Xiao, Hongyu Fang, Zhi He, Xueling Ding, Ping Cao, Yongkai Chan, Shamyuen Hou, Shaozhen Liang, Jian
Published in
The Journal of pharmacy and pharmacology
To explore the effect of recombinant LZ-8 (rLZ-8) on streptozocin (STZ)-induced diabetic rats and further illustrate its underlying mechanism. Rats were intraperitoneally injected with single-dose STZ 50 mg/kg for induction of type 1 diabetes (T1D), and then, the diabetic rats were treated with rLZ-8 for 3 months. The clinical symptoms, fasting blo...
Tiang, Ning Ahad, Mohamad Anuar Murugaiyah, Vikneswaran Hassan, Zurina
Published in
The Journal of pharmacy and pharmacology
Xanthones isolated from the pericarp of Garcinia mangostana has been reported to exhibit neuroprotective effect. In this study, the effect of xanthone-enriched fraction of Garcinia mangostana (XEFGM) and α-mangostin (α-MG) were investigated on cognitive functions of the chronic cerebral hypoperfusion (CCH) rats. HPLC analysis revealed that XEFGM co...
Liu, Ping Zhu, Lei Zhou, Limei Bai, Xinyu
Published in
The Journal of pharmacy and pharmacology
To determine whether ecto-5'-nucleotidase (e5NT) contributes to the release of adenosine and uridine and whether is establishes the role of e5NT in acute restraint stress-induced depression and anxiety-like behaviours in mice. Acute restraint stress was induced to detect the level of nucleoside in the hippocampus. Mouse hippocampal brain proteins w...
Wang, Wei Yue, Ru-Feng Jin, Zhen He, Li-Min Shen, Rong Du, Dan Tang, You-Zhi
Published in
The Journal of pharmacy and pharmacology
Chamomile has long been used as a medicinal plant due to its antioxidative and anti-inflammatory activity. Apigenin-7-O-glucoside (AG) is one of the major ethanol extract components from chamomile; however, the underlying mechanism remains unclear. In this study, the antioxidant potential and the anti-inflammatory activities of AG were analysed and...
Enoki, Yuki Suzuki, Norihiro Ito, Motoyasu Uchiyama, Eri Kishi, Nagomi Ito, Chihiro Kitahiro, Yuki Sakamoto, Kazuki Taguchi, Kazuaki Yokoyama, Yuta
...
Published in
The Journal of pharmacy and pharmacology
Raltegravir (RAL) that can form chelates with multivalent metal cations shows lateral interactions with multivalent metal cation and polycationic polymer. We investigated the interactions of RAL with multivalent metal cation preparations, Al(OH)3 and LaCO3 , and polycationic polymer preparations, bixalomer (Bxl) and sevelamer (Svl). Immediately bef...
Abdelkader, Ayat Fathi, Heba A Hamad, Mostafa A Elsabahy, Mahmoud
Published in
The Journal of pharmacy and pharmacology
Drug incompatibilities may compromise the safety and effectiveness of combined drugs and result in mild-to-serious clinical complications, such as catheter obstruction, loss of drug efficacy, formation of toxic derivatives and embolism. Various preventive strategies have been implemented to overcome drug incompatibilities with limited success. This...
Singh, Shareen Singh, Thakur Gurjeet Mahajan, Kriti Dhiman, Sonia
Published in
The Journal of pharmacy and pharmacology
Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self-neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self-epitop...
Kometsi, Lereko Govender, Khmera Mofo Mato, Edith P Hurchund, Rajendraparsad Owira, Peter M O
Published in
The Journal of pharmacy and pharmacology
Antioxidant and anti-inflammatory properties of naringenin could confer hepatoprotective effects. Chang cells in culture media were maintained at 37°C and treated with increased concentrations of glucose (5.5-50 mm) and/or naringenin (25-100 µm), respectively, for 24 h. The cells were harvested and carbonyl proteins, antioxidant enzymes and protein...
von Mentzer, Bengt Russo, Andrew F Zhang, Zhongming Kuburas, Adisa Killoran, Patrick M D'Aloisio, Vera Nizic, Laura Capel, Vicky Kendall, David A Coxon, Christopher R
...
Published in
The Journal of pharmacy and pharmacology
To investigate the formulation of the peptide-based antagonist (34 Pro,35 Phe)CGRP27-37 , of the human calcitonin gene-related peptide (CGRP) receptor as a potential nasally delivered migraine treatment. Peptide sequences were prepared using automated methods and purified by preparative HPLC. Their structure and stability were determined by LC-MS. ...
Cantelmo, Rebeca Araujo Dos Santos, Neife Aparecida G Dos Santos, Antonio Cardozo Joca, Sâmia Regiane Lourenço
Published in
The Journal of pharmacy and pharmacology
To investigate S-adenosyl-methyonine (SAM) effects on PC12 cells viability and neuritogenesis treated with MPP+ (1-methyl-4-phenylpyridinium). PC12 cell viability test (MTT assay) in DMEM medium with SAM and/or MPP+; PC12 cell neuritogenesis test in F-12K medium with nerve growth factor (NGF); DNMT activity in PC12 cells (DNMT Activity Assay Kit) w...
