Faraj, Santiago E Valsecchi, Wanda M Ferreira-Gomes, Mariela Centeno, Mercedes Saint Martin, Elina Malѐn Fedosova, Natalya U Rossi, Juan Pablo Fc Montes, MÓnica R Rossi, Rolando C
Published in
The Journal of biological chemistry
The Na+/K+-ATPase is an integral plasma membrane glycoprotein of all animal cells that couples the exchange of intracellular Na+ for extracellular K+ to the hydrolysis of ATP. The asymmetric distribution of Na+ and K+ is essential for cellular life and constitutes the physical basis of a series of fundamental biological phenomena. The pumping mecha...
Wang, Wenjuan Zhang, Zhaohan Zhao, Minghui Wang, Yu Ge, Yuze Shan, Lin
Published in
The Journal of biological chemistry
CXXC5, a member of the CXXC family of zinc-finger proteins, is associated with numerous pathological processes. However, the pathophysiological function of CXXC5 has not been clearly established. Herein, we found that CXXC5 interacts with the CRL4B and NuRD complexes. Screening of transcriptional targets downstream of the CXXC5-CRL4B-NuRD complex b...
Yin, Terry C Mittal, Ayushi Buscaglia, Paul Li, Wenxian Sebag, Julien A
Published in
The Journal of biological chemistry
The regulation of energy homeostasis is a complex system involving multiple hormones, neuropeptides, and receptors. Prokineticins (PK1 and PK2) are agonists to two GPCRs, Prokineticin receptor 1 and 2 (PKR1 and PKR2), which decrease food intake when injected in rodents. The relative contribution of PKR1 and PKR2 to the anorexigenic effect of PK2 an...
Rangarajan, Erumbi S Smith, Emmanuel W Izard, Tina
Published in
The Journal of biological chemistry
The regulation of cell-cell junctions during epidermal morphogenesis ensures tissue integrity, a process regulated by α-catenin. This cytoskeletal protein connects the cadherin complex to filamentous actin at cell-cell junctions. The cadherin-catenin complex plays key roles in cell physiology, organism development, and disease. While mutagenesis of...
Higerd-Rusli, Grant P Tyagi, Sidharth Liu, Shujun Dib-Hajj, Fadia B Waxman, Stephen G Dib-Hajj, Sulayman D
Published in
The Journal of biological chemistry
Neuronal function relies on the maintenance of appropriate levels of various ion channels at the cell membrane, which is accomplished by balancing secretory, degradative, and recycling pathways. Neuronal function further depends on membrane specialization through polarized distribution of specific proteins to distinct neuronal compartments such as ...
Young-Baird, Sara K
Published in
The Journal of biological chemistry
Loss of function of the RNA-binding protein FMRP causes fragile X syndrome, the most common inherited form of intellectual disability and autism spectrum disorders. FMRP is suggested to modulate synaptic plasticity by regulating the synthesis of proteins involved in neuronal and synaptic function; however, the mechanism underlying FMRP mRNA targeti...
Yamagami, Ryota Hori, Hiroyuki
Published in
The Journal of biological chemistry
Transfer RNAs undergo diverse posttranscriptional modifications to regulate a myriad of cellular events including translation, stress response, and viral replication. These posttranscriptional modifications are synthesized by site-specific modification enzymes. Recent RNA-seq techniques have revealed multiple features of tRNA such as tRNA abundance...
Servius, Hardler W Pidugu, Lakshmi S Sherman, Matthew E Drohat, Alexander C
Published in
The Journal of biological chemistry
Oxidation of DNA bases generates mutagenic and cytotoxic lesions that are implicated in cancer and other diseases. Oxidative base lesions, including 7,8-dihydro-8-oxoguanine, are typically removed through base excision repair. In addition, oxidized deoxynucleotides such as 8-oxo-dGTP are depleted by sanitizing enzymes to preclude DNA incorporation....
Raicu, Ana-Maria Fay, Justin C Rohner, Nicolas Zeitlinger, Julia Arnosti, David N
Published in
The Journal of biological chemistry
After a COVID-related hiatus, the fifth biennial symposium on Evolution and Core Processes in Gene Regulation met at the Stowers Institute in Kansas City, Missouri July 21 to 24, 2022. This symposium, sponsored by the American Society for Biochemistry and Molecular Biology (ASBMB), featured experts in gene regulation and evolutionary biology. Topic...
Ribas de Pouplana, Lluís
Published in
The Journal of biological chemistry
Engineering new protein functionalities through the addition of noncoded amino acids is a major biotechnological endeavor that needs to overcome the natural firewalls that prevent misincorporation during protein synthesis. This field is in constant evolution driven by the discovery or design of new tools, many of which are based on archeal biology....
