Xiao, Yin Qureischi, Musga Dietz, Lena Vaeth, Martin Vallabhapurapu, Subrahmanya D Klein-Hessling, Stefan Klein, Matthias Liang, Chunguang König, Anika Serfling, Edgar
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Published in
The Journal of experimental medicine
Posttranslational modification with SUMO is known to regulate the activity of transcription factors, but how SUMOylation of individual proteins might influence immunity is largely unexplored. The NFAT transcription factors play an essential role in antigen receptor-mediated gene regulation. SUMOylation of NFATc1 represses IL-2 in vitro, but its rol...
Radermecker, Coraline Detrembleur, Nancy Guiot, Julien Cavalier, Etienne Henket, Monique d'Emal, Céline Vanwinge, Céline Cataldo, Didier Oury, Cécile Delvenne, Philippe
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Published in
The Journal of experimental medicine
Infection with SARS-CoV-2 is causing a deadly and pandemic disease called coronavirus disease-19 (COVID-19). While SARS-CoV-2-triggered hyperinflammatory tissue-damaging and immunothrombotic responses are thought to be major causes of respiratory failure and death, how they relate to lung immunopathological changes remains unclear. Neutrophil extra...
Jouan, Youenn Guillon, Antoine Gonzalez, Loïc Perez, Yonatan Boisseau, Chloé Ehrmann, Stephan Ferreira, Marion Daix, Thomas Jeannet, Robin François, Bruno
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Published in
The Journal of experimental medicine
COVID-19 includes lung infection ranging from mild pneumonia to life-threatening acute respiratory distress syndrome (ARDS). Dysregulated host immune response in the lung is a key feature in ARDS pathophysiology. However, cellular actors involved in COVID-19-driven ARDS are poorly understood. Here, in blood and airways of severe COVID-19 patients, ...
Veras, Flavio Protasio Pontelli, Marjorie Cornejo Silva, Camila Meirelles Toller-Kawahisa, Juliana E de Lima, Mikhael Nascimento, Daniele Carvalho Schneider, Ayda Henriques Caetité, Diego Tavares, Lucas Alves Paiva, Isadora M
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Published in
The Journal of experimental medicine
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved in COVID-19 patho...
Koay, Hui-Fern Fulford, Thomas S Godfrey, Dale I
Published in
The Journal of experimental medicine
In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventional T cells in severe COVID-19 patients. This may reflect a role in COVID-19 immunity or pathogenesis and potentially identifies new therapeutic targets for this disease. © 2020 Koay et al.
Palacio, Nicole Dangi, Tanushree Chung, Young Rock Wang, Yidan Loredo-Varela, Juan Luis Zhang, Zhongyao Penaloza-MacMaster, Pablo
Published in
The Journal of experimental medicine
Type I interferons (IFN-I) are a major antiviral defense and are critical for the activation of the adaptive immune system. However, early viral clearance by IFN-I could limit antigen availability, which could in turn impinge upon the priming of the adaptive immune system. In this study, we hypothesized that transient IFN-I blockade could increase ...
Laskowski, Tamara Rezvani, Katayoun
Published in
The Journal of experimental medicine
Immunotherapy has made a profound impact in the treatment of cancer in the last decade. Insights from the study of the intricate relationships between immune cells and cancer have led to the clinical development of strategies that redirect the power of the immune system to target and eliminate cancer. Today, immunotherapy represents a rapidly expan...
Vitiello, Gerardo A Miller, George
Published in
The Journal of experimental medicine
The role of IL-17 in cancer remains controversial. Emerging evidence suggests that during early oncogenesis IL-17 supports tumor growth, whereas in established tumors IL-17 production by γδ and Th17 cells potentiates antitumor immunity. Consequently, γδ and Th17 cells are attractive targets for immunotherapy in the IL-17 immune axis. To optimize IL...
Casanova, Jean-Laurent Holtzman, David M Kaech, Susan M Lanier, Lewis L Nathan, Carl F Rudensky, Alexander Y Tuveson, David Wolchok, Jedd D
Published in
The Journal of experimental medicine
The advance of science is dependent upon collaboration, which does not have a visa attached to it. Indeed, over 40% of all American-based Nobel Prize winners are immigrants, and data from the National Science Foundation show that 49% of postdocs and 29% of science and engineering faculty in the US are foreign-born. However, restrictive new immigrat...
Helfricht, Angela Thijssen, Peter E Rother, Magdalena B Shah, Rashmi G Du, Likun Takada, Sanami Rogier, Mélanie Moritz, Jacques IJspeert, Hanna Stoepker, Chantal
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Published in
The Journal of experimental medicine
The autosomal recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a genetically heterogeneous disorder. Despite the identification of the underlying gene defects, it is unclear how mutations in any of the four known ICF genes cause a primary immunodeficiency. Here we demonstrate that loss of ZBTB24 in B cells...