Raihan Shah Mahmud M. Markelova S. Malanin V. Ulyanova O. Ilinskaya
Published in
The FEBS Journal
Binase is an extracellular ribonuclease from Bacillus pumiluswhich shows antiviral and antitumor activities in cell cultures.However, the action of binase on intracellular functions and pro-cesses has not yet been identified. Here, for the first time wereport the whole transcriptome analysis of binase-treated humanlung adenocarcinoma epithelial A549 ...
Raihan Shah Mahmud L. Mindubaeva Vera Ulyanova L. Khazieva H. Vargas Olga Ilinskaya
Published in
The FEBS Journal
Guanyl-preffering ribonucleases (RNases) which are secreted byBacillus species were shown to exhibit antiviral effect on influen-za, murrain, rabbies viruses in vitro and in vivo. However, theirpotential in defense of bacterial population against bacteriophageinfection has not yet been studied.Using microbiological and virological methods we have is...
Arbabian, Atousa Brouland, Jean-Philippe Apáti, Ágota Pászty, Katalin Hegedűs, Luca Enyedi, Ágnes Christine Chomienne Papp, Béla
Published in
The FEBS Journal
Cellular calcium signaling plays important roles in several signal transduction pathways that control proliferation, differentiation and apoptosis. In epithelial cells calcium signaling is initiated mainly by calcium release from endoplasmic-reticulum-associated intracellular calcium pools. Because calcium is accumulated in the endoplasmic reticulu...
Maïga, Oumou Philippe, Monique Kotelevets, Larissa Chastre, Eric Samira Benadda Pidard, Dominique Vranckx, Roger Walch, Laurence
Published in
The FEBS Journal
Human disc-large homolog (hDlg), also known as synapse-associated protein 97, is a scaffold protein, a member of the membrane-associated guanylate kinase family, implicated in neuronal synapses and epithelial-epithelial cell junctions whose expression and function remains poorly characterized in most tissues, particularly in the vasculature. In hum...
Malka, Florence Dairou, Julien Ragunathan, Nilusha Jean-Marie Dupret Fernando Rodrigues-Lima
Published in
The FEBS Journal
Disulfiram has been used for decades to treat alcoholism. Its therapeutic effect is thought to be mediated by the irreversible inhibition of aldehyde dehydrogenase. Recent reports have indicated new therapeutic uses of disulfiram, in particular in human cancers. Although the biochemical mechanisms that underlie these effects remain largely unknown,...
Gagliardo, Bruno Faye, Audrey Jaouen, Maryse Deschemin, Jean-Christophe Canonne-Hergaux, François Sophie Vaulont Marie-Agnès Sari
Published in
The FEBS Journal
Hepcidin is a liver produced cysteine-rich peptide hormone that acts as the central regulator of body iron metabolism. Hepcidin is synthesized under the form of a precursor, prohepcidin, which is processed to produce the biologically active mature 25 amino acid peptide. This peptide is secreted and acts by controlling the concentration of the membr...
Rebholz, Heike Panasyuk, Ganna Fenton, Timothy Ivan Nemazanyy Valovka, Taras Flajolet, Marc Ronnstrand, Lars Stephens, Len West, Andrew Gout, Ivan T
...
Published in
The FEBS Journal
Ribosomal protein S6 kinase (S6K) is activated by an array of mitogenic stimuli and is a key player in the regulation of cell growth. The activation process of S6 kinase involves a complex and sequential series of multiple Ser/Thr phosphorylations and is mainly mediated via phosphatidylinositol 3-kinase (PI3K)-3-phosphoinositide-dependent protein k...
