Park, Laibaik Zhou, Joan Koizumi, Kenzo Wang, Gang Anfray, Antoine Ahn, Sung Ji Seo, James Zhou, Ping Zhao, Lingzhi Paul, Steven
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The amyloid-β peptide (Aβ), a key pathogenic factor in Alzheimer's disease, attenuates the increase in cerebral blood flow (CBF) evoked by neural activity (functional hyperemia), a vital homeostatic response in which NMDA receptors (NMDAR) play a role through nitric oxide, and the CBF increase produced by endothelial factors. Tissue plasminogen act...
González, Andrés G Lazo, Oscar M Bronfman, Francisca C
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Brain-derived neurotrophic factor (BDNF) is a key regulator of the morphology and connectivity of central neurons. We have previously shown that BDNF/TrkB signaling regulates the activity and mobility of the GTPases Rab5 and Rab11, which in turn determine the postendocytic sorting of signaling TrkB receptors. Moreover, decreased Rab5 or Rab11 activ...
Hayashi, Masamichi J Ivry, Richard B
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The perception of duration in the subsecond range has been hypothesized to be mediated by the population response of duration-sensitive units, each tuned to a preferred duration. One line of support for this hypothesis comes from neuroimaging studies showing that cortical regions, such as in parietal cortex exhibit duration tuning. It remains uncle...
Taubert, Jessica Japee, Shruti Murphy, Aidan P Tardiff, Clarissa T Koele, Elissa A Kumar, Susheel Leopold, David A Ungerleider, Leslie G
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
When we move the features of our face, or turn our head, we communicate changes in our internal state to the people around us. How this information is encoded and utilized by an observer's brain is poorly understood. We investigated this issue using a functional MRI-adaptation paradigm in awake male macaques. Among face-selective patches of the sup...
Karunanithi, Shanker Lin, Yong Qi Odierna, G Lorenzo Menon, Hareesh Gonzalez, Juan Mena Neely, G Gregory Noakes, Peter G Lavidis, Nickolas A Moorhouse, Andrew J van Swinderen, Bruno
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Within mammalian brain circuits, activity-dependent synaptic adaptations such as synaptic scaling stabilise neuronal activity in the face of perturbations. Stability afforded through synaptic scaling involves uniform scaling of quantal amplitudes across all synaptic inputs formed on neurons, as well as on the postsynaptic side. It remains unclear w...
Kouwenhoven, Willemieke M Fortin, Guillaume Penttinen, Anna-Maija Florence, Clélia Delignat-Lavaud, Benoît Bourque, Marie-Josée Trimbuch, Thorsten Luppi, Milagros Pereira Salvail-Lacoste, Alix Legault, Pascale
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
A subset of adult ventral tegmental area (VTA) dopamine (DA) neurons expresses Vglut2, a vesicular glutamate transporter, and releases glutamate as a second neurotransmitter in the striatum, while only few adult substantia nigra (SN) DA neurons have this capacity. Recent work showed that cellular stress created by neurotoxins such as MPTP and 6-hyd...
Ravenscroft, Thomas A Janssens, Jasper Lee, Pei-Tseng Tepe, Burak Marcogliese, Paul C Makhzami, Samira Holmes, Todd C Aerts, Stein Bellen, Hugo J
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
In multipolar vertebrate neurons, action potentials (AP) initiate close to the soma, at the axonal initial segment (AIS). Invertebrate neurons are typically unipolar with dendrites integrating directly into the axon. Where APs are initiated in the axons of invertebrate neurons is unclear. Voltage-gated sodium (NaV) channels are a functional hallmar...
Raud, Liisa Huster, René J Ivry, Richard B Labruna, Ludovica Messel, Mari S Greenhouse, Ian
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
In our everyday behavior, we frequently cancel one movement while continuing others. Two competing models have been suggested for the cancellation of such specific actions: 1) the abrupt engagement of a unitary global inhibitory mechanism followed by reinitiation of the continuing actions, or 2) a balance between distinct global and selective inhib...
Hermiller, Molly S Chen, Yu Fen Parrish, Todd B Voss, Joel L
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The hippocampus supports episodic memory via interaction with a distributed brain network. Previous experiments using network-targeted noninvasive brain stimulation have identified episodic memory enhancements and modulation of activity within the hippocampal network. However, mechanistic insights were limited because these effects were measured lo...
Neyens, Drew Zhao, Huan Huston, Nathaneal J Wayman, Gary A Ritter, Robert C Appleyard, Suzanne M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Leptin signaling within the nucleus of the solitary tract (NTS) contributes to the control of food intake, and injections of leptin into the NTS reduce meal size and increase the efficacy of vagus-mediated satiation signals. Leptin receptors (LepRs) are expressed by vagal afferents as well as by a population of NTS neurons. However, the electrophys...
