Persichetti, Andrew S Shao, Jiayu Gotts, Stephen J Martin, Alex
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neuroimaging studies of individuals with autism spectrum disorders (ASD) consistently find an aberrant pattern of "reduced" laterality in brain networks that support functions related to social communication and language. However, it is unclear how the underlying functional organization of these brain networks is altered in ASD individuals. We test...
Glavis-Bloom, Courtney Vanderlip, Casey R Reynolds, John H
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Aging is the greatest risk factor for the development of neurodegenerative diseases, yet we still do not understand how the aging process leads to pathological vulnerability. The research community has relied heavily on mouse models, but the considerable anatomical, physiological, and cognitive differences between mice and humans limit their transl...
Zhang 张吉祥, Jixiang Chen 陈少瑞, Shao-Rui Zhou 周孟华, Meng-Hua Jin 金道忠, Daozhong Chen 陈红, Hong Wang 王力, Li DePinho, Ronald A Pan 潘惠麟, Hui-Lin
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
α2δ-1 (encoded by the Cacna2d1 gene) is a newly discovered NMDA receptor-interacting protein and is the therapeutic target of gabapentinoids (e.g., gabapentin and pregabalin), frequently used for treating patients with neuropathic pain. Nerve injury causes sustained α2δ-1 upregulation in the dorsal root ganglion (DRG), which promotes NMDA receptor ...
Wangler, Lynde M Bray, Chelsea E Packer, Jonathan M Tapp, Zoe M Davis, Amara C O'Neil, Shane M Baetz, Kara Ouviña, Michelle Witzel, Mollie Godbout, Jonathan P
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Traumatic brain injury (TBI) is associated with chronic psychiatric complications and increased risk for development of neurodegenerative pathology. Aged individuals account for most TBI-related hospitalizations and deaths. Nonetheless, neurobiological mechanisms that underlie worsened functional outcomes after TBI in the elderly remain unclear. Th...
Tien, Nai-Wen Vitale, Carmela Badea, Tudor C Kerschensteiner, Daniel
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The mouse retina encodes diverse visual features in the spike trains of >40 retinal ganglion cell (RGC) types. Each RGC type innervates a specific subset of the >50 retinorecipient brain areas. Our catalog of RGC types and feature representations is nearing completion. Yet, we know little about where specific RGC types send their information. Furth...
Popovkina, Dina V Pasupathy, Anitha
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Feature selectivity of visual cortical responses measured during passive fixation provides only a partial view of selectivity because it does not account for the influence of cognitive factors. Here we focus on primate area V4 and ask how neuronal tuning is modulated by task engagement. We investigated whether responses to colored shapes during act...
Alefantis, Panos Lakshminarasimhan, Kaushik Avila, Eric Noel, Jean-Paul Pitkow, Xaq Angelaki, Dora E
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sensory evidence accumulation is considered a hallmark of decision-making in noisy environments. Integration of sensory inputs has been traditionally studied using passive stimuli, segregating perception from action. Lessons learned from this approach, however, may not generalize to ethological behaviors like navigation, where there is an active in...
Woolnough, Oscar Donos, Cristian Curtis, Aidan Rollo, Patrick S Roccaforte, Zachary J Dehaene, Stanislas Fischer-Baum, Simon Tandon, Nitin
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Reading words aloud is a fundamental aspect of literacy. The rapid rate at which multiple distributed neural substrates are engaged in this process can only be probed via techniques with high spatiotemporal resolution. We probed this with direct intracranial recordings covering most of the left hemisphere in 46 humans (26 male, 20 female) as they r...
Tadros, Timothy Bazhenov, Maxim
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Relational memory, the ability to make and remember associations between objects, is an essential component of mammalian reasoning. In relational memory tasks, it has been shown that periods of offline processing, such as sleep, are critical to making indirect associations. To understand biophysical mechanisms behind the role of sleep in improving ...
Zhao, Sijia Liu, Yajie Wei, Kunlin
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Autism spectrum disorder (ASD) is a developmental disorder that is characterized by difficulties with social interaction and interpersonal communication. It has been argued that abnormal attentional function to exogenous stimuli precedes and contributes to the core ASD symptoms. Notably, the locus ceruleus (LC) and its noradrenergic projections thr...
