Merkulova, Alona A Abdalian, Sarah Silbak, Sadiq Pinheiro, Alessandro Schmaier, Alvin H
Published in
The Journal of allergy and clinical immunology
We examined how prekallikrein (PK) activation on human microvascular endothelial cells (HMVECs) is regulated by the ambient concentration of C1 inhibitor (C1INH) and prolylcarboxypeptidase (PRCP). We sought to examine the specificity of PK activation on HMVECs by PRCP and the role of C1INH to regulate it, high-molecular-weight kininogen (HK) cleava...
Park, Jiyeon Cho, Yuri Yang, Dongchan Yang, Hanseul Lee, Daeyoup Kubo, Masato Kang, Suk-Jo
Published in
The Journal of allergy and clinical immunology
Basophils are rare but important effector cells in many allergic disorders. Contrary to their early progenitors, the terminal developmental processes of basophils where basophils gain their unique functional properties are unknown. We sought to identify a novel late-stage basophil precursor and a transcription factor regulating the terminal maturat...
Mageiros, Leonardos Megremis, Spyridon Papadopoulos, Nikolaos G
Published in
The Journal of allergy and clinical immunology
Allergic diseases can be affected by virus-host interactions and are increasingly linked with the tissue-specific microbiome. High-throughput metagenomic sequencing has offered the opportunity to study the presence of viruses as an ecologic system, namely, the virome. Even though virome studies are technically challenging conceptually and analytica...
Zhong, Bing Sun, Silu Tan, Kai Sen Ong, Hsiao Hui Du, Jintao Liu, Feng Liu, Yafeng Liu, Shixi Ba, Luo Li, Jing
...
Published in
The Journal of allergy and clinical immunology
Chronic rhinosinusitis (CRS) is an upper airway inflammation disease associated with hypoxia-mediated inflammation. The effect of hypoxia-inducible factor 1α (HIF-1α) on NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation in the pathogenesis of sinonasal mucosa is unclear. We investigated the effect and mechanism of H...
Lee-Sarwar, Kathleen A Liu, Yang-Yu Litonjua, Augusto A Weiss, Scott T
Published in
The Journal of allergy and clinical immunology
Miralda, Irina Samanas, Nyssa B Seo, Albert J Foronda, Jake S Sachen, Josie Hui, Yvonne Morrison, Shane D Oskeritzian, Carole A Piliponsky, Adrian M
Published in
The Journal of allergy and clinical immunology
Mast cell activation is critical for the development of allergic diseases. Ligation of sialic acid-binding immunoglobin-like lectins (Siglecs), such as Siglec-6, -7, and -8 as well as CD33, have been shown to inhibit mast cell activation. Recent studies showed that human mast cells express Siglec-9, an inhibitory receptor also expressed by neutroph...
Gao, Yuan Stokholm, Jakob O'Hely, Martin Ponsonby, Anne-Louise Tang, Mimi L K Ranganathan, Sarath Saffery, Richard Harrison, Leonard C Collier, Fiona Gray, Lawrence
...
Published in
The Journal of allergy and clinical immunology
The mechanisms underlying the protective effect of older siblings on allergic disease remain unclear but may relate to the infant gut microbiota. We sought to investigate whether having older siblings decreases the risk of IgE-mediated food allergy by accelerating the maturation of the infant gut microbiota. In a birth cohort assembled using an uns...
Okuyama, Hirohisa Weyand, Cornelia M Goronzy, Jörg J
Published in
The Journal of allergy and clinical immunology
Yip, Kwok Ho Chao, Jessica Coolen, Carl Pant, Harshita Kral, Anita Smith, William Schwarz, Quenten Grimbaldeston, Michele A Pitson, Stuart Lopez, Angel F
...
Published in
The Journal of allergy and clinical immunology
Mast cells (MCs) are tissue-resident immune cells that mediate IgE-dependent allergic responses. Downstream of FcεRI, an intricate network of receptor-specific signaling pathways and adaptor proteins govern MC function. The 14-3-3 family of serine-threonine phosphorylation-dependent adapter proteins are known to organize intracellular signaling. Ho...
Moreno-Sabater, Alicia Sterlin, Delphine Imamovic, Lejla Bon, Fabienne Normand, Anne-Cecile Gonnin, Cecile Gazzano, Marianne Bensalah, Merieme Dorgham, Karim Ben Salah, Elyes
...
Published in
The Journal of allergy and clinical immunology
Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether human IgA-deficiency is associated with gut fungal dysbiosis remains unknown. Our goal was to study the impact of IgA on gut mycobiota ecology. The Fungi-Flow method was used to characterize fecal, systemic...
