Potential Involvement of a Substantia Nigra Circuit in Opioid Reinforcement.
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Accounting for biases in the estimation of neuronal signal correlation.
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Signal correlation (r s) is commonly defined as the correlation between the tuning curves of two neurons and is widely used as a metric of tuning similarity. It is fundamental to how populations of neurons represent stimuli and has been central to many studies of neural coding. Yet the classic estimate, Pearson's correlation coefficient, [Formula: ...
A heteromodal word-meaning binding site in the visual word form area under top-down frontoparietal control.
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
The integral capacity of human language together with semantic memory drives the linkage of words and their meaning, which theoretically is subject to cognitive control. However, it remains unknown whether, across different language modalities and input/output formats, there is a shared system in the human brain for word-meaning binding and how thi...
Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb.
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Local interneurons of the olfactory bulb (OB) are densely innervated by long-range GABAergic neurons from the basal forebrain (BF), suggesting that this top-down inhibition regulates early processing in the olfactory system. However, how GABAergic inputs modulate the OB output neurons, the mitral/tufted cells, is unknown. Here, in male and female m...
Chronic Bilateral Cochlear Implant Stimulation Partially Restores Neural Binaural Sensitivity in Neonatally-Deaf Rabbits...
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Cochlear implant (CI) users with a pre-lingual onset of hearing loss show poor sensitivity to interaural time differences (ITD), an important cue for sound localization and speech reception in noise. Similarly, neural ITD sensitivity in the inferior colliculus (IC) of neonatally-deafened animals is degraded compared to animals deafened as adults. H...
VC neurons facilitate serotonin-induced egg laying The sex-specific VC neurons are mechanically activated motor neurons ...
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Successful execution of behavior requires coordinated activity and communication between multiple cell types. Studies using the relatively simple neural circuits of invertebrates have helped to uncover how conserved molecular and cellular signaling events shape animal behavior. To understand the mechanisms underlying neural circuit activity and beh...
Population coding of natural electrosensory stimuli by midbrain neurons.
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Natural stimuli display spatiotemporal characteristics that typically vary over orders of magnitude and their encoding by sensory neurons remains poorly understood. We investigated population coding of highly heterogeneous natural electro-communication stimuli in Apteronotus leptorhynchus of either sex. Neuronal activities were positively correlate...
Evaluating visual cues modulates their representation in mouse visual and cingulate cortex.
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Choosing an action in response to visual cues relies on cognitive processes, such as perception, evaluation, and prediction, which can modulate visual representations even at early processing stages. In the mouse, it is challenging to isolate cognitive modulations of sensory signals, because concurrent overt behavior patterns, such as locomotion, c...
Increased hippocampal excitability and altered learning dynamics mediate cognitive mapping deficits in human aging.
Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Learning the spatial layout of a novel environment is associated with dynamic activity changes in the hippocampus and in medial parietal areas. With advancing age, the ability to learn spatial environments deteriorates substantially but the underlying neural mechanisms are not well understood. Here, we report findings from a behavioral and a fMRI e...
Aberrant Maturation of the Uncinate Fasciculus Follows Exposure to Unpredictable Patterns of Maternal Signals.
...Published in The Journal of neuroscience : the official journal of the Society for Neuroscience
Across species, unpredictable patterns of maternal behavior are emerging as novel predictors of aberrant cognitive and emotional outcomes later in life. In animal models, exposure to unpredictable patterns of maternal behavior alters brain circuit maturation and cognitive and emotional outcomes. However, whether exposure to such signals in humans a...
