Wu, Chenzhou Cai, Xiaomin Wang, Ying Rodriguez, Carlos D Zoaldi, Giorgia Herrmann, Lydia Huang, Chun-Yuh Wang, Xiaoqiong Sanghvi, Viraj R Lu, Rongze O
...
Published in
The Journal of biological chemistry
The Hippo signaling is instrumental in regulating organ size, regeneration, and carcinogenesis. The cytoskeleton emerges as a primary Hippo signaling modulator. Its structural alterations in response to environmental and intrinsic stimuli control Hippo signaling pathway activity. However, the precise mechanisms underlying the cytoskeleton regulatio...
Kanefsky, Joice Basse, Mary Sokei, Judith di Martino, Orsola Valin, Liana Jaspers, Yorrick Martinez, Esteban Huhn, Jacklyn Di Marcantonio, Daniela Magee, Jeffrey A
...
Published in
The Journal of biological chemistry
The role of polyunsaturated fatty acid (PUFA) biosynthesis in acute myeloid leukemia (AML) remains largely undefined. A comparative expression analysis of 35 genes encoding fatty acid biosynthesis enzymes showed that fatty acid desaturase 1 (FADS1) was highly expressed across multiple AML subtypes relative to healthy controls and that elevated FADS...
Benchoam, Dayana Cuevasanta, Ernesto Roman, Joseph V Banerjee, Ruma Alvarez, Beatriz
Published in
The Journal of biological chemistry
Persulfides (RSSH/RSS-) participate in sulfur metabolism and are proposed to transduce hydrogen sulfide (H2S) signaling. Their biochemical properties are poorly understood. Herein, we studied the acidity and nucleophilicity of several low molecular weight persulfides using the alkylating agent, monobromobimane. The different persulfides presented s...
Crickard, J. Brooks Kwon, Youngho Sung, Patrick Greene, Eric C.
Published in
The Journal of Biological Chemistry
Uchendu, Chioma G. Guan, Ziqiang Klein, Eric A.
Published in
The Journal of Biological Chemistry
Sphingolipids are produced by nearly all eukaryotes where they play significant roles in cellular processes such as cell growth, division, programmed cell death, angiogenesis, and inflammation. While it was previously believed that sphingolipids were quite rare among bacteria, bioinformatic analysis of the recently identified bacterial sphingolipid...
Skurat, Alexander V. Segvich, Dyann M. Contreras, Christopher J. Hu, Yueh-Chiang Hurley, Thomas D. DePaoli-Roach, Anna A. Roach, Peter J.
Published in
The Journal of Biological Chemistry
Lafora disease (LD) is an autosomal recessive myoclonus epilepsy with onset in the teenage years leading to death within a decade of onset. LD is characterized by the overaccumulation of hyperphosphorylated, poorly branched, insoluble, glycogen-like polymers called Lafora bodies. The disease is caused by mutations in either EPM2A , encoding laforin...
Hong, Sujin Lee, Hyeon-geun Huh, Won-Ki
Published in
The Journal of Biological Chemistry
The stability of ribosomal DNA (rDNA) is maintained through transcriptional silencing by the NAD+-dependent histone deacetylase Sir2 in Saccharomyces cerevisiae . Alongside proteostasis, rDNA stability is a crucial factor regulating the replicative lifespan of S. cerevisiae . The unfolded protein response (UPR) is induced by misfolding of proteins ...
Steenberge, Laura H. Rogers, Sean Sung, Andrew Y. Fan, Jing Pagliarini, David J.
Published in
The Journal of Biological Chemistry
Coenzyme Q10 (CoQ10) is an important cofactor and antioxidant for numerous cellular processes, and its deficiency has been linked to human disorders including mitochondrial disease, heart failure, Parkinson’s disease, and hypertension. Unfortunately, treatment with exogenous CoQ10 is often ineffective, likely due to its extreme hydrophobicity and h...
Msekela, Deborah J. Sine, Steven M.
Published in
The Journal of Biological Chemistry
We describe molecular-level functional changes in the α4β2 nicotinic acetylcholine receptor by a leucine residue insertion in the M2 transmembrane domain of the α4 subunit associated with sleep-related hyperkinetic epilepsy. Measurements of agonist-elicited single-channel currents reveal the primary effect is to stabilize the open channel state, wh...
McMillan, Sarah D. Keck, James L.
Published in
The Journal of Biological Chemistry
DNA replication in Escherichia coli starts with loading of the replicative helicase, DnaB, onto DNA. This reaction requires the DnaC loader protein, which forms a 6:6 complex with DnaB and opens a channel in the DnaB hexamer through which single-stranded DNA is thought to pass. During replication, replisomes frequently encounter DNA damage and nucl...
