Xiao, Hongyu Fang, Zhi He, Xueling Ding, Ping Cao, Yongkai Chan, Shamyuen Hou, Shaozhen Liang, Jian
Published in
The Journal of pharmacy and pharmacology
To explore the effect of recombinant LZ-8 (rLZ-8) on streptozocin (STZ)-induced diabetic rats and further illustrate its underlying mechanism. Rats were intraperitoneally injected with single-dose STZ 50 mg/kg for induction of type 1 diabetes (T1D), and then, the diabetic rats were treated with rLZ-8 for 3 months. The clinical symptoms, fasting blo...
Tiang, Ning Ahad, Mohamad Anuar Murugaiyah, Vikneswaran Hassan, Zurina
Published in
The Journal of pharmacy and pharmacology
Xanthones isolated from the pericarp of Garcinia mangostana has been reported to exhibit neuroprotective effect. In this study, the effect of xanthone-enriched fraction of Garcinia mangostana (XEFGM) and α-mangostin (α-MG) were investigated on cognitive functions of the chronic cerebral hypoperfusion (CCH) rats. HPLC analysis revealed that XEFGM co...
Liu, Ping Zhu, Lei Zhou, Limei Bai, Xinyu
Published in
The Journal of pharmacy and pharmacology
To determine whether ecto-5'-nucleotidase (e5NT) contributes to the release of adenosine and uridine and whether is establishes the role of e5NT in acute restraint stress-induced depression and anxiety-like behaviours in mice. Acute restraint stress was induced to detect the level of nucleoside in the hippocampus. Mouse hippocampal brain proteins w...
Wang, Wei Yue, Ru-Feng Jin, Zhen He, Li-Min Shen, Rong Du, Dan Tang, You-Zhi
Published in
The Journal of pharmacy and pharmacology
Chamomile has long been used as a medicinal plant due to its antioxidative and anti-inflammatory activity. Apigenin-7-O-glucoside (AG) is one of the major ethanol extract components from chamomile; however, the underlying mechanism remains unclear. In this study, the antioxidant potential and the anti-inflammatory activities of AG were analysed and...
Abdelkader, Ayat Fathi, Heba A Hamad, Mostafa A Elsabahy, Mahmoud
Published in
The Journal of pharmacy and pharmacology
Drug incompatibilities may compromise the safety and effectiveness of combined drugs and result in mild-to-serious clinical complications, such as catheter obstruction, loss of drug efficacy, formation of toxic derivatives and embolism. Various preventive strategies have been implemented to overcome drug incompatibilities with limited success. This...
Singh, Shareen Singh, Thakur Gurjeet Mahajan, Kriti Dhiman, Sonia
Published in
The Journal of pharmacy and pharmacology
Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self-neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self-epitop...
Sánchez-Recillas, Amanda Navarrete-Vázquez, Gabriel Hidalgo-Figueroa, Sergio Bonilla-Hernández, Marcos Ortiz-Andrade, Rolffy Ibarra-Barajas, Maximiliano Yáñez-Pérez, Víctor Sánchez-Salgado, Juan Carlos
Published in
The Journal of pharmacy and pharmacology
This work describes the vasorelaxant and antihypertensive effects and the mechanism of action on vascular smooth muscle cells of Nibethione, a synthetic thiazolidinedione derivative. Additionally, evidence of its cytotoxicity is assessed. Nibethione (NB) was synthesized, and its vasorelaxant effect and mechanism of action were assessed through ex v...
Wang, Chao Yang, Yong-Hong Zhou, Liang Ding, Xin-Li Meng, Ying-Chun Han, Ke
Published in
The Journal of pharmacy and pharmacology
Curcumin presents some therapeutic effects including anti-cancer and anti-inflammation. Herein, we centred on the functional role of curcumin in cerebral ischaemia injury and its potential molecular mechanisms. Microarray analysis was used for excavating crucial genes in cerebral ischaemia. PC12 cells were subjected to oxygen-glucose deprivation an...
Almurjan, Aminah Macfarlane, Hannah Badhan, Raj K S
Published in
The Journal of pharmacy and pharmacology
Paroxetine has been demonstrated to undergo gestation-related reductions in plasma concentrations, to an extent which is dictated by the polymorphic state of CYP 2D6. However, knowledge of appropriate dose titrations is lacking. A pharmacokinetic modelling approach was applied to examine gestational changes in trough plasma concentrations for CYP 2...
Shi, Meiyun Xu, Mengyao Yin, Lei
Published in
The Journal of pharmacy and pharmacology
The purpose of this study is to reveal the pharmacokinetic profiles of astilbin with various doses in rats and investigate the oral absolute bioavailability and tissue distribution of astilbin after oral administration. Wistar rats were orally administered astilbin 12, 24 mg/kg and intravenous administered astilbin 6 mg/kg randomly. The concentrati...
