Baruchin, Liad J. Alleman, Matteo Schröder, Sylvia
Published in
The Journal of Neuroscience
The processing of sensory input is constantly adapting to behavioral demands and internal states. The drive to obtain reward, e.g., searching for water when thirsty, is a strong behavioral demand and associating the reward with its source, a certain environment or action, is paramount for survival. Here, we show that water reward increases subseque...
Giordano, Nadia Alia, Claudia Fruzzetti, Lorenzo Pasquini, Maria Palla, Giulia Mazzoni, Alberto Micera, Silvestro Fogassi, Leonardo Bonini, Luca Caleo, Matteo
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Published in
The Journal of Neuroscience
Planning and execution of voluntary movement depend on the contribution of distinct classes of neurons in primary motor and premotor areas. However, timing and pattern of activation of GABAergic cells during specific motor behaviors remain only partly understood. Here, we directly compared the response properties of putative pyramidal neurons (PNs)...
Wisniewski, David Braem, Senne González-García, Carlos De Houwer, Jan Brass, Marcel
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fear learning allows us to identify and anticipate aversive events and adapt our behavior accordingly. This is often thought to rely on associative learning mechanisms where an initially neutral conditioned stimulus (CS) is repeatedly paired with an aversive unconditioned stimulus (US), eventually leading to the CS also being perceived as aversive ...
Schregel, Katharina Heinz, Lennart Hunger, Jessica Pan, Chenchen Bode, Julia Fischer, Manuel Sturm, Volker Venkataramani, Varun Karimian-Jazi, Kianush Agardy, Dennis A
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Glioblastoma is the most common malignant primary brain tumor with poor overall survival. Magnetic resonance imaging (MRI) is the main imaging modality for glioblastoma but has inherent shortcomings. The molecular and cellular basis of MR signals is incompletely understood. We established a ground truth-based image analysis platform to coregister M...
Turner, William Blom, Tessel Hogendoorn, Hinze
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hierarchical predictive coding networks are a general model of sensory processing in the brain. Under neural delays, these networks have been suggested to naturally generate oscillatory activity in approximately the α frequency range (∼8-12 Hz). This suggests that α oscillations, a prominent feature of EEG recordings, may be a spectral "fingerprint...
Bouchet, Courtney A McPherson, Kylie B Coutens, Basile Janowsky, Aaron Ingram, Susan L
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cannabinoid-targeted pain therapies are increasing with the expansion of cannabis legalization, however, their efficacy may be limited by pain-induced adaptations in the cannabinoid system. Cannabinoid receptor subtype 1 (CB1R) inhibition of spontaneous, GABAergic miniature IPSCs (mIPSCs) and evoked IPSCs (eIPSCs) in the ventrolateral periaqueducta...
Colgan, Lesley A Parra-Bueno, Paula Holman, Heather L Tu, Xun Jain, Anant Calubag, Mariah F Misler, Jaime A Gary, Chancellor Oz, Goksu Suponitsky-Kroyter, Irena
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The activity-dependent plasticity of synapses is believed to be the cellular basis of learning. These synaptic changes are mediated through the coordination of local biochemical reactions in synapses and changes in gene transcription in the nucleus to modulate neuronal circuits and behavior. The protein kinase C (PKC) family of isozymes has long be...
Guntupalli, Sumasri Park, Pojeong Han, Dae Hee Zhang, Lingrui Yong, Xuan Ling Hilary Ringuet, Mitchell Blackmore, Daniel G Jhaveri, Dhanisha J Koentgen, Frank Widagdo, Jocelyn
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Activity-dependent changes in the number of AMPA-type glutamate receptors (AMPARs) at the synapse underpin the expression of LTP and LTD, cellular correlates of learning and memory. Post-translational ubiquitination has emerged as a key regulator of the trafficking and surface expression of AMPARs, with ubiquitination of the GluA1 subunit at Lys-86...
Ireton, Kyle E Xing, Xiaoming Kim, Karam Weiner, Justin C Jacobi, Ariel A Grover, Aarushi Foote, Molly Ota, Yusuke Berman, Robert Hanks, Timothy
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Widespread release of norepinephrine (NE) throughout the forebrain fosters learning and memory via adrenergic receptor (AR) signaling, but the molecular mechanisms are largely unknown. The β2 AR and its downstream effectors, the trimeric stimulatory Gs-protein, adenylyl cyclase (AC), and the cAMP-dependent protein kinase A (PKA), form a unique sign...
Souza, George M P R Stornetta, Daniel S Shi, Yingtang Lim, Eunu Berry, Faye E Bayliss, Douglas A Abbott, Stephen B G
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Respiratory chemoreceptor activity encoding arterial Pco2 and Po2 is a critical determinant of ventilation. Currently, the relative importance of several putative chemoreceptor mechanisms for maintaining eupneic breathing and respiratory homeostasis is debated. Transcriptomic and anatomic evidence suggests that bombesin-related peptide Neuromedin-B...