Pertici, Irene Taft, Manuel H Greve, Johannes N Fedorov, Roman Caremani, Marco Manstein, Dietmar J
Published in
The Journal of physiology
Direct binding of rumenic acid to the cardiac myosin-2 motor domain increases the release rate for orthophosphate and increases the Ca2+ responsiveness of cardiac muscle at low load. Physiological cellular concentrations of rumenic acid affect the ATP turnover rates of the super-relaxed and disordered relaxed states of β-cardiac myosin, leading to ...
Solomon, Tanya Filipovska, Aleksandra Hool, Livia Viola, Helena
Published in
The Journal of physiology
Sarcomeric gene mutations are associated with the development of hypertrophic cardiomyopathy (HCM). Current drug therapeutics for HCM patients are effective in relieving symptoms, but do not prevent or reverse disease progression. Moreover, due to heterogeneity in the clinical manifestations of the disease, patients experience variable outcomes in ...
Wilson, Zachary T Jiang, Min Geng, Jing Kaur, Sukhleen Workman, Samuel W Hao, Jon Bernas, Tytus Tseng, Gea-Ny
Published in
The Journal of physiology
In adult ventricular myocytes, the slow delayed rectifier (IKs ) channels are distributed on the surface sarcolemma, not t-tubules. In adult ventricular myocytes, KCNQ1 and KCNE1 have distinct cell surface and cytoplasmic pools. KCNQ1 and KCNE1 traffic from the endoplasmic reticulum to the plasma membrane by separate routes, and assemble into IKs c...
Figueiredo, Vandré C Wen, Yuan Alkner, Björn Fernandez-Gonzalo, Rodrigo Norrbom, Jessica Vechetti, Ivan J Jr Valentino, Taylor Mobley, C Brooks Zentner, Gabriel E Peterson, Charlotte A
...
Published in
The Journal of physiology
Ribosome biogenesis and MYC transcription are associated with acute resistance exercise (RE) and are distinct from endurance exercise in human skeletal muscle throughout a 24 h time course of recovery. A PCR-based method for relative ribosomal DNA (rDNA) copy number estimation was validated by whole genome sequencing and revealed that rDNA dosage i...
Sato, Daisuke Uchinoumi, Hitoshi Bers, Donald M
Published in
The Journal of physiology
Increasing sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump activity enhances sarcoplasmic reticulum calcium (Ca) load, which increases both ryanodine receptor opening and driving force of Ca release flux. Both of these effects promote Ca spark formation and wave propagation. However, increasing SERCA activity also accelerates local c...
Philp, Ashleigh M Saner, Nicholas J Lazarou, Michael Ganley, Ian G Philp, Andrew
Published in
The Journal of physiology
Mitochondria are dynamic organelles, intricately designed to meet cellular energy requirements. To accommodate alterations in energy demand, mitochondria have a high degree of plasticity, changing in response to transient activation of numerous stress-related pathways. This adaptive response is particularly relevant in highly metabolic tissues such...
Douard, Matthieu
Published in
The Journal of physiology
Cilvik, Sarah N Wesolowski, Stephanie R Anthony, Russ V Brown, Laura D Rozance, Paul J
Published in
The Journal of physiology
Fetal glucagon concentrations are elevated in the setting of placental insufficiency, hypoxia and elevated stress hormones. Chronically elevated glucagon concentrations in the adult result in profound decreases in amino acid concentrations and lean body mass. Experimental elevation of fetal glucagon concentrations in a late-gestation pregnant sheep...
Gatford, Kathryn L
Published in
The Journal of physiology
Laine, Christopher M Cohn, Brian A Valero-Cuevas, Francisco J
Published in
The Journal of physiology
It is theorized that the nervous system controls groups of muscles together as functional units, or 'synergies', resulting in correlated electromyographic (EMG) signals among muscles. However, such correlation does not necessarily imply group-level neural control. Oscillatory synchronization (coherence) among EMG signals implies neural coupling, bu...
