Yang, Jing Schleicher, Tyler R Dong, Yuemei Park, Hyun Bong Lan, Jiangfeng Cresswell, Peter Crawford, Jason Dimopoulos, George Fikrig, Erol
Published in
The Journal of experimental medicine
Plasmodium infection in Anopheles is influenced by mosquito-derived factors. We previously showed that a protein in saliva from infected Anopheles, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT), inhibits the ability of sporozoites to traverse cells and readily establish infection of the vertebrate host. To determine whethe...
Haeger, Anna Alexander, Stephanie Vullings, Manon Kaiser, Fabian M P Veelken, Cornelia Flucke, Uta Koehl, Gudrun E Hirschberg, Markus Flentje, Michael Hoffman, Robert M
...
Published in
The Journal of experimental medicine
Cancer fatalities result from metastatic dissemination and therapy resistance, both processes that depend on signals from the tumor microenvironment. To identify how invasion and resistance programs cooperate, we used intravital microscopy of orthotopic sarcoma and melanoma xenografts. We demonstrate that these tumors invade collectively and that, ...
Di Biase, Stefano Ma, Xiaoya Wang, Xi Yu, Jiaji Wang, Yu-Chen Smith, Drake J Zhou, Yang Li, Zhe Kim, Yu Jeong Clarke, Nicole
...
Published in
The Journal of experimental medicine
T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, which encodes a surface transporter controlling the up...
Tokunaga, Akihiro Sugiyama, Daisuke Maeda, Yuka Warner, Allison Betof Panageas, Katherine S Ito, Sachiko Togashi, Yosuke Sakai, Chika Wolchok, Jedd D Nishikawa, Hiroyoshi
...
Published in
The Journal of experimental medicine
Patients treated with immune checkpoint blockade (ICB) sometimes experience immune-related adverse events (irAEs), requiring immuno-suppressive drugs such as corticosteroids despite the possibility that immunosuppression may impair the antitumor effects of ICB. Here, we address the dilemma of using corticosteroids for the treatment of irAEs induced...
Rodriguez, Rémy Fournier, Benjamin Cordeiro, Debora Jorge Winter, Sarah Izawa, Kazushi Martin, Emmanuel Boutboul, David Lenoir, Christelle Fraitag, Sylvie Kracker, Sven
...
Published in
The Journal of experimental medicine
Infection of T cells by Epstein-Barr virus (EBV) causes chronic active EBV infection (CAEBV) characterized by T cell lymphoproliferative disorders (T-LPD) of unclear etiology. Here, we identified two homozygous biallelic loss-of-function mutations in PIK3CD and TNFRSF9 in a patient who developed a fatal CAEBV. The mutation in TNFRSF9 gene coding CD...
Knipfer, Lisa Schulz-Kuhnt, Anja Kindermann, Markus Greif, Vicky Symowski, Cornelia Voehringer, David Neurath, Markus F Atreya, Imke Wirtz, Stefan
Published in
The Journal of experimental medicine
Group 2 innate lymphoid cells (ILC2s) possess indispensable roles during type 2-mediated inflammatory diseases. Although their physiological and detrimental immune functions seem to depend on the anatomical compartment they reside, their tissue tropism and the molecular and immunological processes regulating the self-renewal of the local pool of IL...
Volk, Joana K Nyström, Elisabeth E L van der Post, Sjoerd Abad, Beatriz M Schroeder, Bjoern O Johansson, Åsa Svensson, Frida Jäverfelt, Sofia Johansson, Malin E V Hansson, Gunnar C
...
Published in
The Journal of experimental medicine
The inner mucus layer (IML) is a critical barrier that protects the colonic epithelium from luminal threats and inflammatory bowel disease. Innate immune signaling is thought to regulate IML formation via goblet cell Nlrp6 inflammasome activity that controls secretion of the mucus structural component Muc2. We report that isolated colonic goblet ce...
Ma, Qiaoli Decker, Yann Müller, Andreas Ineichen, Benjamin V Proulx, Steven T
Published in
The Journal of experimental medicine
The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lymphatic vessels. Here, we use near-infrared and magnetic resonance imaging to demonstrate the flow of CS...
Li, Sheng Wu, Yuqing Yang, Dongxue Wu, Chunyan Ma, Chunmei Liu, Xue Moynagh, Paul N Wang, Bingwei Hu, Gang Yang, Shuo
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Published in
The Journal of experimental medicine
The NLRP3 inflammasome is critical for EAE pathogenesis; however, the role of gasdermin D (GSDMD), a newly identified pyroptosis executioner downstream of NLRP3 inflammasome, in EAE has not been well defined. Here, we observed that the levels of GSDMD protein were greatly enhanced in the CNS of EAE mice, especially near the areas surrounding blood ...
Saraiva, Margarida Vieira, Paulo O'Garra, Anne
Published in
The Journal of experimental medicine
The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from over-exuberant responses to pathogens and microbiota, while playing important roles in other settings as sterile wound healing, autoimmunity, cancer, and homeostasis. Here we discuss our current understanding of the regulation of IL-10 production and of the mo...
