Torretta, Silvia Rampino, Antonio Basso, Manuela Pergola, Giulio Di Carlo, Pasquale Shin, Joo H Kleinman, Joel E Hyde, Thomas M Weinberger, Daniel R Masellis, Rita
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Multiple schizophrenia (SCZ) risk loci may be involved in gene co-regulation mechanisms, and analysis of co-expressed gene networks may help to clarify SCZ molecular basis. We have previously identified a dopamine D2 receptor (DRD2) co-expression module enriched for SCZ risk genes and associated with cognitive and neuroimaging phenotypes of SCZ, as...
Abecassis, Zachary A Berceau, Brianna L Win, Phyo H Garcia, Daniela Xenias, Harry S Cui, Qiaoling Pamukcu, Arin Cherian, Suraj Hernández, Vivian M Chon, Uree
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in motor control. Aside from Foxp2+ neurons and ChAT+ neurons that have been established as unique neuron types, there is little consensus on the classification of GPe neurons. Properties of the remaining neuron types are poorly-defined. In this study, we le...
Kilteni, Konstantina Ehrsson, H Henrik
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Since the early 1970s, numerous behavioral studies have shown that self-generated touch feels less intense than the same touch applied externally. Computational motor control theories have suggested that cerebellar internal models predict the somatosensory consequences of our movements and that these predictions attenuate the perception of the actu...
Guo, Lin Lawrence Nestor, Adrian Nemrodov, Dan Frost, Adam Niemeier, Matthias
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The frontoparietal networks underlying grasping movements have been extensively studied, especially using fMRI. Accordingly, whereas much is known about their cortical locus much less is known about the temporal dynamics of visuomotor transformations. Here, we show that multivariate EEG analysis allows for detailed insights into the time course of ...
Hallinan, Grace I Vargas-Caballero, Mariana West, Jonathan Deinhardt, Katrin
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neurofibrillary tangles, formed of misfolded, hyperphosphorylated tau protein, are a pathological hallmark of several neurodegenerations, including Alzheimer's disease. Tau pathology spreads between neurons and propagates misfolding in a prion-like manner throughout connected neuronal circuits. Tauopathy is accompanied by significant neuronal death...
Yong, Yu Gamage, Kanchana Cheng, Irene Barford, Kelly Spano, Anthony Winckler, Bettina Deppmann, Christopher
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The regressive events associated with trophic deprivation are critical for sculpting a functional nervous system. After nerve growth factor withdrawal, sympathetic axons derived from male and female neonatal mice maintain their structural integrity for ∼18 h (latent phase) followed by a rapid and near unison disassembly of axons over the next 3 h (...
Jin, Ying-Hui Wu, Xin-Sheng Shi, Bo Zhang, Zhen Guo, Xiaoli Gan, Lin Chen, Zhongqing Wu, Ling-Gang
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Calcium influx triggers and facilitates endocytosis, which recycles vesicles and thus sustains synaptic transmission. Despite decades of studies, the underlying calcium sensor remained not well understood. Here, we examined two calcium binding proteins, protein kinase C (PKC) and calmodulin. Whether PKC is involved in endocytosis was unclear; wheth...
Nishino, Hironori Saito, Taro Wei, Ran Takano, Tetsuya Tsutsumi, Koji Taniguchi, Makoto Ando, Kanae Tomomura, Mineko Fukuda, Mitsunori Hisanaga, Shin-Ichi
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dendritic spines are postsynaptic protrusions at excitatory synapses that are critical for proper neuronal synaptic transmission. While lipid and protein membrane components are necessary for spine formation, it is largely unknown how they are recruited to developing spines. Endosomal trafficking is one mechanism that may influence this development...
Liberman, Leslie D Liberman, M Charles
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The mammalian cochlea is innervated by two cholinergic feedback systems called the medial olivocochlear (MOC) and lateral olivocochlear (LOC) pathways, which send control signals from the brainstem back to the outer hair cells and auditory-nerve fibers, respectively. Despite countless studies of the cochlear projections of these efferent fibers in ...
DeFazio, R Anthony Navarro, Marco A Adams, Caroline E Milescu, Lorin S Moenter, Suzanne M
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Synaptic and intrinsic properties interact to sculpt neuronal output. Kisspeptin neurons in the hypothalamic arcuate nucleus help convey homeostatic estradiol feedback to central systems controlling fertility. Estradiol increases membrane depolarization induced by GABAA receptor activation in these neurons. We hypothesized that the mechanisms under...
