Published in The Journal of physiology
Ipsilateral-projecting corticobulbar pathways, originating primarily from secondary motor areas, innervate the proximal and even distal portions, but branch more extensively at the spinal cord It is currently unclear to what extent these ipsilateral secondary motor areas and subsequent cortical projections may contribute to hand function following ...
Published in The Journal of physiology
Goal-directed arm movements can be adjusted at short latency to target shifts. We tested whether similar adjustments are present during walking on a treadmill with shifting stepping targets. Participants responded at short latency with an adequate gain to small shifts of the stepping targets. Movements of the feet during walking are controlled in a...
Published in The Journal of physiology
The spinal cord is an important contributor to motor learning It remains unclear whether short-term spinal cord adaptations are general or task-specific Immediately after task acquisition, neural adaptations were not specific to the trained task (i.e. were general) Twenty-four hours after acquisition, neural adaptations appeared to be task-specific...
Published in The Journal of physiology
Skeletal muscle energy requirements increase at birth but little is known regarding the development of mitochondria that provide most of the cellular energy as ATP. Thyroid hormones are known regulators of adult metabolism and are important in driving several aspects of fetal development, including muscle fibre differentiation. Mitochondrial densit...
Published in The Journal of physiology
Published in The Journal of physiology
Published in The Journal of physiology
Respiratory sinus arrhythmia is physiological pacing of the heart that disappears in cardiovascular disease and is associated with poor cardiac prognosis. In heart failure, cardiac pacing has little, if any, variation in rate at rest. We proposed that reinstatement of respiratory sinus arrhythmia would improve cardiac function in rats with heart fa...
Published in The Journal of physiology
Exercise in patients with hypertension can be accompanied by an abnormal cardiovascular response that includes attenuated blood flow and an augmented pressor response. Endothelin-1, a very potent vasoconstrictor, is a key modulator of blood flow and pressure during in health and has been implicated as a potential cause of the dysfunction in hyperte...
Published in The Journal of physiology
For individuals showing suboptimal adaptations to resistance training, manipulation of training volume is a potential measure to facilitate responses. This remains unexplored. Here, 34 untrained individuals performed contralateral resistance training with moderate and low volume for 12 weeks. Moderate volume led to larger increases in muscle cross-...
Published in The Journal of physiology
Much is known about myogenic mechanisms in circular muscle (CM) in the GI tract, but less is known about longitudinal muscle (LM). Two Ca2+ signalling behaviours occur in LM, localized intracellular waves not causing contractions and intercellular waves leading to excitation-contraction (E-C) coupling. An Ano1 channel antagonist inhibited intercell...
