Margetts-Smith, Gabriella Macnaghten, Anastasia I Brebner, Leonie S Ziminski, Joseph J Sieburg, Meike C Grimm, Jeffrey Crombag, Hans S Koya, Eisuke
Published in
The European journal of neuroscience
Exposure to environmental enrichment can modify the impact of motivationally relevant stimuli. For instance, previous studies in rats have shown that even a brief, acute (~1 day), but not chronic, exposure to environmentally enriched (EE) housing attenuates instrumental lever pressing for sucrose-associated cues in a conditioned reinforcement setup...
Kilinc, Erkan Torun, Ibrahim Ethem Cetinkaya, Ayhan Tore, Fatma
Published in
The European journal of neuroscience
Neuroinflammation plays a key role in the pathogenesis of epilepsy, but the underlying mechanisms are not well understood. Mast cells are multifunctional immune cells that are also activated by stress. The effects of activated mast cells on epileptogenesis are not yet known. This study investigated the effects and mechanisms of compound 48/80-stimu...
Darch, Henry T Collins, Michael K O'Riordan, Kenneth J Cryan, John F
Published in
The European journal of neuroscience
Germ-free rodents, raised in the absence of a measurable gut microbiome, have been a key model to study the microbiome-gut-brain axis. Germ-free mice exhibit marked behavioural and neurochemical differences to their conventionally raised counterparts. It is as yet unclear how these neurochemical differences lead to the behavioural differences. Here...
Schindler, Sebastian Wolf, Maren-Isabel Bruchmann, Maximilian Straube, Thomas
Published in
The European journal of neuroscience
Emotional facial expressions elicit distinct increased early electrophysiological responses. Many studies report even emotional modulations of very early sensory processing at about 80 and 100 ms after stimulus presentation, indexed by the P1. These early effects are often interpreted to index differential responses to biologically relevant express...
Peters, Kate Z Young, Andrew M J McCutcheon, James E
Published in
The European journal of neuroscience
Disruptions in attention, salience and increased distractibility are implicated in multiple psychiatric conditions. The ventral tegmental area (VTA) is a potential site for converging information about external stimuli and internal states to be integrated and guide adaptive behaviours. Given the dual role of dopamine signals in both driving ongoing...
Gaillard, Alexandra Fehring, Daniel J Rossell, Susan L
Published in
The European journal of neuroscience
The number of studies investigating sex differences in executive functions, particularly those using human functional neuroimaging techniques, has risen dramatically in the past decade. However, the influences of sex on executive function are still underexplored and poorly characterized. To address this, we conducted a systematic literature review ...
Lengvenyte, Aiste Conejero, Ismael Courtet, Philippe Olié, Emilie
Published in
The European journal of neuroscience
Suicidal behaviour is a multifaceted phenomenon that concerns all human populations. It has been suggested that a complex interaction between the individual genetic profile and environmental factors throughout life underlies the pathophysiology of suicidal behaviour. Although epidemiological and genetic studies suggest the existence of a genetic co...
Umschweif, Gali Greengard, Paul Sagi, Yotam
Published in
The European journal of neuroscience
Extensive preclinical research has been conducted in recent years to reveal the cell types, neuronal circuits and molecular and morphological changes implicated in the function of the dentate gyrus in depression. This was profoundly facilitated by the emergence of methods such as gene targeting, neuronal cell activity manipulation, including optoge...
Duman, Ronald S Deyama, Satoshi Fogaça, Manoela Viar
Published in
The European journal of neuroscience
The pathophysiology and treatment of depression have been the focus of intense research and while there is much that remains unknown, modern neurobiological approaches are making progress. This work demonstrates that stress and depression are associated with atrophy of neurons and reduced synaptic connectivity in brain regions such as the hippocamp...
Boda, Enrica
Published in
The European journal of neuroscience
Depressive disorders are complex, multifactorial disorders that have been traditionally attributed exclusively to neuronal abnormalities. However, recent studies have increased our understanding of the contribution of glial cells-and particularly of oligodendroglia-to the pathogenesis and treatment outcome of depression and stress-related disorders...
