacology
Alcohol abuse is 1 of the most significant public health problems in the world. Chronic, excessive alcohol consumption not only causes alcohol use disorder (AUD) but also changes the gut and lung microbiota, including bacterial and nonbacterial types. Both types of microbiota can release toxins, further damaging the gastrointestinal and respiratory...
Gruzman, Rebecca Hartling, Corinna Domke, Ann-Kathrin Stippl, Anna Carstens, Luisa Bajbouj, Malek Gärtner, Matti Grimm, Simone
Published in
The international journal of neuropsychopharmacology
Electroconvulsive therapy (ECT) is an effective treatment for patients suffering from depression. Yet the exact neurobiological mechanisms underlying the efficacy of ECT and indicators of who might respond best to it remain to be elucidated. Identifying neural markers that can inform about an individual's response to ECT would enable more optimal t...
Su, Liang Zhang, Yi Jia, Yuping Sun, Junfeng Mellor, David Yuan, Ti-Fei Xu, Yifeng
Published in
The international journal of neuropsychopharmacology
Electroconvulsive therapy (ECT) is an effective therapy for major depressive disorder (MDD) patients. However, few clinical predictors are available to predict the treatment outcome. This study aimed to characterize the response trajectories of MDD patients undergoing ECT treatment and to identify potential clinical and demographic predictors for c...
Wang, Tzu-Yun Lu, Ru-Band Lee, Sheng-Yu Chang, Yun-Hsuan Chen, Shiou-Lan Tsai, Tsung-Yu Tseng, Huai-Hsuan Chen, Po See Chen, Kao Chin Yang, Yen Kuang
...
Published in
The international journal of neuropsychopharmacology
Long-term opioid and amphetamine-type stimulants (ATS) abuse may affect immunological function and impair executive function. We aimed to determine whether biomarkers of inflammation and executive function were associated with substance use in individuals with opioid use disorder (OUD) and ATS use disorder (ATSUD). The interactions between these bi...
