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Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-as...

Published in The Journal of infectious diseases

Cryptococcal capsule size ex vivo is an important contributor to virulence in human cryptococcal meningitis.

A Randomized Comparison of Dihydroartemisinin-Piperaquine and Artesunate-Amodiaquine Combined with Primaquine for Radica...

Published in The Journal of Infectious Diseases

Background. High prevalence of chloroquine resistant P. vivax in Indonesia, has shifted first-line treatment to artemisinin-based combination therapies (ACTs), combined with primaquine for radical cure. Which combination is most effective and safe, needs to be established.Methods. We conducted a prospective open-label randomized comparison of 14 da...

Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretr...

Published in The Journal of Infectious Diseases

Regardless of concomitant nevirapine vs. efavirenz, therapy duration, or subtype, tenofovir was more likely than zidovudine to retain antiviral activity following first-line d4T therapy.

Tuberculosis and HIV control in sub-Saharan African prisons: "thinking outside the prison cell".

Published in The Journal of Infectious Diseases

Tuberculosis is one of the fastest-growing epidemics in prison populations in sub-Saharan Africa (SSA), constituting a threat to both inmates and the wider community. Various factors have contributed to the breakdown of tuberculosis control in prison facilities in SSA, including slow and insensitive diagnostics, failing prison infrastructure, inade...

A potential role of indoleamine 2,3-dioxygenase-specific T cells in leishmania vaccination.

Published in The Journal of infectious diseases

Lectin switching during dengue virus infection.

Published in The Journal of infectious diseases

Dengue virus receptors are relatively poorly characterized, but there has been recent interest in 2 C-type lectin molecules, dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN) and its close homologue liver/lymph node-specific ICAM-3-grabbing integrin (L-SIGN), which can both bind dengue and promote inf...

Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-...

Published in The Journal of infectious diseases

In adults and elderly adults, AS03(A)-adjuvanted H5N1 candidate vaccine was highly immunogenic for A/Indonesia/05/2005, with cross-reactivity against A/Vietnam/1194/2004. Temporary injection site reactions were more frequent with H5N1 vaccine than placebo, although the H5N1 vaccine was well tolerated overall. Clinical Trials Registration. NCT006169...

Substantially reduced pre-patent parasite multiplication rates are associated with naturally acquired immunity to Plasmo...

Published in The Journal of Infectious Diseases

Naturally acquired immunity to Plasmodium falciparum's asexual blood stage reduces parasite multiplication at microscopically detectable densities. The effect of natural immunity on initial prepatent parasite multiplication during the period following a new infection has been uncertain, contributing to doubt regarding the utility of experimental ch...

Marked reduction in prevalence of malaria parasitemia and anemia in HIV-infected pregnant women taking cotrimoxazole wit...

Published in The Journal of infectious diseases

In HIV-infected pregnant women, daily CTX was associated with reduced malaria parasitemia and anemia compared with SP-IPTp. CTX plus SP-IPTp was associated with further reduction in malaria parasitemia but toxicity was not fully assessed.

Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positi...

Published in The Journal of infectious diseases

Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitr...