Inactive variants of death receptor p75 NTR reduce Alzheimer’s neuropathology by interfering with APP internalization
Published in The EMBO Journal
Inactive variants of death receptor p75 NTR reduce Alzheimer’s neuropathology by interfering with APP internalization
A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium
Published in The EMBO Journal
An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2.
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Published in The EMBO journal
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation
Published in The EMBO Journal
SARS‐CoV‐2 infection causes broad‐spectrum immunopathological disease, exacerbated by inflammatory co‐morbidities. A better understanding of mechanisms underpinning virus‐associated inflammation is required to develop effective therapeutics. Here we discover that SARS‐CoV‐2 replicates rapidly in lung epithelial cells despite triggering a robust inn...
Programmable C-to-U RNA editing using the human APOBEC3A deaminase.
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Published in The EMBO journal
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63‐branched ubiquitin chains
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Published in The EMBO Journal
Binding of K63‐linked ubiquitin chains via a tightly‐linked accessory domains allows two homologous human and yeast E2 enzymes to add further K48‐linked moieties and build branched conjugates.
Syncytia formation by SARS‐CoV‐2‐infected cells
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Published in The EMBO Journal
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
Published in The EMBO journal
Opposing activities of IFITM proteins in SARS‐CoV‐2 infection
...Published in The EMBO Journal
Interferon‐induced transmembrane proteins (IFITMs) restrict infections by many viruses, but a subset of IFITMs enhance infections by specific coronaviruses through currently unknown mechanisms. We show that SARS‐CoV‐2 Spike‐pseudotyped virus and genuine SARS‐CoV‐2 infections are generally restricted by human and mouse IFITM1, IFITM2, and IFITM3, us...
LRRK 2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK ‐mediated ubiquitination pathway
Published in The EMBO Journal
