Wang, Heng Xu, Min Engelhart, Curtis A Zhang, Xi Yan, Baohua Pan, Miaomiao Xu, Yuanyuan Fan, Shilong Liu, Renhe Xu, Lan
...
Published in
The Journal of biological chemistry
Mycobacteria tuberculosis (Mtb) remains the deadliest pathogenic bacteria worldwide. The search for new antibiotics to treat drug-sensitive as well as drug-resistant tuberculosis has become a priority. The essential enzyme phenylalanyl-tRNA synthetase (PheRS) is an antibacterial drug target because of the large differences between bacterial and hum...
Malladi, Sameer Kumar Singh, Randhir Pandey, Suman Gayathri, Savitha Kanjo, Kawkab Ahmed, Shahbaz Khan, Mohammad Suhail Kalita, Parismita Girish, Nidhi Upadhyaya, Aditya
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Published in
The Journal of biological chemistry
Virtually all SARS-CoV-2 vaccines currently in clinical testing are stored in a refrigerated or frozen state prior to use. This is a major impediment to deployment in resource-poor settings. Furthermore, several of them use viral vectors or mRNA. In contrast to protein subunit vaccines, there is limited manufacturing expertise for these nucleic-aci...
Boson, Bertrand Legros, Vincent Zhou, Bingjie Siret, Eglantine Mathieu, Cyrille Cosset, François-Loïc Lavillette, Dimitri Denolly, Solène
Published in
The Journal of biological chemistry
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a β-coronavirus, is the causative agent of the COVID-19 pandemic. Like for other coronaviruses, its particles are composed of four structural proteins: Spike (S), Envelope (E), Membrane (M) and Nucleoprotein (N) proteins. The involvement of each of these proteins and their interactio...
Frandsen, Kristian E H Haon, Mireille Grisel, Sacha Henrissat, Bernard Lo Leggio, Leila Berrin, Jean-Guy
Published in
The Journal of biological chemistry
Understanding enzymatic breakdown of plant biomass is crucial to develop nature-inspired biotechnological processes. Lytic polysaccharide monooxygenases (LPMOs) are microbial enzymes secreted by fungal saprotrophs involved in carbon recycling. LPMOs modify biomass by oxidatively cleaving polysaccharides thereby enhancing the efficiency of glycoside...
Harris, Lee D Le Pen, Janic Scholz, Nico Mieszczanek, Juliusz Vaughan, Natalie Davis, Simon Berridge, Georgina Kessler, Benedikt Bienz, Mariann Licchesi, Julien D F
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Published in
The Journal of biological chemistry
Ubiquitin is a versatile post-translational modification which is covalently attached to protein targets either as a single moiety or as a ubiquitin chain. In contrast to K48 and K63-linked chains which have been extensively studied, the regulation and function of most atypical ubiquitin chains is only starting to emerge. The deubiquitinase TRABID/...
LaBreck, Christopher J Trebino, Catherine E Ferreira, Colby N Morrison, Josiah J DiBiasio, Eric C Conti, Joseph Camberg, Jodi L
Published in
The Journal of biological chemistry
MinD is a cell division ATPase in Escherichia coli that oscillates from pole to pole and regulates the spatial position of the cell division machinery. Together with MinC and MinE, the Min system restricts assembly of the FtsZ-ring to midcell, oscillating between the opposite ends of the cell and preventing FtsZ-ring misassembly at the poles. Here,...
Johnston, Caitlin L Marzano, Nicholas R Paudel, Bishnu P Wright, George Benesch, Justin L P van Oijen, Antoine M Ecroyd, Heath
Published in
The Journal of biological chemistry
Small heat shock proteins (sHsps) are a family of ubiquitous intracellular molecular chaperones that are up-regulated under stress conditions and play a vital role in protein homeostasis (proteostasis). It is commonly accepted that these chaperones work by trapping misfolded proteins to prevent their aggregation; however, fundamental questions rega...
Kumar, Ravi Poria, Dipak Kumar Ray, Partho Sarothi
Published in
The Journal of biological chemistry
Post-transcriptional regulation of gene expression plays a critical role in controlling the inflammatory response. An uncontrolled inflammatory response results in chronic inflammation, often leading to tumorigenesis. Programmed cell death 4 (PDCD4) is a pro-inflammatory tumor-suppressor gene which helps to prevent the transition from chronic infla...
Ceraudo, Emilie Horioka, Mizuho Mattheisen, Jordan M Hitchman, Tyler D Moore, Amanda R Kazmi, Manija A Chi, Ping Chen, Yu Sakmar, Thomas P Huber, Thomas
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Published in
The Journal of biological chemistry
Uveal melanoma is the most common eye cancer in adults and is clinically and genetically distinct from skin cutaneous melanoma. In a subset of cases, the oncogenic driver is an activating mutation in CYSLTR2, the gene encoding the G protein-coupled receptor (GPCR) cysteinyl-leukotriene receptor 2. The mutant CYSLTR2 encodes for CysLTR2-L129Q recept...
Zheng, Lifeng Xie, Chengbin Zheng, Ju Dong, Qiangrui Si, Tengxiao Zhang, Jing Hou, Sheng-Tao
Published in
The Journal of biological chemistry
Promoting brain recovery after stroke is challenging as a plethora of inhibitory molecules are produced in the brain preventing it from full healing. Moreover, the full scope of inhibitory molecules produced is not well understood. Here, using a high-sensitivity UPLC-MS-based shotgun lipidomics strategy, we semi-quantitively measured the differenti...
