Zhou, Lin Zhou, Liang Su, Li-da Cao, Sheng-Long Xie, Ya-Jun Wang, Na Shao, Chong-Yu Wang, Ya-Nan Zhou, Jia-Huan Cowell, John K
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that glutamatergic transmission is altered in LGI1 mutant mice and seizures can be reduced by restoring LGI1 function. Yet, the mechanism underlying ADLTE is unclear. Here, we propose th...
Li, Yan Missig, Galen Finger, Beate C Landino, Samantha M Alexander, Abigail J Mokler, Emery Robbins, James Manasian, Yunona Kim, Woori Kim, Kwang-Soo
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Inflammatory processes may be involved in the pathophysiology of neuropsychiatric illnesses including Autism Spectrum Disorder (ASD). Evidence from studies in rodents indicates that immune activation during early development can produce core features of ASD (social interaction deficits, dysregulation of communication, increases in stereotyped behav...
McMeekin, L J Li, Y Fox, S N Rowe, G C Crossman, D K Day, J J Li, Y Detloff, P J Cowell, R M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Multiple lines of evidence indicate that a reduction in the expression and function of the transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator-1α (PGC-1α) is associated with neurodegeneration in diseases such as Huntington Disease (HD). Polymorphisms in the PGC-1α gene modify HD progression, and PGC-1α expressio...
Lima-Filho, Ricardo A S Oliveira, Mauricio M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Henry, Fredrick E Wang, Xiao Serrano, David Perez, Amanda S Carruthers, Cynthia J L Stuenkel, Edward L Sutton, Michael A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
mTORC1-dependent translational control plays a key role in several enduring forms of synaptic plasticity such as long term potentiation (LTP) and mGluR-dependent long term depression. Recent evidence demonstrates an additional role in regulating synaptic homeostasis in response to inactivity, where dendritic mTORC1 serves to modulate presynaptic fu...
Pressler, R Todd Strowbridge, Ben W
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The olfactory bulb contains excitatory principal cells (mitral and tufted cells) that project to cortical targets as well as inhibitory interneurons. How the local circuitry in this region facilitates odor-specific output is not known, but previous work suggests that GABAergic granule cells plays an important role, especially during fine odor discr...
Chung, Hui-Kuan Tymula, Agnieszka Glimcher, Paul
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The population of people above 65 years old continues to grow, and there is mounting evidence that as humans age they are more likely to make errors. However, the specific effect of neuroanatomical aging on the efficiency of economic decision-making is poorly understood. We used whole-brain voxel-based morphometry analysis to determine where reduct...
Sadeh, Sadra Silver, R Angus Mrsic-Flogel, Thomas D Muir, Dylan Richard
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurons within cortical microcircuits are interconnected with recurrent excitatory synaptic connections that are thought to amplify signals (Douglas and Martin, 2007), form selective subnetworks (Ko et al., 2011), and aid feature discrimination. Strong inhibition (Haider et al., 2013) counterbalances excitation, enabling sensory features to be shar...
Orsini, Caitlin A Hernandez, Caesar M Singhal, Sarthak Kelly, Kyle B Frazier, Charles J Bizon, Jennifer L Setlow, Barry
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Decision making is a multifaceted process, consisting of several distinct phases that likely require different cognitive operations. Previous work showed that the basolateral amygdala (BLA) is a critical substrate for decision making involving risk of punishment; however, it is unclear how the BLA is recruited at different stages of the decision pr...
Pan, Ping-Yue Li, Xianting Wang, Jing Powell, James Wang, Qian Zhang, Yuanxi Chen, Zhaoyu Wicinski, Bridget Hof, Patrick Ryan, Timothy A
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Parkinson's disease (PD) is characterized pathologically by the selective loss of substantia nigra (SN) dopaminergic (DAergic) neurons. Recent evidence has suggested a role of LRRK2, linked to the most frequent familial PD, in regulating synaptic vesicle (SV) trafficking. However, the mechanism whereby LRRK2 mutants contribute to nigral vulnerabili...
