Carraro, Rodrigo S Nogueira, Guilherme A Sidarta-Oliveira, Davi Gaspar, Rodrigo S Dragano, Nathalia R Morari, Joseane Bobbo, Vanessa C D Araujo, Eliana P Mendes, Natalia F Zanesco, Ariane M
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nescient helix-loop-helix 2 (NHLH2) is a hypothalamic transcription factor that controls the expression of prohormone convertase 1/3, therefore having an impact on the processing of proopiomelanocortin and thus on energy homeostasis. Studies have shown that knockout of Nhlh2 results in increased body mass, reduced physical activity and hypogonadism...
Carrero-Rojas, Génova Hernández, Rosendo G Blumer, Roland de la Cruz, Rosa R Pastor, Angel M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Multiply-innervated muscle fibers (MIFs) are peculiar to the extraocular muscles as they are non-twitch but produce a slow build up in tension upon repetitive stimulation. The motoneurons innervating MIFs establish en grappe terminals along the entire length of the fiber, instead of the typical en plaque terminals that singly-innervated muscle fibe...
Ramakrishna, Sarayu Jhaveri, Vishwaja Konings, Sabine C Nawalpuri, Bharti Chakraborty, Sumita Holst, Bjørn Schmid, Benjamin Gouras, Gunnar K Freude, Kristine K Muddashetty, Ravi S
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Apolipoprotein E (APOE), one of the primary lipoproteins in the brain has three isoforms in humans, APOE2, APOE3, and APOE4. APOE4 is the most well-established risk factor increasing the predisposition for Alzheimer's disease (AD). The presence of the APOE4 allele alone is shown to cause synaptic defects in neurons and recent studies have identifie...
Tatz, Joshua R Soh, Cheol Wessel, Jan R
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The ability to stop an already initiated action is paramount to adaptive behavior. Much scientific debate in the field of human action-stopping currently focuses on two interrelated questions. (1) Which cognitive and neural processes uniquely underpin the implementation of inhibitory control when actions are stopped after explicit stop signals, and...
Follis, Rose M Tep, Chhavy Genaro-Mattos, Thiago C Kim, Mi Lyang Ryu, Jae Cheon Morrison, Vivianne E Chan, Jonah R Porter, Ned Carter, Bruce D Yoon, Sung Ok
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
We report that the neurotrophin receptor p75 contributes to sensory neuron survival through the regulation of cholesterol metabolism in Schwann cells. Selective deletion of p75 in mouse Schwann cells of either sex resulted in a 30% loss of dorsal root ganglia (DRG) neurons and diminished thermal sensitivity. P75 regulates Schwann cell cholesterol b...
Berg, Elizabeth L Jami, Shekib A Petkova, Stela P Berz, Annuska Fenton, Timothy A Lerch, Jason P Segal, David J Gray, John A Ellegood, Jacob Wöhr, Markus
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder characterized by intellectual disabilities, motor and balance deficits, impaired communication, and a happy, excitable demeanor with frequent laughter. We sought to elucidate a preclinical outcome measure in male and female rats that addressed communication abnormalities of AS and...
Johnson, Caroline S Hong, Weizhe Micevych, Paul E
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Social behaviors, including reproductive behaviors, often display sexual dimorphism. Lordosis, the measure of female sexual receptivity, is one of the most apparent sexually dimorphic reproductive behaviors. Lordosis is regulated by estrogen and progesterone (P4) acting within a hypothalamic-limbic circuit, consisting of the arcuate, medial preopti...
Komuro, Yutaro Galas, Ludovic Morozov, Yury M Fahrion, Jennifer K Raoult, Emilie Lebon, Alexis Tilot, Amanda K Kikuchi, Shin Ohno, Nobuhiko Vaudry, David
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Galanin, one of the most inducible neuropeptides, is widely present in developing brains, and its expression is altered by pathologic events (e.g., epilepsy, ischemia, and axotomy). The roles of galanin in brain development under both normal and pathologic conditions have been hypothesized, but the question of how galanin is involved in fetal and e...
Speer, Sebastian P Smidts, Ale Boksem, Maarten A S
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cognitive control is crucially involved in making (dis)honest decisions. However, the precise nature of this role has been hotly debated. Is honesty an intuitive response, or is will power needed to override an intuitive inclination to cheat? A reconciliation of these conflicting views proposes that cognitive control enables dishonest participants ...
Lyu, Dian Pappas, Ioannis Menon, David K Stamatakis, Emmanuel A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Human brains interpret external stimuli based on internal representations. One untested hypothesis is that the default-mode network (DMN), widely considered responsible for internally oriented cognition, can decode external information. Here, we posit that the unique structural and functional fingerprint of the precuneus (PCu) supports a prominent ...
