Correction: The relationship between form and function throughout the history of excitation-contraction coupling.
Published in The Journal of general physiology
A role for P2X4 receptors in lysosome function.
Published in The Journal of general physiology
Looking in the rear-view mirror as we anticipate another 100 years.
Published in The Journal of general physiology
Up all night: BK channels' circadian dance with different calcium sources.
Published in The Journal of general physiology
JGP study explores diurnal changes in calcium sources governing BK activity in the SCN.
Influences: Growing up in Yale Physiology.
Published in The Journal of general physiology
The founding of Journal of General Physiology: Membrane permeation and ion selectivity.
Published in The Journal of general physiology
This essay begins with a description of the founding years of Journal of General Physiology (JGP) and a historical overview of the content of the journal. It then turns to key conceptual articles published in JGP that advanced the field of membrane permeation and ion selectivity. Much of this information comes from reading the online archives of JG...
A common mechanism for CFTR potentiators.
Published in The Journal of general physiology
Cystic fibrosis (CF) is a channelopathy caused by loss-of-function mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a phosphorylation-activated and adenosine triphosphate (ATP)-gated chloride channel. In the past few years, high-throughput drug screening has successfully realized the first US Food and ...
Asymmetry of inverted-topology repeats in the AE1 anion exchanger suggests an elevator-like mechanism.
Published in The Journal of general physiology
The membrane transporter anion exchanger 1 (AE1), or band 3, is a key component in the processes of carbon-dioxide transport in the blood and urinary acidification in the renal collecting duct. In both erythrocytes and the basolateral membrane of the collecting-duct α-intercalated cells, the role of AE1 is to catalyze a one-for-one exchange of chlo...
A new model for an old friend.
Published in The Journal of general physiology
JGP study suggests the anion exchanger AE1 operates via an elevator-like mechanism.
An atypical CaV1.1 mutation reveals a common mechanism for hypokalemic periodic paralysis.
Published in The Journal of general physiology
