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Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1...

Published in The EMBO Journal

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Published in The EMBO Journal

Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.

Published in The EMBO journal

Exposure of mitochondrial DNA (mtDNA) to the cytosol activates innate immune responses. But the mechanisms by which mtDNA crosses the inner mitochondrial membrane are unknown. Here, we found that the inner mitochondrial membrane protein prohibitin 1 (PHB1) plays a critical role in mtDNA release by regulating permeability across the mitochondrial in...

Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis.

Published in The EMBO journal

The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells (NSCs) is a major challenge. Here, we focused on elucidating the transcriptional landscape of murine embryonic...

Mitochondria and peroxisomes are NIXed for clearance.

Published in The EMBO journal

A recent report shows that the iron chelator DFP induces both mitophagy and pexophagy in a BNIP3/NIX-dependent manner. Previously known as a mitophagy receptor, NIX was also independently localized to peroxisomes to promote pexophagy in several physiological conditions, illustrating the significance of this novel function. Published 2022. This arti...

E-cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities.

Published in The EMBO journal

Individual cells within de novo polarising tubes and cavities must integrate their forming apical domains into a centralised apical membrane initiation site (AMIS). This is necessary to enable organised lumen formation within multi-cellular tissue. Despite the well-documented importance of cell division in localising the AMIS, we have found a divis...

Calnexin reveals a sugar-free taste within the lipid bilayer.

Published in The EMBO journal

Maturation of membrane proteins is complicated by the need to fold in three distinct environments. While much is known about folding in the two aqueous milieus constituted by cytoplasm and ER lumen, our knowledge of the folding, arrangement, and quality control of transmembrane regions within the lipid bilayer, and its facilitation by molecular cha...

LUBAC and NF-κB trigger a nuclear response from mitochondria.

Published in The EMBO journal

Mitochondria are key signaling hubs for innate immune responses. In this issue, Wu et al (2022) report that remodeling of the outer mitochondrial membrane by the linear ubiquiting chain assembly complex (LUBAC) facilitates transport of activated NF-κB to the nucleus in response to TNF signaling. © 2022 The Authors.

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.

Published in The EMBO journal

Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are repaired by the ESCRT machinery. Here, we describe an additional mechanism for lysosome repair that is activated independently of ESCRT recruitment. Lipidomic analyses showed increases in lysosomal phosphatidylserine and cholesterol after damage. Electron micr...

LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nu...

Published in The EMBO journal

Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research revealed a role of mitochondria also in innate immune signaling; however, the mechanisms of how mitochondria affect signal transduction are poorly understood. Here, we show...