2018 Wakley Prize Essay: something understood
Published in The Lancet
Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patie...
...Published in The Lancet
BACKGROUND: Hepatitis C virus (HCV) genotype 4 accounts for about 13% of global HCV infections. Because interferon-containing treatments for genotype 4 infection have low efficacy and poor tolerability, an unmet need exists for effective all-oral regimens. We examined the efficacy and safety of an all-oral interferon-free regimen of ombitasvir, an...
20 years of the ICRC Code of Conduct for Disaster Relief: what do we need to improve?
Published in The Lancet
The Code of Conduct for Disaster Relief of the International Committee of the Red Cross (ICRC) was written for use by the International Red Cross, Red Crescent Movements, and non-governmental organisations (NGOs) working in disaster relief. The code was published just after the Rwanda genocide in April, 1994.1 The code consists of a purpose and fou...
20 years of the ICRC Code of Conduct for Disaster Relief: what do we need to improve?
Published in The Lancet
Diagnostics and Treatment of Cryoglobulinaemia: It Takes Two to Tango
Published in Clinical Reviews in Allergy & Immunology
Cryoglobulins are immunoglobulins that reversibly precipitate in the cold. They come in different flavours and, as such, are differentially associated with lymphoproliferative diseases (type I), or systemic autoimmune diseases, and/or infectious diseases (type II/III). The clinical manifestations of cryoglobulinaemia result from either hyper-viscos...
Defining success in neoadjuvant breast cancer trials
Published in The Lancet
Myelodysplastic syndromes
Published in The Lancet
Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid leukaemia in a third of patients. 15% of cases occur after chemotherapy or radiotherapy for a previous cancer; the syndromes are most common in elderly people. The pathophysiolog...
Modifying disability in progressive multiple sclerosis
Published in The Lancet
Improving access to vaccines through tiered pricing
Published in The Lancet
Cholangiocarcinoma
Published in The Lancet
Cholangiocarcinoma represents a diverse group of epithelial cancers united by late diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are undertaken for cholangiocarcinomas of different anatomical locations (intrahepatic, perihilar, and distal). Mixed hepatocellular cholangiocarcinomas have emerged as a distinct subtype of ...
