Marlene Buchebner Thomas Pfeifer Nora Rathke Prakash G. Chandak Achim Lass Renate Schreiber Adelheid Kratzer Robert Zimmermann Wolfgang Sattler Harald Koefeler
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Published in
The Journal of Lipid Research
Cholesteryl ester (CE) accumulation in macrophages represents a crucial event during foam cell formation, a hallmark of atherogenesis. Here we investigated the role of two previously described CE hydrolases, hormone-sensitive lipase (HSL) and KIAA1363, in macrophage CE hydrolysis. HSL and KIAA1363 exhibited marked differences in their abilities to ...
Rongsong Li Wendy Chen Rolando Yanes Sangderk Lee Judith A Berliner
Published in
The Journal of Lipid Research
Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) is present in oxidative modified LDL and accumulates in lesions of many chronic inflammatory diseases, such as atherosclerosis. In a microarray study, OxPAPC has been demonstrated to modulate the expression of >700 genes in human aortic endothelial cells. We found that the ...
Heikkila, Re Deamer, Dw Cornwell, Dg
Published in
The Journal of Lipid Research
The contraction or decrease in area of fatty acid monolayers maintained at a constant surface pressure of 16 dynes/cm was studied as a function of fatty acid chain length, unsaturation, temperature, and the hydrogen ion concentration in the subphase. The data were consistent with the hypothesis that fatty acid solution from the monolayer into the s...
David Deamer Meek, Dw Cornwell, Dg
Published in
The Journal of Lipid Research
Interactions between alkaline earth ions and the carboxylate ligand in a stearic acid surface film have been investigated by IR spectrophotometry and surface chemical procedures. The frequency and shape of the carboxylate absorption band and the effect of hydration and pH on band characteristics suggest that beryllium, magnesium, and calcium ions f...
Hane Lee Zhang, Y Lee, Fy Stanley F. Nelson Gonzalez, Fj Edwards, Pa
Published in
The Journal of Lipid Research
Expression of the farnesoid X receptor (FXR; NR1H4) is limited to the liver, intestine, kidney, and adrenal gland. However, the role of FXR in the latter two organs is unknown. In the current study, we performed microarray analysis using RNA from H295R cells infected with constitutively active FXR. Several putative FXR target genes were identified,...
Deamer, Dw Meek, Dw Cornwell, Dg
Published in
The Journal of Lipid Research
Interactions between alkaline earth ions and the carboxylate ligand in a stearic acid surface film have been investigated by IR spectrophotometry and surface chemical procedures. The frequency and shape of the carboxylate absorption band and the effect of hydration and pH on band characteristics suggest that beryllium, magnesium, and calcium ions f...
Heikkila, Re David Deamer Cornwell, Dg
Published in
The Journal of Lipid Research
The contraction or decrease in area of fatty acid monolayers maintained at a constant surface pressure of 16 dynes/cm was studied as a function of fatty acid chain length, unsaturation, temperature, and the hydrogen ion concentration in the subphase. The data were consistent with the hypothesis that fatty acid solution from the monolayer into the s...
