Guo, Jingning Shi, Yanping Wang, Yujun Athari, Seyyed Shamsadin Chen, Tao
Published in
The clinical respiratory journal
Allergic asthma is an important respiratory system problem characterized by airway inflammation, breathlessness, and bronchoconstriction. Allergic asthma and its outcomes are triggered by type 2 allergic immune responses. Tectorigenin is a methoxy-isoflavone with anti-inflammatory effects. In this study, we investigated the effects of tectorigenin ...
Zhang, Lin Chen, Wei Wei, Hongtao Yu, Junxian
Published in
The clinical respiratory journal
Previous studies have shown that immune checkpoint inhibitors can improve the survival of patients with advanced non-small cell lung cancer with KRAS mutations; however, there is a lack of comparisons between treatment regimens associated with immune checkpoint inhibitors, and our study aims to compare several treatment parties to find a more effec...
Wang, Kang Hu, Xueting Chen, Yufang Yi, Xinglin Han, Xianfeng Zhu, Duan Zhu, Bingjing Luo, Hu
Published in
The clinical respiratory journal
This study was to investigate the diagnostic value of percutaneous closed pleural brushing (CPBR) followed by cell block technique for malignant pleural effusion (MPE) and the predictive efficacy of pleural fluid carcinoembryonic antigen (CEA) for epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma patients with MPE. All patien...
Guo, Cuiyan Zhang, Qi Hu, Yan Huang, Junfang Wang, Shixuan Wang, Guangfa
Published in
The clinical respiratory journal
The objective of this study is to study the adjunct role of combining DNA aneuploidy analysis with radial endobronchial ultrasound (R-EBUS)-guided sampling for diagnosis of peripheral lung lesions (PPLs). A single-center prospective study was conducted in patients undergoing R-EBUS-guided sampling for PPLs. DNA image cytometry (DNA-ICM) was used to...
Wang, Liping Zhang, Hui Gu, Xinliang Wang, Ying
Published in
The clinical respiratory journal
Regulator of G protein signalling 1 (RGS1) closely regulates malignant phenotypes and tumour immunity in several cancers, while its clinical value in nonsmall cell lung cancer (NSCLC) is by far rarely reported. Consequently, this study aimed to explore the linkage of blood RGS1 with clinical features and prognosis in surgical NSCLC patients. Two-hu...
Huang, Ya-Jie He, Jian-Kun Duan, Xiaoyang Hou, Ran Shi, Jian
Published in
The clinical respiratory journal
The dominant subclass of non-small-cell lung cancer (NSCLC) is lung adenocarcinoma (LUAD). The tumor microenvironment (TME) is a crucial feature of carcinogenesis and progression in LUAD. Furthermore, immune and stromal components of TME are crucial factors to investigating and curing LUAD. Thus, the study assessed the value of TME-related genes fo...
Huang, Qiong Li, Yan Li, Chenduo Zhang, Xin Du, Xiaonan Chen, Yan Corrigan, Chris J Wang, Wei Ying, Sun
Published in
The clinical respiratory journal
Many asthmatic patients are exposed to cigarette smoke actively or passively, which contributes to asthma exacerbation and poor control. This study is to explore the effects of cigarette smoke on pathological changes in murine surrogate of asthma. C57BL/6 mice were sensitised and challenged with ovalbumin (OVA) to establish a surrogate of asthma an...
Fahey, Aisling C O'Connell, Martina Cornally, Nicola Saab, Mohamad M
Published in
The clinical respiratory journal
Chronic obstructive pulmonary disease can lead to acute hypercapnic respiratory failure (AHRF), often treated using noninvasive ventilation (NIV). Emerging research suggests the potential utility of high flow nasal cannula (HFNC) for AHRF. This systematic review and meta-analysis aimed to determine the effect of HFNC versus NIV on AHRF management. ...
Xu, Qian Lu, Tingting Song, Zhongyang Zhu, Peng Wu, Yana Zhang, Lumei Yang, Kehu Zhang, Zhiming
Published in
The clinical respiratory journal
Montelukast is a highly selective and specific cysteinyl leukotriene receptor antagonist used in the treatment of asthma. Whether montelukast as adjuvant therapy can significantly and safely treat adults with cough variant asthma (CVA) remains inconclusive. This meta-analysis systematically evaluated the efficacy and safety of montelukast as an adj...
Liu, Jie Pang, Feng Huang, Xiaofeng Zhang, Xiangmin Lin, Minmin Deng, Wenmin Liu, Tianrun Long, Zhen
Published in
The clinical respiratory journal
Many scales are designed to screen for obstructive sleep apnoea-hypopnoea syndrome (OSAHS); however, there is a lack of an efficiently and easily diagnostic tool, especially for Chinese. Therefore, we conduct a cross-sectional study in China to develop and validate an efficient and simple clinical diagnostic model to help screen patients at risk of...
