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SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

Published in The EMBO Journal

SARS‐CoV‐2 infection causes broad‐spectrum immunopathological disease, exacerbated by inflammatory co‐morbidities. A better understanding of mechanisms underpinning virus‐associated inflammation is required to develop effective therapeutics. Here we discover that SARS‐CoV‐2 replicates rapidly in lung epithelial cells despite triggering a robust inn...

Programmable C-to-U RNA editing using the human APOBEC3A deaminase.

Published in The EMBO journal

The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains

Published in The EMBO Journal

Binding of K63‐linked ubiquitin chains via a tightly‐linked accessory domains allows two homologous human and yeast E2 enzymes to add further K48‐linked moieties and build branched conjugates.

Syncytia formation by SARS‐CoV‐2‐infected cells

Published in The EMBO Journal

The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo

Published in The EMBO Journal

Opposing activities of IFITM proteins in SARS‐CoV‐2 infection

Published in The EMBO Journal

Interferon‐induced transmembrane proteins (IFITMs) restrict infections by many viruses, but a subset of IFITMs enhance infections by specific coronaviruses through currently unknown mechanisms. We show that SARS‐CoV‐2 Spike‐pseudotyped virus and genuine SARS‐CoV‐2 infections are generally restricted by human and mouse IFITM1, IFITM2, and IFITM3, us...

LRRK 2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK ‐mediated ubiquitination pathway

Published in The EMBO Journal

Optimal sidestepping of intraflagellar transport kinesins regulates structure and function of sensory cilia

Published in The EMBO Journal

α‐Actinin‐1 promotes activity of the L‐type Ca 2+ channel Ca v1.2

Published in The EMBO Journal

Domain structure of secretin PulD revealed by limited proteolysis and electron microscopy.

Published in The EMBO journal

Secretins, a superfamily of multimeric outer membrane proteins, mediate the transport of large macromolecules across the outer membrane of Gram-negative bacteria. Limited proteolysis of secretin PulD from the Klebsiella oxytoca pullulanase secretion pathway showed that it consists of an N-terminal domain and a protease-resistant C-terminal domain t...