Stackowicz, Julien Gaudenzio, Nicolas Serhan, Nadine Conde, Eva Godon, Ophélie Marichal, Thomas Starkl, Philipp Balbino, Bianca Roers, Axel Bruhns, Pierre
...
Published in
The Journal of experimental medicine
Gain-of-function mutations in NLRP3 are responsible for a spectrum of autoinflammatory diseases collectively referred to as "cryopyrin-associated periodic syndromes" (CAPS). Treatment of CAPS patients with IL-1-targeted therapies is effective, confirming a central pathogenic role for IL-1β. However, the specific myeloid cell population(s) exhibitin...
Reuther, Peter Martin, Katrin Kreutzfeldt, Mario Ciancaglini, Matias Geier, Florian Calabrese, Diego Merkler, Doron Pinschewer, Daniel D
Published in
The Journal of experimental medicine
Several RNA viruses can establish life-long persistent infection in mammalian hosts, but the fate of individual virus-infected cells remains undefined. Here we used Cre recombinase-encoding lymphocytic choriomeningitis virus to establish persistent infection in fluorescent cell fate reporter mice. Virus-infected hepatocytes underwent spontaneous no...
Lopez, Jonathan Mommert, Marine Mouton, William Pizzorno, Andrés Brengel-Pesce, Karen Mezidi, Mehdi Villard, Marine Lina, Bruno Richard, Jean-Christophe Fassier, Jean-Baptiste
...
Published in
The Journal of experimental medicine
IFN-I and IFN-III immunity in the nasal mucosa is poorly characterized during SARS-CoV-2 infection. We analyze the nasal IFN-I/III signature, namely the expression of ISGF-3-dependent IFN-stimulated genes, in mildly symptomatic COVID-19 patients and show its correlation with serum IFN-α2 levels, which peak at symptom onset and return to baseline fr...
Li, Shuhang Wang, Linlin Xu, Zhihao Huang, Yuanyuan Xue, Rufeng Yue, Ting Xu, Linfeng Gong, Fanwu Bai, Shiyu Wu, Qielan
...
Published in
The Journal of experimental medicine
Activation of NLRP3 inflammasome is precisely controlled to avoid excessive activation. Although multiple molecules regulating NLRP3 inflammasome activation have been revealed, the checkpoints governing NLRP3 inflammasome activation remain elusive. Here, we show that activation of NLRP3 inflammasome is governed by GSTO1-promoted ASC deglutathionyla...
Michelow, Ian C Park, Sangshin Tsai, Shu-Whei Rayta, Bonnie Pasaje, Charisse Flerida A Nelson, Sara Early, Angela M Frosch, Anne P Ayodo, George Raj, Dipak K
...
Published in
The Journal of experimental medicine
We previously identified a Plasmodium falciparum (Pf) protein of unknown function encoded by a single-copy gene, PF3D7_1134300, as a target of antibodies in plasma of Tanzanian children in a whole-proteome differential screen. Here we characterize this protein as a blood-stage antigen that localizes to the surface membranes of both parasitized eryt...
Qadeer, Zulekha A Weiss, William A
Published in
The Journal of experimental medicine
In this issue of JEM, Guo et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202350) examine the importance of tumor-derived astrocytes in SHH-medulloblastoma recurrence. They show that tumor cells transdifferentiate to tumor-derived astrocytes via bone morphogenetic proteins and Sox9, which excitingly can be targeted by BMP inhibitors. © 2021...
Pruner, Kurt B Pepper, Marion
Published in
The Journal of experimental medicine
Respiratory viral infections present a major threat to global health and prosperity. Over the past century, several have developed into crippling pandemics, including the SARS-CoV-2 virus. Although the generation of neutralizing serum antibodies in response to natural immunity and vaccination are considered to be hallmarks of viral immune protectio...
Yang, Rui Weisshaar, Marc Mele, Federico Benhsaien, Ibtihal Dorgham, Karim Han, Jing Croft, Carys A Notarbartolo, Samuele Rosain, Jérémie Bastard, Paul
...
Published in
The Journal of experimental medicine
We have described a child suffering from Mendelian susceptibility to mycobacterial disease (MSMD) due to autosomal recessive, complete T-bet deficiency, which impairs IFN-γ production by innate and innate-like adaptive, but not mycobacterial-reactive purely adaptive, lymphocytes. Here, we explore the persistent upper airway inflammation (UAI) and b...
Ma, Shoubao Yan, Jiazhuo Barr, Tasha Zhang, Jianying Chen, Zhenhua Wang, Li-Shu Sun, Joseph C Chen, Jianjun Caligiuri, Michael A Yu, Jianhua
...
Published in
The Journal of experimental medicine
N 6-methyladenosine (m6A) is the most prevalent posttranscriptional modification on RNA. NK cells are the predominant innate lymphoid cells that mediate antiviral and antitumor immunity. However, whether and how m6A modifications affect NK cell immunity remain unknown. Here, we discover that YTHDF2, a well-known m6A reader, is upregulated in NK cel...
McCann, Chase D van Dorp, Christiaan H Danesh, Ali Ward, Adam R Dilling, Thomas R Mota, Talia M Zale, Elizabeth Stevenson, Eva M Patel, Shabnum Brumme, Chanson J
...
Published in
The Journal of experimental medicine
HIV-specific CD8+ T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4+ T cells from HIV+ donors uniquely allows for the in vivo evaluation of autologous T cell responses while avoiding graft-versus-host...
