Light, Taylor P Gomez-Soler, Maricel Wang, Zichen Karl, Kelly Zapata-Mercado, Elmer Gehring, Marina P Lechtenberg, Bernhard C Pogorelov, Taras V Hristova, Kalina Pasquale, Elena B
...
Published in
The Journal of biological chemistry
The Eph receptor tyrosine kinases and their ephrin ligands regulate many physiological and pathological processes. EphA4 plays important roles in nervous system development and adult homeostasis, while aberrant EphA4 signaling has been implicated in neurodegeneration. EphA4 may also affect cancer malignancy, but the regulation and effects of EphA4 ...
Harwood, Seandean Lykke Nielsen, Nadia Sukusu Diep, Khang Jensen, Kathrine Tejlgård Nielsen, Peter Kresten Yamamoto, Kazuhiro Enghild, Jan J
Published in
The Journal of biological chemistry
Human α2-macroglobulin (A2M) is an abundant protease inhibitor in plasma which regulates many proteolytic processes and is involved in innate immunity. A2M's unique protease-trapping mechanism of inhibition is initiated when a protease cleaves within the exposed and highly susceptible "bait region". As the wildtype bait region is permissive to clea...
Corgiat, Edwin B List, Sara M Rounds, J Christopher Corbett, Anita H Moberg, Kenneth H
Published in
The Journal of biological chemistry
The human ZC3H14 gene, which encodes a ubiquitously expressed polyadenosine zinc finger RNA binding protein, is mutated in an inherited form of autosomal recessive, non-syndromic intellectual disability. To gain insight into neurological functions of ZC3H14, we previously developed a Drosophila melanogaster model of ZC3H14 loss by deleting the fly ...
Pascarelli, Stefano Merzhakupova, Dalmira Uechi, Gen-Ichiro Laurino, Paola
Published in
The Journal of biological chemistry
The Epidermal Growth Factor Receptor (EGFR) is a membrane-anchored tyrosine kinase that is able to selectively respond to multiple extracellular stimuli. Previous studies have indicated that the modularity of this system may be caused by ligand-induced differences in the stability of the receptor dimer. However, this hypothesis has not been explore...
Ehrencrona, Erik van der Post, Sjoerd Gallego, Pablo Recktenwald, Christian V Rodriguez-Pineiro, Ana M Garcia-Bonete, Maria-Jose Trillo-Muyo, Sergio Bäckström, Malin Hansson, Gunnar C Johansson, Malin E V
...
Published in
The Journal of biological chemistry
Mucus forms an important protective barrier that minimizes bacterial contact with the colonic epithelium. Intestinal mucus is organized in a complex network with several specific proteins, including the mucin MUC2 and the as abundant IgG Fc-binding protein, FCGBP. FCGBP is expressed in all intestinal goblet cells and is secreted into the mucus. It ...
Pan, Ping-Yue Zhu, Justin Rizvi, Asma Zhu, Xinyu Tanaka, Hikari Dreyfus, Cheryl F
Published in
The Journal of biological chemistry
Macroautophagy dysregulation is implicated in multiple neurological disorders, such as Parkinson's disease. While autophagy pathways are heavily researched in heterologous cells and neurons, regulation of autophagy in the astrocyte, the most abundant cell type in the mammalian brain, is less well understood. Missense mutations in the Synj1 gene enc...
Ghosh, Gairika Sharma, Pankaj V Kumar, Amit Jain, Sriyans Sen, Ranjan
Published in
The Journal of biological chemistry
The transcription terminator Rho regulates many physiological processes in bacteria, such as antibiotic sensitivity, DNA repair, RNA-remodeling, etc, and hence, is a potential antimicrobial target, which is unexplored. The bacteriophage P4 capsid protein, Psu, moonlights as a natural Rho antagonist. Here, we report the design of novel peptides base...
Gordon, Calvin J Tchesnokov, Egor P Schinazi, Raymond F Götte, Matthias
Published in
The Journal of biological chemistry
The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus 2 is an important target in current drug development efforts for the treatment of coronavirus disease 2019. Molnupiravir is a broad-spectrum antiviral that is an orally bioavailable prodrug of the nucleoside analogue β-D-N4-hydroxycytidine (NHC). Molnupiravir or N...
Kitai, Katsuki Kawaguchi, Kosuke Tomohiro, Takenori Morita, Masashi So, Takanori Imanaka, Tsuneo
Published in
The Journal of biological chemistry
Vitamin B12 (cobalamin) is an essential micronutrient for human health, and mutation and dysregulation of cobalamin metabolism are associated with serious diseases, such as methylmalonic aciduria and homocystinuria. Mutations in ABCD4 or LMBRD1, which encode the ATP-binding cassette (ABC) transporter ABCD4 and lysosomal membrane protein LMBD1, resp...
Hemmann, Jethro L Brühwiler, Manuel R Bortfeld-Miller, Miriam Vorholt, Julia A
Published in
The Journal of biological chemistry
Methylofuran (MYFR) is a formyl-carrying coenzyme essential for the oxidation of formaldehyde in most methylotrophic bacteria. In Methylorubrum extorquens, MYFR contains a large and branched polyglutamate side chain of up to 24 glutamates. These glutamates play an essential role in interfacing the coenzyme with the formyltransferase/hydrolase compl...
