Miller, Michelle S Douglass, Jacqueline Hwang, Michael S Skora, Andrew D Murphy, Michael Papadopoulos, Nickolas Kinzler, Kenneth W Vogelstein, Bert Zhou, Shibin Gabelli, Sandra B
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Published in
The Journal of biological chemistry
Mutations in CTNNB1, the gene encoding β-catenin, are common in colon and liver cancers, the most frequent mutation affecting Ser-45 in β-catenin. Peptides derived from WT β-catenin have previously been shown to be presented on the cell surface as part of major histocompatibility complex (MHC) class I, suggesting an opportunity for targeting this c...
Zhu, Beika Luo, Rong Jin, Peng Li, Tao Oak, Hayeon C Giera, Stefanie Monk, Kelly R Lak, Parnian Shoichet, Brian K Piao, Xianhua
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Published in
The Journal of biological chemistry
Adhesion G protein-coupled receptors (aGPCRs) represent a distinct family of GPCRs that regulate several developmental and physiological processes. Most aGPCRs undergo GPCR autoproteolysis-inducing domain-mediated protein cleavage, which produces a cryptic tethered agonist (termed Stachel (stinger)), and cleavage-dependent and -independent aGPCR si...
Tripathi, Ashutosh Martinez, Elliott Obaidullah, Ahmad J Lete, Marta G Lönnfors, Max Khan, Danish Soni, Krishnakant G Mousley, Carl J Kellogg, Glen E Bankaitis, Vytas A
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Published in
The Journal of biological chemistry
Phosphatidylinositol-transfer proteins (PITPs) are key regulators of lipid signaling in eukaryotic cells. These proteins both potentiate the activities of phosphatidylinositol (PtdIns) 4-OH kinases and help channel production of specific pools of phosphatidylinositol 4-phosphate (PtdIns(4)P) dedicated to specific biological outcomes. In this manner...
Morris, Daniel L Kastner, David W Johnson, Sabrina Strub, Marie-Paule He, Yi Bleck, Christopher K E Lee, Duck-Yeon Tjandra, Nico
Published in
The Journal of biological chemistry
The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2-associated X apoptosis regulator (BAX) plays a pivotal role in the initiation of mitochondria-mediated apoptosis as one of the factors causing mitochondrial outer-membrane permeabilization (MOMP). Of current inter...
Grifoll-Romero, Laia Sainz-Polo, María Angela Albesa-Jové, David Guerin, Marcelo E Biarnés, Xevi Planas, Antoni
Published in
The Journal of biological chemistry
Bacillus subtilis PdaC (BsPdaC) is a membrane-bound, multidomain peptidoglycan N-deacetylase acting on N-acetylmuramic acid (MurNAc) residues and conferring lysozyme resistance to modified cell wall peptidoglycans. BsPdaC contains a C-terminal family 4 carbohydrate esterase (CE4) catalytic domain, but unlike other MurNAc deacetylases, BsPdaC also h...
Nguyen, Lien D Petri, Edward T Huynh, Larry K Ehrlich, Barbara E
Published in
The Journal of biological chemistry
Inositol 1,4,5-trisphosphate receptors (InsP3Rs) are endoplasmic reticulum-localized channels that mediate Ca2+ release from the endoplasmic reticulum into the cytoplasm. We previously reported that an EF-hand Ca2+-binding protein, neuronal calcium sensor 1 (NCS1), binds to the InsP3R and thereby increases channel open probability, an event associa...
Saini, Adesh Kumar Maithal, Kapil Chand, Prem Chowdhury, Shantanu Vohra, Reena Goyal, Anita Dubey, Gyanendra P Chopra, Puneet Chandra, Ramesh Tyagi, Anil K
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Published in
The Journal of biological chemistry
Gao, Liwei Xu, Yanning Song, Xin Li, Shiying Xia, Chengqiang Xu, Jiadi Qin, Yuqi Liu, Guodong Qu, Yinbo
Published in
The Journal of biological chemistry
Enzymes that degrade lignocellulose to simple sugars are of great interest in research and for biotechnology because of their role in converting plant biomass to fuels and chemicals. The synthesis of cellulolytic enzymes in filamentous fungi is tightly regulated at the transcriptional level, with the transcriptional activator ClrB/CLR-2 playing a c...
Trautz, Birthe Wiedemann, Hanna Lüchtenborg, Christian Pierini, Virginia Kranich, Jan Glass, Bärbel Kräusslich, Hans-Georg Brocker, Thomas Pizzato, Massimo Ruggieri, Alessia
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Published in
The Journal of biological chemistry
Kim, Hyung-Gu Hwang, So-Young Aaronson, Stuart A Mandinova, Anna Lee, Sam W
Published in
The Journal of biological chemistry
