Zhu, Mengye Idikuda, Vinay Kumar Wang, Jianbing Wei, Fusheng Kumar, Virang Shah, Nikhil Waite, Christopher B Liu, Qinglian Zhou, Lei
Published in
The Journal of physiology
SHANK3 is a scaffolding protein that is highly enriched in excitatory synapses. Mutations in the SHANK3 gene have been linked to neuropsychiatric disorders especially the autism spectrum disorders. SHANK3 deficiency is known to cause impairments in synaptic transmission, but its effects on basic neuronal electrical properties that are more localize...
Wei, R Lunn, S E Tam, R Gust, S L Classen, B Kerr, P M Plane, F
Published in
The Journal of physiology
Constriction of isolated resistance arteries in response to α1 -adrenoceptor agonists is limited by reciprocal engagement of inhibitory endothelial mechanisms via myoendothelial feedback. In the current model of feedback, agonist stimulation of smooth muscle cells results in localized InsP3 -dependent Ca2+ transients that activate endothelial IKCa ...
Chiou, Shin-Yi Hurry, Madeleine Reed, Thomas Quek, Jing Xiao Strutton, Paul H
Published in
The Journal of physiology
Voluntary limb movements are associated with increases in trunk muscle activity, some of which occur within a time window considered too fast to be induced by sensory feedback; these increases are termed anticipatory postural adjustments (APAs). Although it is known that the function of APAs is to maintain postural stability in response to perturba...
Nichols, Joshua Bjorklund, George Reed Newbern, Jason Anderson, Trent
Published in
The Journal of physiology
Paediatric traumatic brain injury (TBI) is a leading cause of death and disability in children. Traditionally, ongoing neurodevelopment and neuroplasticity have been considered to confer children with an advantage following TBI. However, recent findings indicate that the paediatric brain may be more sensitive to brain injury. Inhibitory interneuron...
Lau, Carus Hunter, Mark J Stewart, Alastair Perozo, Eduardo Vandenberg, Jamie I
Published in
The Journal of physiology
The tightly regulated opening and closure of ion channels underlies the electrical signals that are vital for a wide range of physiological processes. Two decades ago the first atomic level view of ion channel structures led to a detailed understanding of ion selectivity and conduction. In recent years, spectacular developments in the field of cryo...
Koos, Björn Christmann, Jens Plettenberg, Sandra Käding, Domenic Becker, Julia Keteku, Melody Klein, Christian Imtiaz, Sarah Janning, Petra Bastiaens, Philippe I H
...
Published in
The Journal of physiology
Hypertonicity-induced cation channels (HICCs) are a substantial element in the regulatory volume increase (RVI) of osmotically shrunken cells. Under isotonic conditions, they are key effectors in the volume gain preceding proliferation; HICC repression, in turn, significantly increases apoptosis rates. Despite these fundamental roles of HICCs in ce...
Parkes, M J Clutton-Brock, T H
Published in
The Journal of physiology
Pham, Toan Nisbet, Linley Taberner, Andrew Loiselle, Denis Han, June-Chiew
Published in
The Journal of physiology
Pulmonary arterial hypertension (PAH) greatly increases the afterload on the right ventricle (RV), triggering RV hypertrophy, which progressively leads to RV failure. In contrast, the disease reduces the passive filling pressure of the left ventricle (LV), resulting in LV atrophy. We investigated whether these distinct structural and functional con...
Song, Seungmoon Geyer, Hartmut
Published in
The Journal of physiology
Healthy elderly people walk slower and energetically less efficiently than young adults. This decline in walking performance lowers the quality of life for a growing ageing population, and understanding its physiological origin is critical for devising interventions that can delay or revert it. However, the origin of the decline in walking performa...
Puppala, Sobha Li, Cun Glenn, Jeremy P Saxena, Romil Gawrieh, Samer Quinn, Amy Palarczyk, Jennifer Dick, Edward J Jr Nathanielsz, Peter W Cox, Laura A
...
Published in
The Journal of physiology
Maternal obesity (MO) increases offspring cardiometabolic disease risk. Altered fetal liver development in response to the challenge of MO has metabolic consequences underlying adverse offspring life-course health outcomes. Little is known about molecular pathways and potential epigenetic changes regulating primate fetal liver responses to MO. We h...
