Published in
The Journal of Urology
Abstract Purpose Undescended testis (UDT) leads to infertility and malignancy resulting from aberrant germ cell (GC) development. Androgens are proposed to control early GC development during the transient postnatal surge of gonadotropins and androgen, known as mini-puberty. We aim to assess the effect of androgen receptor on perinatal GC developme...
Published in
The Journal of Urology
Abstract Purpose Previous studies have demonstrated lower prostate-specific antigen (PSA) concentrations in men with type 2 diabetes (T2DM), paralleling the reported lower prevalence of prostate cancer among diabetic men. Data on PSA in men with type 1 diabetes (T1DM), in whom insulin and obesity profiles differ from those in T2DM, are lacking. The...
Published in
The Journal of Urology
Abstract Purpose Men diagnosed with atypical small acinar proliferation (ASAP) are counseled to undergo early re-biopsy, as their risk of prostate cancer (PCa) is high. However, random re-biopsies may not re-sample areas of concern. Magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion-guided biopsy offers an opportunity to accurately...
Published in
The Journal of Urology
Purpose Conventional platinum based chemotherapy for advanced urothelial carcinoma is plagued by common resistance to this regimen. Several studies implicate the EGFR family of RTKs in urothelial carcinoma progression and chemoresistance. Many groups have investigated the effects of inhibitors of this family in patients with urothelial carcinoma. T...
Published in
The Journal of Urology
Purpose Prostate specific antigen sensitivity increases with lower threshold values but with a corresponding decrease in specificity. Magnetic resonance imaging/ultrasound targeted biopsy detects prostate cancer more efficiently and at higher grade than standard 12-core transrectal ultrasound biopsy but the optimal population for its use is not wel...
Published in
The Journal of Urology
Purpose Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain a...
Published in
The Journal of Urology
Purpose Nephron sparing surgery is the standard of care for many adults with renal tumors and has been described in some children with Wilms tumor. However, beyond case series the data concerning nephron sparing surgery application and outcomes in patients with Wilms tumor are scarce. We examined nephron sparing surgery outcomes and factors associa...
Published in
The Journal of Urology
Purpose Exposure of urothelial carcinoma cells to bacillus Calmette-Guérin affects cellular redox status and tumor cell biology but the mechanism(s) remain unclear. We examined free radical production by bacillus Calmette-Guérin in tumor cells in response to the bacillus using global profiling of reactive oxygen species/reactive nitrogen species. T...
Handa, Rajash K Evan, Andrew P Connors, Bret A Johnson, Cynthia D Liu, Ziyue Alloosh, Mouhamad Sturek, Michael Evans-Molina, Carmella Mandeville, Jessica A Gnessin, Ehud
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Published in
The Journal of urology
The metabolic syndrome status of pigs treated with shock wave lithotripsy was unchanged 2 months after kidney treatment with 2,000 high amplitude shock waves or overtreatment with 4,000 high amplitude shock waves. These findings do not support a single shock wave lithotripsy treatment of the kidney as a risk factor for the onset of diabetes mellitu...
Redshaw, Jeffrey D Elliott, Sean P Rosenstein, Daniel I Erickson, Bradley A Presson, Angela P Conti, Simon L McAdams, Sean Nguyen, Andrew West, Jeremy M Brant, William O
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Published in
The Journal of urology
Patients with continent cutaneous ileal cecocystoplasty undergo fewer interventions to maintain the catheterizable channel than patients with a tunneled continent catheterizable channel.
