Miracca, Giulia Anuncibay-Soto, Berta Tossell, Kyoko Yustos, Raquel Vyssotski, Alexei L Franks, Nicholas P Wisden, William
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The lateral preoptic (LPO) hypothalamus is a center for NREM and REM sleep induction and NREM sleep homeostasis. Although LPO is needed for NREM sleep, we found that calcium signals were, surprisingly, highest in REM sleep. Furthermore, and equally surprising, NMDA receptors in LPO were the main drivers of excitation. Deleting the NMDA receptor Glu...
Glitz, Leonie Juechems, Keno Summerfield, Christopher Garrett, Neil
Published in
The Journal of Neuroscience
Effective planning involves knowing where different actions take us. However, natural environments are rich and complex, leading to an exponential increase in memory demand as a plan grows in depth. One potential solution is to filter out features of the environment irrelevant to the task at hand. This enables a shared model of transition dynamics ...
Sen, Sriparna Khalsa, Nanak Nihal Tong, Ningcong Ovadia-Caro, Smadar Wang, Xiaoying Bi, Yanchao Striem-Amit, Ella
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Visual cortex organization is highly consistent across individuals. But to what degree does this consistency depend on life experience, in particular sensory experience? In this study, we asked whether visual cortex reorganization in congenital blindness results in connectivity patterns that are particularly variable across individuals, focusing on...
Son, Seoyoung Manjila, Steffy B. Newmaster, Kyra T. Wu, Yuan-ting Vanselow, Daniel J. Ciarletta, Matt Anthony, Todd E. Cheng, Keith C. Kim, Yongsoo
Published in
The Journal of Neuroscience
Oxytocin (Oxt) neurons regulate diverse physiological responses via direct connections with different neural circuits. However, the lack of comprehensive input-output wiring diagrams of Oxt neurons and their quantitative relationship with Oxt receptor (Oxtr) expression presents challenges to understanding circuit-specific Oxt functions. Here, we es...
Rubin, Daniel B Hosman, Tommy Kelemen, Jessica N Kapitonava, Anastasia Willett, Francis R Coughlin, Brian F Halgren, Eric Kimchi, Eyal Y Williams, Ziv M Simeral, John D
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Consolidation of memory is believed to involve offline replay of neural activity. While amply demonstrated in rodents, evidence for replay in humans, particularly regarding motor memory, is less compelling. To determine whether replay occurs after motor learning, we sought to record from motor cortex during a novel motor task and subsequent overnig...
Abbah, Joseph Vacher, Claire-Marie Goldstein, Evan Z Li, Zhen Kundu, Srikanya Talbot, Brooke Bhattacharya, Surajit Hashimoto-Torii, Kazue Wang, Li Banerjee, Payal
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neonatal brain injury renders the developing brain vulnerable to oxidative stress, leading to cognitive deficit. However, oxidative stress-induced damage to hippocampal circuits and the mechanisms underlying long-term changes in memory and learning are poorly understood. We used high oxygen tension or hyperoxia (HO) in neonatal mice of both sexes t...
Morito, Yusuke Murata, Tsutomu
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Neural substrates of evidence accumulation have been a central issue in decision-making studies because of the prominent success of the accumulation model in explaining a wide range of perceptual decision making. Since accumulation-shaped activities have been found in multiple brain regions, which are called accumulators, questions regarding functi...
Richard, Mélisande Doubková, Karolína Nitta, Yohei Kawai, Hiroki Sugie, Atsushi Tavosanis, Gaia
Published in
The Journal of Neuroscience
In human neurodegenerative diseases, neurons undergo axonal degeneration months to years before they die. Here, we developed a system modeling early degenerative events in Drosophila adult photoreceptor cells. Thanks to the stereotypy of their axonal projections, this system delivers quantitative data on sporadic and progressive axonal degeneration...
Patai, E Zita Foltynie, Thomas Limousin, Patricia Akram, Harith Zrinzo, Ludvic Bogacz, Rafal Litvak, Vladimir
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Making accurate decisions often involves the integration of current and past evidence. Here, we examine the neural correlates of conflict and evidence integration during sequential decision-making. Female and male human patients implanted with deep-brain stimulation (DBS) electrodes and age-matched and gender-matched healthy controls performed an e...
Wislowska, Malgorzata Klimesch, Wolfgang Jensen, Ole Blume, Christine Schabus, Manuel
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Recent research revealed a surprisingly large range of cognitive operations to be preserved during sleep in humans. The new challenge is therefore to understand functions and mechanisms of processes, which so far have been mainly investigated in awake subjects. The current study focuses on dynamic changes of brain oscillations and connectivity patt...
