What good is COVID ?
Published in The FASEB Journal
Menstrual experiences after COVID‐19 vaccination in a non‐menstruating gender diverse sample
Published in The FASEB Journal
After COVID‐19 vaccination a number of currently and formerly menstruating people reported changes in menstrual bleeding and menstrual symptoms. Media highlighted these experiences, but much of the focus was on changes in regularly menstruating cis‐gendered women and unnecessary concerns about fertility. This was despite ample evidence of vaccine s...
Ephrin Ligands are Upregulated in the Saliva of SARS‐CoV‐2 Infected Patients
Published in The FASEB Journal
Background Patients infected with SARS‐CoV‐2 may develop severe lung disease characterized by respiratory distress, systemic thrombosis, or death. Molecular mechanisms responsible for severe cases of COVID‐19 remain unclear. We investigated the role of the Eph family r eceptor‐ in teracting ligands (ephrin‐A1 and ephrin‐B2) in COVID‐19 patients. Ep...
Using Q-Methodology to Evaluate Student Perceptions of Online Anatomy in the Time of COVID-19.
Published in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Since the seventeenth century, the primary approach to teaching anatomy has involved hands-on learning using cadaveric specimens. However, the ability to use this long-standing tradition was curtailed in the 2020-2021 school year due to the COVID-19 pandemic. Many institutions closed physical classrooms entirely, launching experiential courses, suc...
Elevated 5‐hydroxytryptamine in COVID‐19 Stimulates ANO1 Mediated Cl Secretion in Lung & Intestinal Epithelial Cells
Published in The FASEB Journal
Earlier studies demonstrated that blood 5‐hydroxytryptamine (5‐HT) is elevated in patients with COVID‐19‐associated diarrhea with higher severity of symptoms. We hypothesize that disruption of vectorial Cl transport by 5‐HT may be critical in determining the alveolar flooding and abnormalities in intestinal Cl secretion through stimulation of anoct...
Iatrogenic dehydration drives organic osmolyte production in critical COVID‐19
Published in The FASEB Journal
Fluid removal with concomitant dehydration is a common treatment strategy in acute respiratory distress syndrome (ARDS). We have previously shown that iatrogenic dehydration during treatment in the intensive care unit (ICU) is associated with a shift to organic osmolyte production in the general ICU population. In this study we investigate the deve...
Binding mechanisms of Shikonin derivatives targeting SARS-CoV-2 main protease.
Published in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shikonin, a well-known bioactive chemical present in the dried roots of Lithospermum erthrorhizon, is recognized for its broad-spectrum activities against cancer, oxidative stress, inflammation, virus, and anti-COVID-19 agent. In recent discovery, the crystallographic study of Shikonin bound Main protease (Mpro ) of SARS CoV-2 revealed different co...
SARS-CoV-2 and Hippo Signaling Pathway: A Potential Therapeutic Target.
Published in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic, which causes respiratory failure and damage to multiple organ systems. Emergence of new variants of concern (VOCs), including Omicron can potentially render the current vaccines ineffective. However, our understanding of COVID-19 pathophysiology and molecular basis of SARS-CoV-2 infection...
Anatomical Gift Programs Continue to Meet Donor Demands of Anatomy Educators During the COVID-19 Pandemic: Here's How.
Published in FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Schools of higher education across the US closed all operations and in-person classes during the COVID -19 pandemic, significantly affecting laboratory-based anatomy dissection courses and the anatomical gift programs (AGP) that support them. The purpose of this study was to investigate how the COVID-19 pandemic affected AGP operations in the US. T...
Alcohol exacerbates SARS‐CoV‐2 ‐induced ARDS in mice
Published in The FASEB Journal
SARS‐CoV‐2 – induced COVID‐19 causes acute respiratory distress syndrome (ARDS) and multiorgan failure. COVID‐19 can also cause psycho‐social problems, including increased alcohol consumption and consequent complications. Alcohol abuse is recognized as an independent factor that increases by three‐ to four‐fold the incidence of ARDS, a severe form ...
