Mendieta-Wejebe, Jessica Elena Silva-Trujillo, Arianna Bello, Martiniano Mendoza-Figueroa, Humberto L Galindo-Alvarez, Norma Lizeth Albores, Arnulfo Tamay-Cach, Feliciano Rosales-Hernández, Martha Cecilia Romero-Castro, Aurelio Correa-Basurto, José
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Published in
The Journal of pharmacy and pharmacology
N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), a derivative of valproic acid (VPA), has been proposed as a potential anticancer agent due to its improved antiproliferative effects in some cancer cell lines. Although there is evidence that VPA is metabolized by cytochrome P450 2C11 rat isoform, HO-AAVPA CYP-mediated metabolism has not yet been ...
Gupta, Priya Kumar, Amit Pal, Subhashis Kumar, Sachin Lahiri, Amit Kumaravelu, Jagavelu Chattopadhyay, Naibedya Dikshit, Madhu Barthwal, Manoj Kumar
Published in
The Journal of pharmacy and pharmacology
This study was undertaken to evaluate the effect of Xylocarpus moluccensis fruit fraction (F018) on the pathogenesis of collagen-induced arthritis in mice. Arthritis was induced by intradermal injection of collagen (2 mg/ml) with complete Freund's adjuvant in DBA/1J mice. F018 was administered orally at 1, 3 and 10 mg/kg for 20 days. Disease progre...
Su, Dan Wang, Wenbin Wu, Xinyue Li, Minyue Yan, Xuelong Hua, Zhonghong Liu, Jiahui Zhu, Zhiyu Hu, Kun Ren, Jie
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Published in
The Journal of pharmacy and pharmacology
Meriolins, a kind of chemical hybrid between meridianins and variolins, have lately been determined as kinase inhibitors and reportedly have antitumour activity. However, there is currently no in-depth study for the action mechanism. This study aimed to elucidate the potentially antitumour action mechanism of Meriolin1 on human neuroblastoma (SH-SY...
Yin, Rui Zhao, Shufa Qiu, Caixia
Published in
The Journal of pharmacy and pharmacology
As one of the vital nutrient factors in central nervous system (CNS), brain-derived neurotrophic factor (BDNF) can significantly attenuate neuron damage and promote neurogenesis. Nevertheless, little research has been conducted on regulating the effect of BDNF on the inflammatory response after traumatic brain injury (TBI). In this study, we used B...
Chan, Wai-Jo Jocelin McLachlan, Andrew J Hanrahan, Jane R Harnett, Joanna E
Published in
The Journal of pharmacy and pharmacology
Annona muricata, also known as graviola, soursop and guanabana, has been widely utilised for the treatment of a range of cancers. The mechanism of action and the efficacy of A. muricata and its constituents in the treatment of cancer have been comprehensively reviewed. The aim of this systematic review was to summarise the available literature that...
Tong, Hui Zhao, Kai Wang, Jiangjie Xu, Hui Xiao, Jianqi
Published in
The Journal of pharmacy and pharmacology
MicroRNAs are abundant in eukaryotic cells and play key roles in cancers. Circular RNAs (CircRNAs) served as the competing endogenous RNAs (ceRNAs) in mediating multiple cell processes. This study aims to define the role of CircRNA CircZNF609/miR-134-5p in glioma as well as the underlying regulating mechanism. Relative expression of miR-134-5p, Cir...
Guo, Yan Yu, Xiao-Meng Chen, Shuo Wen, Ji-Yue Chen, Zhi-Wu
Published in
The Journal of pharmacy and pharmacology
To study the effects of total flavones of Rhododendra simsii Planch flower (TFR) on hypoxia/reoxygenation (H/R) injury in rat hippocampal neurons and its underlying mechanism. Model of H/R was established in newborn rat primary cultured hippocampal neuron. Lactate dehydrogenase (LDH) and neuron-specific enolase (NSE) activity as well as malondialde...
Ruan, Hao Lv, Ziwei Liu, Shuaishuai Zhang, Liang Huang, Kai Gao, Shaoyan Gan, Wenhua Liu, Xiaowei Zhang, Shanshan Helian, Kaiyue
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Published in
The Journal of pharmacy and pharmacology
Anlotinib hydrochloride (AL3818) is a novel multitarget tyrosine kinase inhibitor which has the same targets as nintedanib, an effective drug has been approved for the treatment of idiopathic pulmonary fibrosis. Here, we examined whether anlotinib could also attenuate bleomycin-induced pulmonary fibrosis in mice and explored the antifibrosis mechan...
Kong, Weijun An, Huijing Zhang, Ji Sun, Lan Nan, Yao Song, Aili Zhou, Lidong
Published in
The Journal of pharmacy and pharmacology
This study aimed to develop an efficient and reliable method for estimating common adulterants in saffron by detecting their characteristic components to warrant its efficacy and regular use as a highly valuable medicinal herb. A selective and sensitive high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) method was dev...
Liu, Jia Zhang, Qing Li, Ruo-Lan Wei, Shu-Jun Huang, Chun-Yan Gao, Yong-Xiang Pu, Xu-Feng
Published in
The Journal of pharmacy and pharmacology
Cinnamomi ramulus (called Guizhi in Chinese) is a traditional medicine used to treat gastrointestinal dysfunction, cancer, arthritis, osteoporosis, spleen deficiency, Alzheimer's disease and obesity. This review aimed to provide a systematic summary on the geographical distribution, botany, traditional application, phytochemistry, pharmacology, pha...
