Li, Ziru Rosen, Clifford J
Published in
The Journal of clinical endocrinology and metabolism
Bone marrow adipose tissue (BMAT) makes up a significant portion of the marrow space, ranging from 50% to 70%, in healthy adults. It expands with aging, obesity, anorexia nervosa, and irradiation, which are conditions associated with skeletal complications or hematopoietic disorders. Therefore, BMAT has been viewed as a negative component of the bo...
Thøgersen, Maja Nielsen, Karoline Kragelund Wibaek, Rasmus Damm, Peter Jensen, Rikke Beck Nielsen, Helene Maindal, Helle Terkildsen Andersen, Gregers Stig
Published in
The Journal of clinical endocrinology and metabolism
Children exposed to gestational diabetes mellitus (GDM) in utero are at high risk of developing overweight and obesity, but their postnatal growth trajectories and risk profiles remain unclear. We aimed to identify distinct body mass index (BMI) trajectories from birth to 10 years of age in children exposed to GDM and to explore their associations ...
Kahaly, George J Dolman, Peter J Wolf, Jan Giers, Bert C Elflein, Heike M Jain, Amy P Srinivasan, Ashok Hadjiiski, Lubomir Jordan, David Bradley, Elizabeth A
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Published in
The Journal of clinical endocrinology and metabolism
Inhibition of the neonatal fragment crystallizable receptor (FcRn) reduces pathogenic thyrotropin receptor antibodies (TSH-R-Ab) that drive pathology in thyroid eye disease (TED). We report the first clinical studies of an FcRn inhibitor, batoclimab, in TED. Proof-of-concept (POC) and randomized, double-blind placebo-controlled trials. Multicenter....
Wu, Chih-Hsing Li, Chia-Chun
Published in
The Journal of clinical endocrinology and metabolism
Dichtel, Laura E Corey, Kathleen E Haines, Melanie S Chicote, Mark L Lee, Hang Kimball, Allison Colling, Caitlin Simon, Tracey G Long, Michelle T Husseini, Jad
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Published in
The Journal of clinical endocrinology and metabolism
Overweight and obesity are associated with relative growth hormone (GH) deficiency, which has been implicated in the development of nonalcoholic fatty liver disease (NAFLD). NAFLD is a progressive disease without effective treatments. We hypothesized that GH administration would reduce hepatic steatosis in individuals with overweight/obesity and NA...
Arshad, Muhammad Fahad Elamin, Aisha Bennet, William Choudhari, Yashashri Kishor Balasubramanian, Saba P
Published in
The Journal of clinical endocrinology and metabolism
Precise estimates of the incidence of hyper- and hypocalcemia in pregnancy are unknown. Abnormal calcium levels have been associated with unfavorable pregnancy-related outcomes. Determine frequency of hypercalcemia and hypocalcemia in pregnancy when tested and their associations with maternal and fetal outcomes. Exploratory retrospective cohort stu...
Gadelha, Mônica Marques, Nelma Verônica Fialho, Christhiane Scaf, Cristiane Lamback, Elisa Antunes, Ximene Santos, Erica Magalhães, Jaqueline Wildemberg, Luiz Eduardo
Published in
The Journal of clinical endocrinology and metabolism
Acromegaly is a rare, chronic, debilitating disorder caused by prolonged hypersecretion of growth hormone (GH) and overproduction of insulin-like growth factor I (IGF-I). Medical therapies, including the somatostatin receptor ligand (SRL) pasireotide, are frequently used to restore biochemical control. As patients often receive therapy over prolong...
Simmons, Kimber M Sims, Emily K
Published in
The Journal of clinical endocrinology and metabolism
A diagnosis of type 1 diabetes (T1D) and the subsequent requirement for exogenous insulin treatment is associated with considerable acute and chronic morbidity and a substantial effect on patient quality of life. Importantly, a large body of work suggests that early identification of presymptomatic T1D can accurately predict clinical disease, and w...
Xue, Pei Nôga, Diana A Benedict, Christian
Published in
The Journal of clinical endocrinology and metabolism
Fleseriu, Maria Molitch, Mark Dreval, Alexander Pokramovich, Yulia Bondar, Irina Poteshkin, Yury Macut, Djuro Obermayer-Pietsch, Barbara Gilgun-Sherki, Yossi Haviv, Asi
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Published in
The Journal of clinical endocrinology and metabolism
The MPOWERED core trial (NCT02685709) and open-label extension (OLE) phase investigated long-term efficacy and safety of oral octreotide capsules (OOC) in patients with acromegaly. Core trial primary endpoint data demonstrated noninferiority to injectable somatostatin receptor ligands (iSRLs). Core trial completers were invited to participate in th...
